HIT-result

Type	Detail
Target ID	T00HDE
Protein Name	Parkinson disease protein 7
Uniprot ID	Q99497
Protein Name Alias	Maillard deglycase; Oncogene DJ1; Parkinsonism-associated deglycase; Protein DJ-1; DJ-1; Protein/nucleic acid deglycase DJ-1; EC 3.1.2.-; EC 3.5.1.-; EC 3.5.1.124
Gene ID	11315
Gene Symbol	PARK7
Gene Alias	NA
TTD	NA
Pfam	PF01965
GO	0016605:PML body 0036478:L-dopa decarboxylase activator activity 1903197:positive regulation of L-dopa biosynthetic process 0051920:peroxiredoxin activity 1903427:negative regulation of reactive oxygen species biosynthetic process 0032091:negative regulation of protein binding 0002866:positive regulation of acute inflammatory response to antigenic stimulus 0045296:cadherin binding 0016570:histone modification 1901215:negative regulation of neuron death 0008344:adult locomotory behavior 0061727:methylglyoxal catabolic process to lactate 0042803:protein homodimerization activity 0010628:positive regulation of gene expression 0070062:extracellular exosome 0044877:protein-containing complex binding 0106045:guanine deglycation, methylglyoxal removal 0010273:detoxification of copper ion 0051881:regulation of mitochondrial membrane potential 0008134:transcription factor binding 1903181:positive regulation of dopamine biosynthetic process 0046826:negative regulation of protein export from nucleus 0140041:cellular detoxification of methylglyoxal 2000825:positive regulation of androgen receptor activity 0110095:cellular detoxification of aldehyde 0036471:cellular response to glyoxal 1903599:positive regulation of autophagy of mitochondrion 0044388:small protein activating enzyme binding 0051897:positive regulation of protein kinase B signaling 0046295:glycolate biosynthetic process 0006469:negative regulation of protein kinase activity 1903136:cuprous ion binding 2000277:positive regulation of oxidative phosphorylation uncoupler activity 0034599:cellular response to oxidative stress 1903202:negative regulation of oxidative stress-induced cell death 0005737:cytoplasm 0032148:activation of protein kinase B activity 0036528:peptidyl-lysine deglycation 0051583:dopamine uptake involved in synaptic transmission 0019826:oxygen sensor activity 0005829:cytosol 1901671:positive regulation of superoxide dismutase activity 0006281:DNA repair 0051444:negative regulation of ubiquitin-protein transferase activity 1903094:negative regulation of protein K48-linked deubiquitination 0033182:regulation of histone ubiquitination 0106046:guanine deglycation, glyoxal removal 1902177:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 0005654:nucleoplasm 1903428:positive regulation of reactive oxygen species biosynthetic process 0045944:positive regulation of transcription by RNA polymerase II 0006517:protein deglycosylation 1905259:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 0005783:endoplasmic reticulum 1902958:positive regulation of mitochondrial electron transport, NADH to ubiquinone 0009438:methylglyoxal metabolic process 1903208:negative regulation of hydrogen peroxide-induced neuron death 0035973:aggrephagy 0045340:mercury ion binding 0070301:cellular response to hydrogen peroxide 2000157:negative regulation of ubiquitin-specific protease activity 0005102:signaling receptor binding 0007265:Ras protein signal transduction 0106044:guanine deglycation 0005886:plasma membrane 0036470:tyrosine 3-monooxygenase activator activity 0036530:protein deglycation, methylglyoxal removal 0019955:cytokine binding 0050821:protein stabilization 0048471:perinuclear region of cytoplasm 1990381:ubiquitin-specific protease binding 0035065:regulation of histone acetylation 0019900:kinase binding 1900182:positive regulation of protein localization to nucleus 1903178:positive regulation of tyrosine 3-monooxygenase activity 0051091:positive regulation of DNA-binding transcription factor activity 0036529:protein deglycation, glyoxal removal 1903073:negative regulation