Target Description

Type Detail
Target ID T71V6E
Protein Name Serine/threonine-protein kinase PAK 1
Uniprot ID Q13153
Protein Name Alias EC 2.7.11.1;  Alpha-PAK;  p21-activated kinase 1;  PAK-1;  p65-PAK
Gene ID 5058
Gene Symbol PAK1
Gene Alias NA
TTD T37961: Research target
Pfam PF00786 ; PF00069
GO
0001726:ruffle

0045773:positive regulation of axon extension

0033148:positive regulation of intracellular estrogen receptor signaling pathway

0106311:protein threonine kinase activity

0032147:activation of protein kinase activity

0048013:ephrin receptor signaling pathway

0005829:cytosol

1904707:positive regulation of vascular associated smooth muscle cell proliferation

0030425:dendrite

0001934:positive regulation of protein phosphorylation

0050852:T cell receptor signaling pathway

0032991:protein-containing complex

0051496:positive regulation of stress fiber assembly

0031295:T cell costimulation

0004672:protein kinase activity

0061052:negative regulation of cell growth involved in cardiac muscle cell development

1904754:positive regulation of vascular associated smooth muscle cell migration

0030018:Z disc

0006974:cellular response to DNA damage stimulus

0006887:exocytosis

0050770:regulation of axonogenesis

0042802:identical protein binding

0005694:chromosome

0005654:nucleoplasm

0002223:stimulatory C-type lectin receptor signaling pathway

0060244:negative regulation of cell proliferation involved in contact inhibition

0106310:protein serine kinase activity

0048012:hepatocyte growth factor receptor signaling pathway

0048812:neuron projection morphogenesis

0010763:positive regulation of fibroblast migration

0006468:protein phosphorylation

0031965:nuclear membrane

0014704:intercalated disc

0005524:ATP binding

0001666:response to hypoxia

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0043507:positive regulation of JUN kinase activity

0006915:apoptotic process

0031532:actin cytoskeleton reorganization

0033138:positive regulation of peptidyl-serine phosphorylation

0030335:positive regulation of cell migration

0004674:protein serine/threonine kinase activity

0005925:focal adhesion

0030027:lamellipodium

0016477:cell migration

0038095:Fc-epsilon receptor signaling pathway

0005518:collagen binding

0021549:cerebellum development

0005884:actin filament

0031098:stress-activated protein kinase signaling cascade

0090063:positive regulation of microtubule nucleation

0005886:plasma membrane

0031116:positive regulation of microtubule polymerization

0046777:protein autophosphorylation

0006338:chromatin remodeling

0030424:axon

0090314:positive regulation of protein targeting to membrane

0042060:wound healing

0019901:protein kinase binding

0032869:cellular response to insulin stimulus

0008284:positive regulation of cell population proliferation

0005911:cell-cell junction

0032587:ruffle membrane

0005737:cytoplasm

0043015:gamma-tubulin binding

0048754:branching morphogenesis of an epithelial tube

0016310:phosphorylation

0030010:establishment of cell polarity

0046628:positive regulation of insulin receptor signaling pathway

PDB 4P90 ; 3Q52 ; 4ZY4 ; 1YHV ; 5KBR ; 4EQC ; 3Q4Z ; 1F3M ; 3Q53 ; 3FY0 ; 5DEW ; 1YHW ; 4ZLO ; 2QME ; 4ZJJ ; 6B16 ; 4O0T ; 5DFP ; 5IME ; 1ZSG ; 4ZY5 ; 5KBQ ; 3DVP ; 4DAW ; 2HY8 ; 4ZJI ; 4ZY6 ; 5DEY ; 3FXZ ; 4O0R
Drugbank DB12010
KEGG hsa:5058

Related Compounds  (Total: 3)

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C0213
Name: Metformin
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C0247
Name: Nicotine
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C0325
Name: Progesterone


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