HIT-result

Target Description

Type	Detail
Target ID	T71V6E
Protein Name	Serine/threonine-protein kinase PAK 1
Uniprot ID	Q13153
Protein Name Alias	EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
Gene ID	5058
Gene Symbol	PAK1
Gene Alias	NA
TTD	T37961: Research target
Pfam	PF00786 ; PF00069
GO	0001726:ruffle 0045773:positive regulation of axon extension 0033148:positive regulation of intracellular estrogen receptor signaling pathway 0106311:protein threonine kinase activity 0032147:activation of protein kinase activity 0048013:ephrin receptor signaling pathway 0005829:cytosol 1904707:positive regulation of vascular associated smooth muscle cell proliferation 0030425:dendrite 0001934:positive regulation of protein phosphorylation 0050852:T cell receptor signaling pathway 0032991:protein-containing complex 0051496:positive regulation of stress fiber assembly 0031295:T cell costimulation 0004672:protein kinase activity 0061052:negative regulation of cell growth involved in cardiac muscle cell development 1904754:positive regulation of vascular associated smooth muscle cell migration 0030018:Z disc 0006974:cellular response to DNA damage stimulus 0006887:exocytosis 0050770:regulation of axonogenesis 0042802:identical protein binding 0005694:chromosome 0005654:nucleoplasm 0002223:stimulatory C-type lectin receptor signaling pathway 0060244:negative regulation of cell proliferation involved in contact inhibition 0106310:protein serine kinase activity 0048012:hepatocyte growth factor receptor signaling pathway 0048812:neuron projection morphogenesis 0010763:positive regulation of fibroblast migration 0006468:protein phosphorylation 0031965:nuclear membrane 0014704:intercalated disc 0005524:ATP binding 0001666:response to hypoxia 0038096:Fc-gamma receptor signaling pathway involved in phagocytosis 0043507:positive regulation of JUN kinase activity 0006915:apoptotic process 0031532:actin cytoskeleton reorganization 0033138:positive regulation of peptidyl-serine phosphorylation 0030335:positive regulation of cell migration 0004674:protein serine/threonine kinase activity 0005925:focal adhesion 0030027:lamellipodium 0016477:cell migration 0038095:Fc-epsilon receptor signaling pathway 0005518:collagen binding 0021549:cerebellum development 0005884:actin filament 0031098:stress-activated protein kinase signaling cascade 0090063:positive regulation of microtubule nucleation 0005886:plasma membrane 0031116:positive regulation of microtubule polymerization 0046777:protein autophosphorylation 0006338:chromatin remodeling 0030424:axon 0090314:positive regulation of protein targeting to membrane 0042060:wound healing 0019901:protein kinase binding 0032869:cellular response to insulin stimulus 0008284:positive regulation of cell population proliferation 0005911:cell-cell junction 0032587:ruffle membrane 0005737:cytoplasm 0043015:gamma-tubulin binding 0048754:branching morphogenesis of an epithelial tube 0016310:phosphorylation 0030010:establishment of cell polarity 0046628:positive regulation of insulin receptor signaling pathway
PDB	4P90 ; 3Q52 ; 4ZY4 ; 1YHV ; 5KBR ; 4EQC ; 3Q4Z ; 1F3M ; 3Q53 ; 3FY0 ; 5DEW ; 1YHW ; 4ZLO ; 2QME ; 4ZJJ ; 6B16 ; 4O0T ; 5DFP ; 5IME ; 1ZSG ; 4ZY5 ; 5KBQ ; 3DVP ; 4DAW ; 2HY8 ; 4ZJI ; 4ZY6 ; 5DEY ; 3FXZ ; 4O0R
Drugbank	DB12010
KEGG	hsa:5058

Type

Detail

Target ID

T71V6E

Protein Name

Serine/threonine-protein kinase PAK 1

Uniprot ID

Q13153

Protein Name Alias

EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK

Gene ID

5058

Gene Symbol

PAK1

Gene Alias

TTD

T37961: Research target

Pfam

PF00786 ; PF00069

0001726:ruffle

0045773:positive regulation of axon extension

0033148:positive regulation of intracellular estrogen receptor signaling pathway

0106311:protein threonine kinase activity

0032147:activation of protein kinase activity

0048013:ephrin receptor signaling pathway

0005829:cytosol

1904707:positive regulation of vascular associated smooth muscle cell proliferation

0030425:dendrite

0001934:positive regulation of protein phosphorylation

0050852:T cell receptor signaling pathway

0032991:protein-containing complex

0051496:positive regulation of stress fiber assembly

0031295:T cell costimulation

0004672:protein kinase activity

0061052:negative regulation of cell growth involved in cardiac muscle cell development

1904754:positive regulation of vascular associated smooth muscle cell migration

0030018:Z disc

0006974:cellular response to DNA damage stimulus

0006887:exocytosis

0050770:regulation of axonogenesis

0042802:identical protein binding

0005694:chromosome

0005654:nucleoplasm

0002223:stimulatory C-type lectin receptor signaling pathway

0060244:negative regulation of cell proliferation involved in contact inhibition

0106310:protein serine kinase activity

0048012:hepatocyte growth factor receptor signaling pathway

0048812:neuron projection morphogenesis

0010763:positive regulation of fibroblast migration

0006468:protein phosphorylation

0031965:nuclear membrane

0014704:intercalated disc

0005524:ATP binding

0001666:response to hypoxia

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0043507:positive regulation of JUN kinase activity

0006915:apoptotic process

0031532:actin cytoskeleton reorganization

0033138:positive regulation of peptidyl-serine phosphorylation

0030335:positive regulation of cell migration

0004674:protein serine/threonine kinase activity

0005925:focal adhesion

0030027:lamellipodium

0016477:cell migration

0038095:Fc-epsilon receptor signaling pathway

0005518:collagen binding

0021549:cerebellum development

0005884:actin filament

0031098:stress-activated protein kinase signaling cascade

0090063:positive regulation of microtubule nucleation

0005886:plasma membrane

0031116:positive regulation of microtubule polymerization

0046777:protein autophosphorylation

0006338:chromatin remodeling

0030424:axon

0090314:positive regulation of protein targeting to membrane

0042060:wound healing

0019901:protein kinase binding

0032869:cellular response to insulin stimulus

0008284:positive regulation of cell population proliferation

0005911:cell-cell junction

0032587:ruffle membrane

0005737:cytoplasm

0043015:gamma-tubulin binding

0048754:branching morphogenesis of an epithelial tube

0016310:phosphorylation

0030010:establishment of cell polarity

0046628:positive regulation of insulin receptor signaling pathway

PDB

4P90 ; 3Q52 ; 4ZY4 ; 1YHV ; 5KBR ; 4EQC ; 3Q4Z ; 1F3M ; 3Q53 ; 3FY0 ; 5DEW ; 1YHW ; 4ZLO ; 2QME ; 4ZJJ ; 6B16 ; 4O0T ; 5DFP ; 5IME ; 1ZSG ; 4ZY5 ; 5KBQ ; 3DVP ; 4DAW ; 2HY8 ; 4ZJI ; 4ZY6 ; 5DEY ; 3FXZ ; 4O0R

Drugbank

DB12010

KEGG

hsa:5058

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 17)