of death-inducing signaling complex assembly 0070491:repressing transcription factor binding 0032757:positive regulation of interleukin-8 production 0005758:mitochondrial intermembrane space 0097110:scaffold protein binding 0050727:regulation of inflammatory response 0060548:negative regulation of cell death 1903135:cupric ion binding 0006954:inflammatory response 1902903:regulation of supramolecular fiber organization 0031397:negative regulation of protein ubiquitination 0043524:negative regulation of neuron apoptotic process 0043066:negative regulation of apoptotic process 0030073:insulin secretion 0042802:identical protein binding 0010629:negative regulation of gene expression 2001268:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1903200:positive regulation of L-dopa decarboxylase activity 1990422:glyoxalase (glycolic acid-forming) activity 0045121:membrane raft 0044297:cell body 1902236:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0033138:positive regulation of peptidyl-serine phosphorylation 0007338:single fertilization 0005507:copper ion binding 1901984:negative regulation of protein acetylation 0043523:regulation of neuron apoptotic process 0030424:axon 0050681:androgen receptor binding 1903206:negative regulation of hydrogen peroxide-induced cell death 1903168:positive regulation of pyrroline-5-carboxylate reductase activity 0008233:peptidase activity 0036527:peptidyl-arginine deglycation 0003729:mRNA binding 0005739:mitochondrion 0005634:nucleus 0033864:positive regulation of NAD(P)H oxidase activity 2001237:negative regulation of extrinsic apoptotic signaling pathway 0042593:glucose homeostasis 0016684:oxidoreductase activity, acting on peroxide as acceptor 0001933:negative regulation of protein phosphorylation 0042743:hydrogen peroxide metabolic process 0098793:presynapse 0060765:regulation of androgen receptor signaling pathway 0032435:negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2000679:positive regulation of transcription regulatory region DNA binding 0019899:enzyme binding 0050787:detoxification of mercury ion 0036531:glutathione deglycation 0019249:lactate biosynthetic process 0031334:positive regulation of protein-containing complex assembly 0070994:detection of oxidative stress 0005912:adherens junction 1903122:negative regulation of TRAIL-activated apoptotic signaling pathway 0033234:negative regulation of protein sumoylation 0016532:superoxide dismutase copper chaperone activity 0005759:mitochondrial matrix 0051899:membrane depolarization 1903377:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 0036526:peptidyl-cysteine deglycation 0003713:transcription coactivator activity 1903189:glyoxal metabolic process 1903384:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 0036524:protein deglycase activity 0044390:ubiquitin-like protein conjugating enzyme binding 0000785:chromatin 0007005:mitochondrion organization 0060081:membrane hyperpolarization
PDB	5SYA ; 4OGF ; 5SY9 ; 3F71 ; 4N0M ; 1Q2U ; 1PDW ; 2OR3 ; 6M8Z ; 1PE0 ; 4RKY ; 4MNT ; 3B36 ; 4BTE ; 1PDV ; 4P34 ; 3CZ9 ; 4MTC ; 6AFF ; 6AFE ; 6AFG ; 6E5Z ; 3EZG ; 6AFD ; 7C62 ; 2R1T ; 4OQ4 ; 6AFA ; 4P35 ; 6AFI ; 4ZGG ; 4S0Z ; 1SOA ; 2RK4 ; 3CY6 ; 6AF5 ; 4P2G ; 6AF9 ; 6AFH ; 2R1V ; 6AFB ; 4P36 ; 3B3A ; 2R1U ; 6AFC ; 1UCF ; 3BWE ; 4N12 ; 2RK3 ; 1P5F ; 6AFJ ; 3B38 ; 5SY6 ; 3SF8 ; 1J42 ; 2RK6 ; 5IP5 ; 4RKW ; 6AFL ; 3CYF ; 3CZA ; 6AF7
Drugbank	DB09130
KEGG	hsa:11315

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Name: Rotenone

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0257	Mo Gu	蘑菇	Mushroom	Agaricus campestris
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0864	Cu Jiang Cao	酢浆草	Creeping oxalis	Oxalis corniculata
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0683	Xiu Xian Ju	绣线菊	Japanese spiraea	Spiraea japonica
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0416	Shan Shen	山参	NA	Panax ginseng
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 29)