HIT-result

Type	Detail
Target ID	T53RK9
Protein Name	T-cell surface glycoprotein CD4
Uniprot ID	P01730
Protein Name Alias	T-cell surface antigen T4/Leu-3; CD antigen CD4
Gene ID	920
Gene Symbol	CD4
Gene Alias	NA
TTD	T10191: Successful target
Pfam	PF12104 ; PF05790 ; PF00047 ; PF09191
GO	0042012:interleukin-16 receptor activity 0042289:MHC class II protein binding 0030217:T cell differentiation 0043410:positive regulation of MAPK cascade 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0023026:MHC class II protein complex binding 0032507:maintenance of protein location in cell 0042011:interleukin-16 binding 0005789:endoplasmic reticulum membrane 0044409:entry into host 0030669:clathrin-coated endocytic vesicle membrane 1990782:protein tyrosine kinase binding 0033280:response to vitamin D 0007167:enzyme linked receptor protein signaling pathway 0038023:signaling receptor activity 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0061024:membrane organization 0042102:positive regulation of T cell proliferation 0005201:extracellular matrix structural constituent 0050850:positive regulation of calcium-mediated signaling 0006948:induction by virus of host cell-cell fusion 0001934:positive regulation of protein phosphorylation 0001618:virus receptor activity 0045058:T cell selection 0042802:identical protein binding 0009897:external side of plasma membrane 0030225:macrophage differentiation 0032743:positive regulation of interleukin-2 production 0007166:cell surface receptor signaling pathway 0010524:positive regulation of calcium ion transport into cytosol 0002250:adaptive immune response 0042110:T cell activation 0005886:plasma membrane 0033674:positive regulation of kinase activity 0046598:positive regulation of viral entry into host cell 0019899:enzyme binding 0051924:regulation of calcium ion transport 0005887:integral component of plasma membrane 0035723:interleukin-15-mediated signaling pathway 0045893:positive regulation of transcription, DNA-templated 0032355:response to estradiol 0008270:zinc ion binding 0042101:T cell receptor complex 0050829:defense response to Gram-negative bacterium 0042803:protein homodimerization activity 0019064:fusion of virus membrane with host plasma membrane 0035397:helper T cell enhancement of adaptive immune response 0019901:protein kinase binding 0097011:cellular response to granulocyte macrophage colony-stimulating factor stimulus 0019221:cytokine-mediated signaling pathway 0006955:immune response 0045121:membrane raft 0004888:transmembrane signaling receptor activity 0015026:coreceptor activity 0019865:immunoglobulin binding 0070374:positive regulation of ERK1 and ERK2 cascade 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0005769:early endosome 0005788:endoplasmic reticulum lumen 0050690:regulation of defense response to virus by virus 0007155:cell adhesion 0050852:T cell receptor signaling pathway 0007165:signal transduction 0045860:positive regulation of protein kinase activity 0050863:regulation of T cell activation 0045657:positive regulation of monocyte differentiation
PDB	2NXZ ; 6OPP ; 6L1Y ; 1WIO ; 6QH6 ; 4R4H ; 1CDJ ; 1CDH ; 5VN3 ; 5A8H ; 1WIQ ; 1OPW ; 4P9H ; 3JCC ; 1CDI ; 2NY5 ; 1CDU ; 2NXY ; 2NY6 ; 4Q6I ; 4R2G ; 6U0N ; 1OPT ; 6OPN ; 6OPO ; 3CD4 ; 3LQA ; 1RZJ ; 3S4S ; 4H8W ; 1JL4 ; 3JCB ; 5U1F ; 3T0E ; 3B71 ; 3J70 ; 5A7X ; 6X5C ; 3O2D ; 2JKT ; 6MEO ; 6U0L ; 4RQS ; 5CAY ; 2JKR ; 1Q68 ; 3S5L ; 1RZK ; 5THR ; 2NY0 ; 1GC1 ; 2NY1 ; 2NY4 ; 3JWO ; 2NY3 ; 1WBR ; 2QAD ; 6QH7 ; 6OPQ ; 1G9N ; 1G9M ; 3JWD ; 1OPN ; 1WIP ; 6X5B ; 6MET ; 2KLU ; 4JM2 ; 6CM3 ; 6EDU ; 2NY2 ; 1CDY ; 2B4C
Drugbank	DB12698 ; DB06241 ; DB00098
KEGG	hsa:920

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Name: Epigalocatechin Gallate

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Name: Catechin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0858	Zong Lv Pi	棕榈皮	Fortune windmillpalm	Trachycarpus fortunei
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0043	Jie Zi	芥子	India mustard seed	Brassica juncea
H1036	Fen Dan Pi	粉丹皮	Tree peony bark	Paeonia suffruticosa
H0857	Zong Ban Tan	棕板炭	NA	Trachycarpus fortunei
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0365	Rou Dou Kou	肉豆蔻	Common nutmeg	Myristica fragrans
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida
H0860	Zong Lv Zi	棕榈子	NA	Trachycarpus fortunei
H0764	Yu Xing Cao	鱼腥草	Heartleaf houttuynia	Houttuynia cordata
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0181	Luo Bu Ma	罗布麻	Dogbane	Apocynum venetum
H0601	Wu Mei	乌梅	Japanese apricot	Prunus mume
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H1053	Fu Ling	茯苓	Indian bread	Wolfiporia cocos
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0189	Lv Cha	绿茶	Green tea	Folium camelliae sinensis
H0773	Chi Fu Ling	赤茯苓	light red indian bread	Wolfiporia cocos
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0825	Zhu Fu Shen	朱茯神	Indian bread with pine	Poria cocos
H1099	Gou Teng	钩藤	Sharpleaf gambirplant	Uncaria rhynchophylla
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H1137	Gui Yuan	桂圆	NA	Dimocarpus longan
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H0485	Shui Hong Hua	水红花	Fructus polygoni orientalis	Polygonum orientale
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H0519	Suo Yang	锁阳	Songaria cynomorium	Cynomorium songaricum
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0777	Zao Jia	皂荚	Chinese honeylocust	Gleditsia sinensis
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0486	Shui Hong Hua Ye	水红花叶	Fructus polygoni orientalis	Polygonum orientale
H0068	Jin Ying Zi Rou	金樱子肉	Cherokee rose seed	Rosa laevigata
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H0779	Zao Jiao Zhen	皂角针	Chinese honeylocust spine	Gleditsia sinensis
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0721	Yang Mei Gen	杨梅根	Myrica rubra sieb. et zucc	Myrica rubra
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida
H0856	Zong Ban	棕板	NA	Trachycarpus fortunei
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H1217	Bai Mei Hua	白梅花	Japanese apricot flower	Prunus mume
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0698	Ya Zao	牙皂	Chinese honeylocust abnormal fruit	Gleditsia sinensis
H0067	Jin Ying Zi	金樱子	Cherokee rose seed	Rosa laevigata
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0939	Da Xue Teng	大血藤	Sargentgloryvine	Sargentodoxa cuneata
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0602	Wu Mei Rou	乌梅肉	Ebony	Prunus mume
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0069	Jin Ying Zi Ti Qu Ye	金樱子提取液	Cherokee rose seed	Rosa laevigata
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0007	Huo Xue Teng	活血藤	NA	Sargentodoxa cuneata
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1061	Bai He	百合	Lily	Lilium brownii
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H0464	Shi Liu Zi	石榴子	NA	Punica granatum

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 97)