HIT-result

Type	Detail
Target ID	T85C8T
Protein Name	Serine/threonine-protein kinase PAK 4
Uniprot ID	O96013
Protein Name Alias	EC 2.7.11.1; p21-activated kinase 4; PAK-4
Gene ID	10298
Gene Symbol	PAK4
Gene Alias	KIAA1142
TTD	T98293: Clinical Trial target
Pfam	PF00786 ; PF00069
GO	0005524:ATP binding 0004672:protein kinase activity 0106310:protein serine kinase activity 0005912:adherens junction 0007049:cell cycle 0045766:positive regulation of angiogenesis 0005925:focal adhesion 0032147:activation of protein kinase activity 0004674:protein serine/threonine kinase activity 0031098:stress-activated protein kinase signaling cascade 0007010:cytoskeleton organization 0016477:cell migration 0001558:regulation of cell growth 0060996:dendritic spine development 0098641:cadherin binding involved in cell-cell adhesion 0106311:protein threonine kinase activity 0071407:cellular response to organic cyclic compound 0006915:apoptotic process 0005794:Golgi apparatus 2000352:negative regulation of endothelial cell apoptotic process 0005737:cytoplasm 0007165:signal transduction
PDB	2J0I ; 2Q0N ; 2CDZ ; 4APP ; 4FIJ ; 4FIE ; 5UPK ; 5XVA ; 4JDH ; 4FII ; 4O0Y ; 6WLX ; 6WLY ; 4FIF ; 4XBU ; 4JDJ ; 5XVG ; 4FIG ; 4JDI ; 5UPL ; 2OV2 ; 5VEE ; 5BMS ; 4O0X ; 5VEF ; 4NJD ; 4XBR ; 4FIH ; 4L67 ; 2BVA ; 4JDK ; 5VED ; 5XVF ; 2X4Z ; 5I0B ; 4O0V ; 5ZJW
Drugbank	DB12010
KEGG	hsa:10298

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis

Target Description