Target Description

Type Detail
Target ID T58CAO
Protein Name Alpha-synuclein
Uniprot ID P37840
Protein Name Alias Non-A beta component of AD amyloid;  Non-A4 component of amyloid precursor;  NACP
Gene ID 6622
Gene Symbol SNCA
Gene Alias NACP;  PARK1
TTD T03644: Clinical Trial target
Pfam PF01387
GO
0016082:synaptic vesicle priming

0005543:phospholipid binding

0051621:regulation of norepinephrine uptake

1990000:amyloid fibril formation

0032410:negative regulation of transporter activity

0050729:positive regulation of inflammatory response

0016020:membrane

0032991:protein-containing complex

0014059:regulation of dopamine secretion

1901215:negative regulation of neuron death

0045807:positive regulation of endocytosis

0043679:axon terminus

0019894:kinesin binding

0042393:histone binding

0035493:SNARE complex assembly

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0070495:negative regulation of thrombin-activated receptor signaling pathway

0031623:receptor internalization

0051262:protein tetramerization

0005764:lysosome

0071872:cellular response to epinephrine stimulus

0010642:negative regulation of platelet-derived growth factor receptor signaling pathway

0034341:response to interferon-gamma

0005576:extracellular region

0030426:growth cone

0006469:negative regulation of protein kinase activity

1903136:cuprous ion binding

0034599:cellular response to oxidative stress

0005737:cytoplasm

1901214:regulation of neuron death

0051583:dopamine uptake involved in synaptic transmission

0035543:positive regulation of SNARE complex assembly

0005829:cytosol

0042416:dopamine biosynthetic process

0045921:positive regulation of exocytosis

0048488:synaptic vesicle endocytosis

0035067:negative regulation of histone acetylation

0010040:response to iron(II) ion

0051219:phosphoprotein binding

0048156:tau protein binding

0030544:Hsp70 protein binding

0043014:alpha-tubulin binding

0043065:positive regulation of apoptotic process

0016234:inclusion body

0016491:oxidoreductase activity

0005886:plasma membrane

0070840:dynein complex binding

0005938:cell cortex

0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0010517:regulation of phospholipase activity

1901216:positive regulation of neuron death

0016079:synaptic vesicle exocytosis

1905606:regulation of presynapse assembly

0007268:chemical synaptic transmission

0048471:perinuclear region of cytoplasm

0031648:protein destabilization

1904715:negative regulation of chaperone-mediated autophagy

0022898:regulation of transmembrane transporter activity

0043066:negative regulation of apoptotic process

0070555:response to interleukin-1

0042802:identical protein binding

0050808:synapse organization

0015629:actin cytoskeleton

0031115:negative regulation of microtubule polymerization

0032769:negative regulation of monooxygenase activity

0000122:negative regulation of transcription by RNA polymerase II

0001774:microglial cell activation

0033138:positive regulation of peptidyl-serine phosphorylation

0099512:supramolecular fiber

0071902:positive regulation of protein serine/threonine kinase activity

0005507:copper ion binding

0045920:negative regulation of exocytosis

0001921:positive regulation of receptor recycling

1902957:negative regulation of mitochondrial electron transport, NADH to ubiquinone

0030424:axon

1903421:regulation of synaptic vesicle recycling

1903285:positive regulation of hydrogen peroxide catabolic process

0097435:supramolecular fiber organization

0060732:positive regulation of inositol phosphate biosynthetic process

0051612:negative regulation of serotonin uptake

0003779:actin binding

0051622:negative regulation of norepinephrine uptake

0005509:calcium ion binding

0005739:mitochondrion

0005634:nucleus

0008198:ferrous iron binding

0071280:cellular response to copper ion

0000149:SNARE binding

1903426:regulation of reactive oxygen species biosynthetic process

0008270:zinc ion binding

0032496:response to lipopolysaccharide

0000976:transcription regulatory region sequence-specific DNA binding

0005615:extracellular space

1903284:positive regulation of glutathione peroxidase activity

0051585:negative regulation of dopamine uptake involved in synaptic transmission

0051281:positive regulation of release of sequestered calcium ion into cytosol

0004860:protein kinase inhibitor activity

0032026:response to magnesium ion

0043025:neuronal cell body

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0000287:magnesium ion binding

PDB 6OSM ; 6CU8 ; 2N0A ; 6XYP ; 6OSJ ; 4RIK ; 6RT0 ; 6CU7 ; 6PEO ; 3Q29 ; 6FLT ; 6RTB ; 4RIL ; 6SSX ; 6XYQ ; 5CRW ; 6SST ; 6LRQ ; 4R0W ; 2M55 ; 6CT7 ; 2X6M ; 3Q27 ; 6PES ; 6L1T ; 1XQ8 ; 2KKW ; 6OSL ; 6UFR ; 6I42 ; 4BXL ; 6XYO ; 6H6B ; 3Q26 ; 4R0U ; 6L4S ; 6L1U ; 3Q28 ; 4ZNN ; 6A6B ; 3Q25 ; 2JN5
Drugbank DB02709 ; DB09130
KEGG hsa:6622

Related Compounds  (Total: 10)

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C0034
Name: Dopamine
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C0213
Name: Metformin
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C0282
Name: Paeoniflorin
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C0375
Name: Rotenone
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C0540
Name: Cis-Asarone


Related Herbs  (Total: 59)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0683 Xiu Xian Ju绣线菊 Japanese spiraeaSpiraea japonica
H0416 Shan Shen山参 NAPanax ginseng
H0864 Cu Jiang Cao酢浆草 Creeping oxalisOxalis corniculata
H1165 He Shi鹤虱 Common carpesium fruitFructus carpesii
H0669 Xie Bai薤白 Longstamen onionAllium macrostemon
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0769 Yuan Zhi远志 Thinleaf milkwortPolygala tenuifolia
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H1004 Bai Cha白茶 White teaCamellia sinensis
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H1033 Fang Ji防己 Fourstamen stephaniaStephania tetrandra
H0699 Chang Pu菖蒲 rhizome of grassleaf sweetflag.Acorus calamus
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0938 Da Suan大蒜 GarlicAllium sativum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0483 Shui Chang Pu水菖蒲 CalamusAcorus calamus var. angustatus
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0257 Mo Gu蘑菇 MushroomAgaricus campestris
H0603 Wu Tong Ye Jin Gao梧桐叶浸膏 Parasol treesFirmiana simplex
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0357 Ren Shen人参 GinsengPanax ginseng
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0505 Cang Chang Pu藏菖蒲 Sweet flagAcorus calamus
H0771 Yuan Zhi Liu Jin Gao远志流浸膏 Thinleaf milkwortPolygala tenuifolia
H0770 Yuan Zhi Jin Gao远志浸膏 Thinleaf milkwortPolygala tenuifolia
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0341 Qing Feng Teng青风藤 OrientvineSinomenium acutum
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta