HIT-result

Target Description

Type	Detail
Target ID	T18RS6
Protein Name	Glutamate receptor ionotropic, NMDA 2B
Uniprot ID	Q13224
Protein Name Alias	GluN2B
Gene ID	2904
Gene Symbol	GRIN2B
Gene Alias	NMDAR2B
TTD	T76414: Successful target
Pfam	PF10613 ; PF01094 ; PF10565 ; PF00060
GO	0048167:regulation of synaptic plasticity 0007275:multicellular organism development 1902951:negative regulation of dendritic spine maintenance 0038023:signaling receptor activity 0005770:late endosome 0017146:NMDA selective glutamate receptor complex 0001540:amyloid-beta binding 0004972:NMDA glutamate receptor activity 0005789:endoplasmic reticulum membrane 0007268:chemical synaptic transmission 0007420:brain development 2001056:positive regulation of cysteine-type endopeptidase activity 0015276:ligand-gated ion channel activity 0007215:glutamate receptor signaling pathway 0016595:glutamate binding 0014069:postsynaptic density 0007611:learning or memory 2000310:regulation of NMDA receptor activity 0005737:cytoplasm 0097553:calcium ion transmembrane import into cytosol 0045211:postsynaptic membrane 0098976:excitatory chemical synaptic transmission 0000165:MAPK cascade 0043005:neuron projection 0005887:integral component of plasma membrane 0060079:excitatory postsynaptic potential 0005886:plasma membrane 0005764:lysosome 0048013:ephrin receptor signaling pathway 0051290:protein heterotetramerization 0022849:glutamate-gated calcium ion channel activity 0005856:cytoskeleton 1901216:positive regulation of neuron death 0098839:postsynaptic density membrane 0009986:cell surface 0060291:long-term synaptic potentiation 0008270:zinc ion binding 0045471:response to ethanol 0016594:glycine binding 0097060:synaptic membrane
PDB	7KL1 ; 5EWJ ; 6XDU ; 5EWL ; 1S2S ; 2IPV ; 7KL0 ; 1S11 ; 6XDL ; 7KL2 ; 7KL4 ; 6XOE ; 6XBX ; 5EWM ; 6XBP
Drugbank	DB06738 ; DB00659 ; DB13146 ; DB00289 ; DB00843 ; DB09481 ; DB00874 ; DB00454 ; DB05956 ; DB00949 ; DB00502 ; DB00312 ; DB06741 ; DB01520 ; DB06077 ; DB01238 ; DB00142 ; DB06151 ; DB08954 ; DB00193 ; DB09409 ; DB00418 ; DB01708 ; DB01043 ; DB00228 ; DB01956 ; DB00333 ; DB04896 ; DB01174 ; DB11823
KEGG	hsa:2904

Type

Detail

Target ID

T18RS6

Protein Name

Glutamate receptor ionotropic, NMDA 2B

Uniprot ID

Q13224

Protein Name Alias

GluN2B

Gene ID

2904

Gene Symbol

GRIN2B

Gene Alias

NMDAR2B

TTD

T76414: Successful target

Pfam

PF10613 ; PF01094 ; PF10565 ; PF00060

0048167:regulation of synaptic plasticity

0007275:multicellular organism development

1902951:negative regulation of dendritic spine maintenance

0038023:signaling receptor activity

0005770:late endosome

0017146:NMDA selective glutamate receptor complex

0001540:amyloid-beta binding

0004972:NMDA glutamate receptor activity

0005789:endoplasmic reticulum membrane

0007268:chemical synaptic transmission

0007420:brain development

2001056:positive regulation of cysteine-type endopeptidase activity

0015276:ligand-gated ion channel activity

0007215:glutamate receptor signaling pathway

0016595:glutamate binding

0014069:postsynaptic density

0007611:learning or memory

2000310:regulation of NMDA receptor activity

0005737:cytoplasm

0097553:calcium ion transmembrane import into cytosol

0045211:postsynaptic membrane

0098976:excitatory chemical synaptic transmission

0000165:MAPK cascade

0043005:neuron projection

0005887:integral component of plasma membrane

0060079:excitatory postsynaptic potential

0005886:plasma membrane

0005764:lysosome

0048013:ephrin receptor signaling pathway

0051290:protein heterotetramerization

0022849:glutamate-gated calcium ion channel activity

0005856:cytoskeleton

1901216:positive regulation of neuron death

0098839:postsynaptic density membrane

0009986:cell surface

0060291:long-term synaptic potentiation

0008270:zinc ion binding

0045471:response to ethanol

0016594:glycine binding

0097060:synaptic membrane

PDB

7KL1 ; 5EWJ ; 6XDU ; 5EWL ; 1S2S ; 2IPV ; 7KL0 ; 1S11 ; 6XDL ; 7KL2 ; 7KL4 ; 6XOE ; 6XBX ; 5EWM ; 6XBP

Drugbank

DB06738 ; DB00659 ; DB13146 ; DB00289 ; DB00843 ; DB09481 ; DB00874 ; DB00454 ; DB05956 ; DB00949 ; DB00502 ; DB00312 ; DB06741 ; DB01520 ; DB06077 ; DB01238 ; DB00142 ; DB06151 ; DB08954 ; DB00193 ; DB09409 ; DB00418 ; DB01708 ; DB01043 ; DB00228 ; DB01956 ; DB00333 ; DB04896 ; DB01174 ; DB11823

KEGG

hsa:2904

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0683	Xiu Xian Ju	绣线菊	Japanese spiraea	Spiraea japonica
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0416	Shan Shen	山参	NA	Panax ginseng
H0864	Cu Jiang Cao	酢浆草	Creeping oxalis	Oxalis corniculata
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0899	Chui Pen Cao Qing Gao	垂盆草清膏	all - grass of stringy stonecrop	Sedum sarmentosum
H0257	Mo Gu	蘑菇	Mushroom	Agaricus campestris
H0898	Chui Pen Cao	垂盆草	all - grass of stringy stonecrop	Sedum sarmentosum
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 19)