Target Description
| Type | Detail |
|---|---|
| Target ID | T18C4B |
| Protein Name | Methylated-DNA--protein-cysteine methyltransferase |
| Uniprot ID |
P16455 |
| Protein Name Alias | EC 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase |
| Gene ID |
4255 |
| Gene Symbol | MGMT |
| Gene Alias | NA |
| TTD | T24587: Clinical Trial target |
| Pfam | PF02870 ; PF01035 |
| GO |
0003677:DNA binding
0005634:nucleus 0016020:membrane 0006281:DNA repair 0005654:nucleoplasm 0046872:metal ion binding 0006266:DNA ligation 0008168:methyltransferase activity 0006307:DNA dealkylation involved in DNA repair 0043066:negative regulation of apoptotic process 0009008:DNA-methyltransferase activity 0003908:methylated-DNA-[protein]-cysteine S-methyltransferase activity 2000781:positive regulation of double-strand break repair |
| PDB | 1YFH ; 1QNT ; 1EH6 ; 1EH7 ; 1EH8 ; 1T38 ; 1T39 |
| Drugbank | DB01593 ; DB14533 ; DB04531 ; DB00151 ; DB11831 ; DB14487 ; DB02216 ; DB14548 |
| KEGG | hsa:4255 |
Related Herbs (Total: 15)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0925 | Da Fu Zi | 大腹子 | Areca palm | Areca catechu |
| H1134 | Bai Jiang Can | 白僵蚕 | Silkworm larva | Bombyx mori |
| H1176 | Hei Hu Jiao | 黑胡椒 | Black pepper | Piper nigrum |
| H0924 | Da Fu Pi | 大腹皮 | pericarp of betelnutpalm | Pericarpium arecae |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0476 | Can E | 蚕蛾 | Silkworm | Bombyx mori |
| H0490 | Can Jian | 蚕茧 | Silk cocoon | Bombyx mori |
| H0495 | Can Sha | 蚕砂 | Silkworm excrement | Bombyx mori |
| H1077 | Bai Hu Jiao | 白胡椒 | white pepper | Piper nigrum |
| H0500 | Can Yong | 蚕蛹 | Silkworm chrysalis | Bombyx mori |
| H0033 | Jiao Bing Lang | 焦槟榔 | Charred areca seed | Semen arecae preparata |
| H1204 | Hu Jiao | 胡椒 | Black pepper | Piper nigrum |
| H0408 | Bing Lang | 槟榔 | Betenutpalm | Areca catechu |