HIT-result

Type	Detail
Target ID	T81LOK
Protein Name	Nuclear receptor subfamily 4 group A member 2
Uniprot ID	P43354
Protein Name Alias	Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
Gene ID	4929
Gene Symbol	NR4A2
Gene Alias	NOT; NURR1; TINUR
TTD	T67163: Research target
Pfam	PF00105 ; PF00104
GO	0003677:DNA binding 0005634:nucleus 0006351:transcription, DNA-templated 0021952:central nervous system projection neuron axonogenesis 0035259:glucocorticoid receptor binding 0043524:negative regulation of neuron apoptotic process 0051866:general adaptation syndrome 0009791:post-embryonic development 0001764:neuron migration 0034599:cellular response to oxidative stress 0042551:neuron maturation 0001975:response to amphetamine 0001666:response to hypoxia 0042416:dopamine biosynthetic process 0071542:dopaminergic neuron differentiation 0045444:fat cell differentiation 0005737:cytoplasm 0021953:central nervous system neuron differentiation 0031668:cellular response to extracellular stimulus 0043576:regulation of respiratory gaseous exchange 0071376:cellular response to corticotropin-releasing hormone stimulus 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0060070:canonical Wnt signaling pathway 2001234:negative regulation of apoptotic signaling pathway 0000785:chromatin 0005667:transcription regulator complex 0032991:protein-containing complex 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0000122:negative regulation of transcription by RNA polymerase II 0008270:zinc ion binding 0043085:positive regulation of catalytic activity 0007165:signal transduction 0006357:regulation of transcription by RNA polymerase II 0046982:protein heterodimerization activity 0046965:retinoid X receptor binding 0006367:transcription initiation from RNA polymerase II promoter 1904948:midbrain dopaminergic neuron differentiation 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 1990837:sequence-specific double-stranded DNA binding 0008344:adult locomotory behavior 0016607:nuclear speck 0042053:regulation of dopamine metabolic process 0045944:positive regulation of transcription by RNA polymerase II 0004879:nuclear receptor activity 0021986:habenula development 0008013:beta-catenin binding
PDB	6L6L ; 5Y41 ; 6L6Q ; 5YD6 ; 1OVL ; 6DDA
Drugbank	NA
KEGG	hsa:4929

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Name: Dopa

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Name: Dopamine

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Name: Rotenone

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Name: Dopa

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