Target Description

Type Detail
Target ID T35OPL
Protein Name Sonic hedgehog protein
Uniprot ID Q15465
Protein Name Alias SHH;  HHG-1;  Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;  ShhNC
Gene ID 6469
Gene Symbol SHH
Gene Alias NA
TTD T12075: Research target
Pfam PF01079 ; PF01085
GO
0021904:dorsal/ventral neural tube patterning

0072136:metanephric mesenchymal cell proliferation involved in metanephros development

0046639:negative regulation of alpha-beta T cell differentiation

0034244:negative regulation of transcription elongation from RNA polymerase II promoter

0001658:branching involved in ureteric bud morphogenesis

0042127:regulation of cell population proliferation

0021930:cerebellar granule cell precursor proliferation

0010468:regulation of gene expression

0007418:ventral midline development

0048538:thymus development

0008284:positive regulation of cell population proliferation

0051781:positive regulation of cell division

0061189:positive regulation of sclerotome development

0002320:lymphoid progenitor cell differentiation

0060840:artery development

0021794:thalamus development

0030010:establishment of cell polarity

0060174:limb bud formation

0045060:negative thymic T cell selection

0007596:blood coagulation

0060463:lung lobe morphogenesis

0035116:embryonic hindlimb morphogenesis

0033092:positive regulation of immature T cell proliferation in thymus

0035115:embryonic forelimb morphogenesis

0007267:cell-cell signaling

0048864:stem cell development

0030878:thyroid gland development

2000357:negative regulation of kidney smooth muscle cell differentiation

0048859:formation of anatomical boundary

0005576:extracellular region

0045109:intermediate filament organization

0001755:neural crest cell migration

0008270:zinc ion binding

0006897:endocytosis

2000063:positive regulation of ureter smooth muscle cell differentiation

0045944:positive regulation of transcription by RNA polymerase II

0043066:negative regulation of apoptotic process

0030850:prostate gland development

0060516:primary prostatic bud elongation

0060447:bud outgrowth involved in lung branching

0007389:pattern specification process

0062023:collagen-containing extracellular matrix

0072205:metanephric collecting duct development

0005829:cytosol

0030901:midbrain development

2000062:negative regulation of ureter smooth muscle cell differentiation

0030162:regulation of proteolysis

0048709:oligodendrocyte differentiation

0060916:mesenchymal cell proliferation involved in lung development

0003140:determination of left/right asymmetry in lateral mesoderm

0060664:epithelial cell proliferation involved in salivary gland morphogenesis

0045880:positive regulation of smoothened signaling pathway

0016539:intein-mediated protein splicing

0060459:left lung development

0005509:calcium ion binding

0042307:positive regulation of protein import into nucleus

0005615:extracellular space

0007224:smoothened signaling pathway

2000358:positive regulation of kidney smooth muscle cell differentiation

0032435:negative regulation of proteasomal ubiquitin-dependent protein catabolic process

0046638:positive regulation of alpha-beta T cell differentiation

0045121:membrane raft

0060685:regulation of prostatic bud formation

0009949:polarity specification of anterior/posterior axis

0021978:telencephalon regionalization

0030900:forebrain development

0048645:animal organ formation

0045445:myoblast differentiation

0048663:neuron fate commitment

0021938:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

0008233:peptidase activity

0007442:hindgut morphogenesis

0090090:negative regulation of canonical Wnt signaling pathway

0048839:inner ear development

0002076:osteoblast development

1904339:negative regulation of dopaminergic neuron differentiation

0014706:striated muscle tissue development

0014902:myotube differentiation

0034504:protein localization to nucleus

0001656:metanephros development

0030326:embryonic limb morphogenesis

0030336:negative regulation of cell migration

0060428:lung epithelium development

0048714:positive regulation of oligodendrocyte differentiation

0014858:positive regulation of skeletal muscle cell proliferation

0060523:prostate epithelial cord elongation

0030324:lung development

0048468:cell development

0048745:smooth muscle tissue development

0051155:positive regulation of striated muscle cell differentiation

0043237:laminin-1 binding

0007507:heart development

0048643:positive regulation of skeletal muscle tissue development

1900180:regulation of protein localization to nucleus

0043369:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

0009880:embryonic pattern specification

0060782:regulation of mesenchymal cell proliferation involved in prostate gland development

1900175:regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

0009986:cell surface

0060783:mesenchymal smoothened signaling pathway involved in prostate gland development

0045893:positive regulation of transcription, DNA-templated

1905327:tracheoesophageal septum formation

0000122:negative regulation of transcription by RNA polymerase II

0042130:negative regulation of T cell proliferation

0048557:embryonic digestive tract morphogenesis

0005539:glycosaminoglycan binding

0030539:male genitalia development

0016540:protein autoprocessing

0030902:hindbrain development

0021522:spinal cord motor neuron differentiation

0009953:dorsal/ventral pattern formation

0001708:cell fate specification

0061053:somite development

0031069:hair follicle morphogenesis

0005113:patched binding

0005788:endoplasmic reticulum lumen

0060445:branching involved in salivary gland morphogenesis

0008209:androgen metabolic process

0016015:morphogen activity

0045059:positive thymic T cell selection

0071285:cellular response to lithium ion

0001947:heart looping

0048706:embryonic skeletal system development

0043010:camera-type eye development

0071542:dopaminergic neuron differentiation

0042733:embryonic digit morphogenesis

0042481:regulation of odontogenesis

0060021:roof of mouth development

0033089:positive regulation of T cell differentiation in thymus

0045596:negative regulation of cell differentiation

0031016:pancreas development

0033077:T cell differentiation in thymus

0060070:canonical Wnt signaling pathway

0060439:trachea morphogenesis

2000729:positive regulation of mesenchymal cell proliferation involved in ureter development

0005886:plasma membrane

0001570:vasculogenesis

0097190:apoptotic signaling pathway

0021513:spinal cord dorsal/ventral patterning

0048617:embryonic foregut morphogenesis

0060458:right lung development

0060662:salivary gland cavitation

0048754:branching morphogenesis of an epithelial tube

0001569:branching involved in blood vessel morphogenesis

0060738:epithelial-mesenchymal signaling involved in prostate gland development

0042475:odontogenesis of dentin-containing tooth

0007398:ectoderm development

0007417:central nervous system development

0060769:positive regulation of epithelial cell proliferation involved in prostate gland development

0060484:lung-associated mesenchyme development

0007405:neuroblast proliferation

0014003:oligodendrocyte development

0030177:positive regulation of Wnt signaling pathway

0060020:Bergmann glial cell differentiation

0090370:negative regulation of cholesterol efflux

0007228:positive regulation of hh target transcription factor activity

0002052:positive regulation of neuroblast proliferation

0007411:axon guidance

2001054:negative regulation of mesenchymal cell apoptotic process

PDB 6RMG ; 6N7H ; 6N7K ; 3MXW ; 6N7G ; 6PJV ; 6E1H ; 6RVD ; 6OEV ; 6DMY ; 3HO5 ; 3M1N
Drugbank NA
KEGG hsa:6469

Related Compounds  (Total: 4)

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C0099
Name: Gedunin
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C0363
Name: Resveratrol
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C1234
Name: Cholesterol
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C1272
Name: Cyclopamine


Related Herbs  (Total: 51)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0476 Can E蚕蛾 SilkwormBombyx mori
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0357 Ren Shen人参 GinsengPanax ginseng
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora