Compound Description

ID:   C0375 Common name:   Rotenone
IUPAC:  NA CAS:  CAS:83-79-4
Chembl ID:   CHEMBL429023 Pubchem ID:   CID:6758
Formula:  C23H22O6 TCM-ID:  TCMC2026
Smiles:  CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC
Alias:

Rotenone;

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2α,6aα,12aα)]-;

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aαH)-one, 1,2,12,12aα-tetrahydro-2α-isopropenyl-8,9-dimethoxy-;

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one;

(-)-Rotenone;

(-)-cis-Rotenone;

5'β-Rotenone;

CFT Legumine;

Cenol Garden Dust;

Chem Fish;

Chem-Mite;

Cube-Pulver;

Cuberol;

Curex flea duster;

Dactinol;

Deril;

Derrin;

Derris;

Derris (insecticide);

Dri-kil;

Fish Tox;

Fish Tox 5;

Green cross warble powder;

Liquid Derris;

NSC 26258;

NSC 8505;

Nicouline;

Noxfire;

Noxfish;

Paraderil;

Prenfish Toxicant;

Prentox Prenfish;

Prentox Prenfish Toxicant;

Ronone;

Rotacide;

Rotacide EC;

Rotena;

Rotenon;

Rotenox;

Rotocide;

Sinid;

TIFA Chem Fish;

Tox-R;

Tubatoxin;

YuTengTong
Structure:

Related Targets  (Total: 24)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
A 2 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
A 1 Reference(s)
T00BH5 NADH-ubiquinone oxidoreductase chain 2MT-ND2 P03891
A 1 Reference(s)
T23O0E MulticilinMCIDAS D6RGH6
A 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
B 1 Reference(s)
T00HDE Parkinson disease protein 7PARK7 Q99497
B 1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
B 1 Reference(s)
T16A2X CatalaseCAT P04040
B 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
B 2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 2 Reference(s)
T23Z2G Glyceraldehyde-3-phosphate dehydrogenaseGAPDH P04406
B 1 Reference(s)
T58CAO Alpha-synucleinSNCA P37840
C 1 Reference(s)
T37DRC Short transient receptor potential channel 3TRPC3 Q13507
C 1 Reference(s)
T18RS6 Glutamate receptor ionotropic, NMDA 2BGRIN2B Q13224
C 1 Reference(s)
T81LOK Nuclear receptor subfamily 4 group A member 2NR4A2 P43354
C 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
C 1 Reference(s)
T09BRP NAPKB_RS07820 NA
C 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
C 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
C 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
C 1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 4)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0683 Xiu Xian Ju绣线菊 Japanese spiraeaSpiraea japonica
H0257 Mo Gu蘑菇 MushroomAgaricus campestris
H0864 Cu Jiang Cao酢浆草 Creeping oxalisOxalis corniculata
H0669 Xie Bai薤白 Longstamen onionAllium macrostemon