HIT-result

Type	Detail
Target ID	T49IR9
Protein Name	D(4) dopamine receptor
Uniprot ID	P21917
Protein Name Alias	D(2C) dopamine receptor; Dopamine D4 receptor
Gene ID	1815
Gene Symbol	DRD4
Gene Alias	NA
TTD	T24983: Successful target
Pfam	PF00001
GO	0035240:dopamine binding 0042802:identical protein binding 0042596:fear response 0051586:positive regulation of dopamine uptake involved in synaptic transmission 0032417:positive regulation of sodium:proton antiporter activity 0007268:chemical synaptic transmission 0035176:social behavior 0098794:postsynapse 0050709:negative regulation of protein secretion 0042752:regulation of circadian rhythm 0098978:glutamatergic synapse 0048148:behavioral response to cocaine 0001975:response to amphetamine 0004993:G protein-coupled serotonin receptor activity 0000187:activation of MAPK activity 0050482:arachidonic acid secretion 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0051379:epinephrine binding 0001662:behavioral fear response 0005887:integral component of plasma membrane 0099149:regulation of postsynaptic neurotransmitter receptor internalization 0006874:cellular calcium ion homeostasis 0001591:dopamine neurotransmitter receptor activity, coupled via Gi/Go 0005886:plasma membrane 0030425:dendrite 0017124:SH3 domain binding 0034776:response to histamine 0060080:inhibitory postsynaptic potential 0030594:neurotransmitter receptor activity 0048511:rhythmic process 0016020:membrane 0015459:potassium channel regulator activity 0051380:norepinephrine binding 0007212:dopamine receptor signaling pathway 0042417:dopamine metabolic process 0048149:behavioral response to ethanol 0007186:G protein-coupled receptor signaling pathway 0033674:positive regulation of kinase activity 0046872:metal ion binding 0008344:adult locomotory behavior 0042053:regulation of dopamine metabolic process 0004952:dopamine neurotransmitter receptor activity 1901386:negative regulation of voltage-gated calcium channel activity 0007195:adenylate cyclase-inhibiting dopamine receptor signaling pathway
PDB	5WIU ; 5WIV
Drugbank	DB13345 ; DB00246 ; DB01049 ; DB09286 ; DB00334 ; DB00268 ; DB00248 ; DB04946 ; DB01186 ; DB01200 ; DB00490 ; DB06477 ; DB14185 ; DB00543 ; DB00714 ; DB11275 ; DB01238 ; DB01224 ; DB00589 ; DB01403 ; DB04908 ; DB12061 ; DB08922 ; DB00363 ; DB01267 ; DB00477 ; DB00413 ; DB05271 ; DB06216 ; DB01235 ; DB00988 ; DB00408 ; DB00409
KEGG	hsa:1815

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Name: Dopamine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens