Compound Description
| ID: C0114 | Common name: (-)-Epicatechin |
| IUPAC: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol | CAS: NA |
| Chembl ID: CHEMBL583912 | Pubchem ID: CID:72276 |
| Formula: C15H14O6 | TCM-ID: TCMC13 |
| Smiles: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 11)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T03CZ8 | Catechol O-methyltransferase | COMT |
P21964 |
A | 1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
A | 2 Reference(s) |
| T28PHS | Angiotensin-converting enzyme | ACE |
P12821 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
B | 1 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
B | 2 Reference(s) |
| T80U0C | Glutathione synthetase | GSS |
P48637 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
C | 1 Reference(s) |
| T84VZG | Ryanodine receptor 1 | RYR1 |
P21817 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 104)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0104 | Bai Zhu | 白术 | Largehead atractylodes | Atractylodes macrocephala |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0342 | Qing Hao | 青蒿 | sweet wormwood | Artemisia carvifolia |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0362 | Rong Shu Xu | 榕树须 | Banyan | Ficus microcarpa |
| H1127 | Guang Shan Zha | 广山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H1140 | Guo Gang Long | 过岗龙 | NA | Entada phaseoloides |
| H0181 | Luo Bu Ma | 罗布麻 | Dogbane | Apocynum venetum |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H1068 | Bai He Liu Jin Gao | 百合流浸膏 | Lily | Lilium brownii |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H0422 | Shan Zha Tan | 山楂炭 | Chinese hawthorn | Crataegus pinnatifida |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0020 | Ji Yan Cao | 鸡眼草 | Striate kummerowia | Kummerowia striata |
| H0229 | Mao Da Ding Cao | 毛大丁草 | Pilose gerbera | Gerbera piloselloides |
| H1099 | Gou Teng | 钩藤 | Sharpleaf gambirplant | Uncaria rhynchophylla |
| H0868 | Chuan Du Huo | 川独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0615 | Wu Zhi Mao Tao | 五指毛桃 | five-finger fig root | Ficus simplicissima |
| H0565 | Tu Bie Chong | 土鳖虫 | Cockroach | Eupolyphaga sinensis |
| H0351 | Quan Shen | 拳参 | Bistort | Polygonum bistorta |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0420 | Shan Zha Chou Gao | 山楂稠膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0519 | Suo Yang | 锁阳 | Songaria cynomorium | Cynomorium songaricum |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0284 | Nan She Teng | 南蛇藤 | Oriental bittersweet | Celastrus orbiculatus |
| H0343 | Qing Hao Zi | 青蒿子 | sweet wormwood | Artemisia carvifolia |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0989 | Ding Kui Cao | 丁葵草 | Herb of twinleaf zornia | Kummerowia striata |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0777 | Zao Jia | 皂荚 | Chinese honeylocust | Gleditsia sinensis |
| H0793 | Zhao Shan Bai | 照山白 | Manchurian rhododendron | Rhododendron micranthum |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0220 | Man Shan Hong You | 满山红油 | Daurian rhododendron oil | Oleum rhododendri daurici |
| H0361 | Ren Zi Cao | 人字草 | Herb of twinleaf zornia | Kummerowia striata |
| H0068 | Jin Ying Zi Rou | 金樱子肉 | Cherokee rose seed | Rosa laevigata |
| H0925 | Da Fu Zi | 大腹子 | Areca palm | Areca catechu |
| H1214 | Hua Jiao | 花椒 | Bunge pricklyash | Zanthoxylum bungeanum |
| H0779 | Zao Jiao Zhen | 皂角针 | Chinese honeylocust spine | Gleditsia sinensis |
| H0363 | Rong Shu Ye | 榕树叶 | Banyan | Ficus microcarpa |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0408 | Bing Lang | 槟榔 | Betenutpalm | Areca catechu |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0532 | Teng Huang | 藤黄 | Gamboge tree resin | Garcinia morella |
| H0733 | Ye Shan Zha | 野山楂 | nippon bawthorn | Crataegus pinnatifida |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H0534 | Teng Li Gen | 藤梨根 | NA | Actinidia arguta |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H1102 | Gu Sui Bu | 骨碎补 | Fortune’s drynaria rhizome | Drynaria fortunei |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H1212 | Hu Ye Gan Jin Gao | 槲叶干浸膏 | NA | Quercus dentata |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1141 | Guo Gang Long Jin Gao | 过岗龙浸膏 | NA | Entada phaseoloides |
| H0698 | Ya Zao | 牙皂 | Chinese honeylocust abnormal fruit | Gleditsia sinensis |
| H1211 | Bai Mei | 白眉 | pilose gerbera herb | Gerbera piloselloides |
| H0067 | Jin Ying Zi | 金樱子 | Cherokee rose seed | Rosa laevigata |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H0421 | Shan Zha Qing Gao | 山楂清膏 | Chinese hawthorn | Crataegus pinnatifida |
| H1009 | Du Huo | 独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H1029 | Fang Er Cha | 方儿茶 | khair in hindi | Senegalia catechu |
| H0939 | Da Xue Teng | 大血藤 | Sargentgloryvine | Sargentodoxa cuneata |
| H0056 | Jin Qiao Mai | 金荞麦 | Wild buckwheat rhizome | Rhizoma fagopyri cymosi |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H0069 | Jin Ying Zi Ti Qu Ye | 金樱子提取液 | Cherokee rose seed | Rosa laevigata |
| H0007 | Huo Xue Teng | 活血藤 | NA | Sargentodoxa cuneata |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H1061 | Bai He | 百合 | Lily | Lilium brownii |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0120 | Ban Bian Qi | 半边旗 | pinnated brake herb | Pteris semipinnata |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0457 | Shi Er | 石耳 | Rock-Ears | Umbilicaria esculenta |
Ckey description of the interaction between compound and target