Target Description

Type Detail
Target ID T89S77
Protein Name Platelet-derived growth factor subunit B
Uniprot ID P01127
Protein Name Alias PDGF subunit B;  PDGF-2;  Platelet-derived growth factor B chain;  Platelet-derived growth factor beta polypeptide;  Proto-oncogene c-Sis;  Becaplermin
Gene ID 5155
Gene Symbol PDGFB
Gene Alias PDGF2;  SIS
TTD T87350: Clinical Trial target
Pfam PF00341 ; PF04692
GO
1904707:positive regulation of vascular associated smooth muscle cell proliferation

0071506:cellular response to mycophenolic acid

0032091:negative regulation of protein binding

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0042803:protein homodimerization activity

0010628:positive regulation of gene expression

0061098:positive regulation of protein tyrosine kinase activity

0043410:positive regulation of MAPK cascade

0006468:protein phosphorylation

0000139:Golgi membrane

0005161:platelet-derived growth factor receptor binding

0042056:chemoattractant activity

0005576:extracellular region

0018105:peptidyl-serine phosphorylation

0048407:platelet-derived growth factor binding

0010544:negative regulation of platelet activation

0051897:positive regulation of protein kinase B signaling

0008284:positive regulation of cell population proliferation

0031954:positive regulation of protein autophosphorylation

0005737:cytoplasm

0032148:activation of protein kinase B activity

0051781:positive regulation of cell division

0005788:endoplasmic reticulum lumen

0002548:monocyte chemotaxis

0031093:platelet alpha granule lumen

0014911:positive regulation of smooth muscle cell migration

0045840:positive regulation of mitotic nuclear division

0002576:platelet degranulation

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0046982:protein heterodimerization activity

0009986:cell surface

0060326:cell chemotaxis

1905176:positive regulation of vascular associated smooth muscle cell dedifferentiation

0001892:embryonic placenta development

1905064:negative regulation of vascular associated smooth muscle cell differentiation

1902895:positive regulation of pri-miRNA transcription by RNA polymerase II

0070374:positive regulation of ERK1 and ERK2 cascade

2000573:positive regulation of DNA biosynthetic process

0048146:positive regulation of fibroblast proliferation

0072593:reactive oxygen species metabolic process

0070851:growth factor receptor binding

0043406:positive regulation of MAP kinase activity

0048661:positive regulation of smooth muscle cell proliferation

0016176:superoxide-generating NADPH oxidase activator activity

0043536:positive regulation of blood vessel endothelial cell migration

0045892:negative regulation of transcription, DNA-templated

0072255:metanephric glomerular mesangial cell development

0008083:growth factor activity

0042802:identical protein binding

0010629:negative regulation of gene expression

0048008:platelet-derived growth factor receptor signaling pathway

0030198:extracellular matrix organization

0070528:protein kinase C signaling

1900127:positive regulation of hyaluronan biosynthetic process

2000379:positive regulation of reactive oxygen species metabolic process

0090280:positive regulation of calcium ion import

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0071363:cellular response to growth factor stimulus

0016323:basolateral plasma membrane

0032147:activation of protein kinase activity

0072126:positive regulation of glomerular mesangial cell proliferation

0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

0018108:peptidyl-tyrosine phosphorylation

0005796:Golgi lumen

1904754:positive regulation of vascular associated smooth muscle cell migration

2000591:positive regulation of metanephric mesenchymal cell migration

0009611:response to wounding

0062023:collagen-containing extracellular matrix

0050921:positive regulation of chemotaxis

0005615:extracellular space

0045893:positive regulation of transcription, DNA-templated

0003104:positive regulation of glomerular filtration

0007507:heart development

0001938:positive regulation of endothelial cell proliferation

0035655:interleukin-18-mediated signaling pathway

0000165:MAPK cascade

0030335:positive regulation of cell migration

0038001:paracrine signaling

0045737:positive regulation of cyclin-dependent protein serine/threonine kinase activity

0005518:collagen binding

1902894:negative regulation of pri-miRNA transcription by RNA polymerase II

0010512:negative regulation of phosphatidylinositol biosynthetic process

0010811:positive regulation of cell-substrate adhesion

PDB 3MJG ; 1PDG ; 4HQU ; 4HQX ; 6T9E ; 4QCI
Drugbank DB06325
KEGG hsa:5155

Related Compounds  (Total: 1)

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C0047
Name: Epigalocatechin Gallate


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