Compound Description
| ID: C0392 | Common name: Scopoletin |
| IUPAC: 7-hydroxy-6-methoxychromen-2-one | CAS: CAS:92-61-5 |
| Chembl ID: CHEMBL71851 | Pubchem ID: CID:5280460 |
| Formula: C10H8O4 | TCM-ID: TCMC2051 |
| Smiles: COc1cc2ccc(=O)oc2cc1O | |
| Alias:
Coumarin, 7-hydroxy-6-methoxy-;
7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxy-7-hydroxycoumarin; 6-Methylesculetin; 6-O-Methylesculetin; 7-Hydroxy-6-methoxycoumarin; Buxuletin; Chrysatropic acid; Escopoletin; Esculetin 6-methyl ether; Gelseminic acid; Murrayetin; NSC 405647; Scopoletin; Scopoletine; Scopoletol; β-Methylesculetin |
Structure:
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Related Targets (Total: 5)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
A | 1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
B | 1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 106)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0613 | Wu Yue Ai | 五月艾 | Artemisia | Artemisia princeps |
| H0246 | Mi Ma Huang | 蜜麻黄 | Ephedra equisetin | Ephedra sinica |
| H1090 | Gao Ben | 藁本 | Chinese ligusticum | Ligusticum sinense |
| H0198 | Ma Huang Gao | 麻黄膏 | Chinese ephedra | Ephedra sinica |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0344 | Qing Guo | 青果 | Olive | Canarium album |
| H0712 | Yan Jing She | 眼镜蛇 | NA | Naja naja |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H1237 | Huang Hua Ren | 黄花稔 | Acute sida | Sida acuta |
| H0957 | Dang Gui Teng | 当归藤 | NA | Embelia parviflora |
| H0239 | Bei Sha Shen | 北沙参 | Coastal glehnia | Glehnia littoralis |
| H0188 | Lv Cao | 葎草 | Japanese hop | Humulus japonicus |
| H0142 | Liang Jiang | 良姜 | NA | Alpinia officinarum |
| H0793 | Zhao Shan Bai | 照山白 | Manchurian rhododendron | Rhododendron micranthum |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0200 | Ma Huang Gen | 麻黄根 | Chinese ephedra root | Ephedra sinica |
| H0154 | Ai Ye You | 艾叶油 | Argy wormwood leaf | Artemisia argyi |
| H0345 | Qing Guo Tan | 青果炭 | white olive | Canarium album |
| H0242 | Bei Sha Shen Liu Jin Gao | 北沙参流浸膏 | Glehnia littoralis | Glehnia littoralis |
| H0984 | Dian Qie Liu Jin Gao | 颠茄流浸膏 | belladonna | Atropa belladonna |
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H1138 | Bai Jiang Cao | 败酱草 | All - grass of dahurian patrinia | Thlaspi arvense |
| H0902 | Chun Pi | 椿皮 | Ailanthus bark, tree of heaven bark | Ailanthi cortex |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H1009 | Du Huo | 独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H0988 | Ding Gong Teng | 丁公藤 | Obtuseleaf Erycibe Stem | Erycibe obtusifolia |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H0868 | Chuan Du Huo | 川独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H0207 | Ma Wei Song Shu Gen | 马尾松树根 | NA | Pinus massoniana |
| H0500 | Can Yong | 蚕蛹 | Silkworm chrysalis | Bombyx mori |
| H0691 | Xue Lian Hua | 雪莲花 | Snow lotus | Saussurea involucrata |
| H0974 | Di Jin Cao | 地锦草 | Humifuse euphorbia | Euphorbia humifusa |
| H0754 | Ying Bu Bo | 鹰不泊 | Avicenna’s pricklyash | Zanthoxylum avicennae |
| H0395 | Sang Shen Qing Gao | 桑葚清膏 | Mulberry | Morus alba |
| H0863 | Zui Xian Tao | 醉仙桃 | jimsonweed | Datura stramonium |
| H0181 | Luo Bu Ma | 罗布麻 | Dogbane | Apocynum venetum |
| H0206 | Ma Wei Song Gen | 马尾松根 | NA | Pinus massoniana |
| H0223 | Man Tuo Luo Jin Gao | 曼陀罗浸膏 | Jimsonweed | Datura stramonium |
| H0201 | Ma Huang Jin Gao | 麻黄浸膏 | Chinese ephedra | Ephedra sinica |
| H1235 | Huang Hao | 黄蒿 | Virg ate wormwood | Artemisia scoparia |
| H1030 | Fang Feng | 防风 | Divaricate saposhnikovia | Saposhnikovia divaricata |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H1082 | Gan Lan | 橄榄 | Cabbage | Canarium album |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H0323 | Qian Hu | 前胡 | Common hogfennel | Angelica decursiva |
| H0862 | Zuan Gu Feng | 钻骨风 | NA | Piper hancei |
| H0983 | Dian Qie Jin Gao | 颠茄浸膏 | belladonna | Atropa belladonna |
| H0865 | Chuan Bi Feng | 穿壁风 | hance pepper stem and leaf | Piper hancei |
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H0507 | Song Zhi | 松脂 | Rosin | Pinus massoniana |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0393 | Sang Shen | 桑葚 | Mulberry | Morus alba |
| H1093 | Gao Liang Jiang You | 高良姜油 | Lesser galangal | Alpinia officinarum |
| H0826 | Chu Mu Dan | 臭牡丹 | rose glorybower | Clerodendrum bungei |
| H0730 | Ye Ma Zhui | 野马追 | NA | Eupatorium lindleyanum |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H0251 | Mian Bi Xie | 绵萆薢 | Sevenlobed yamn rhizome | Dioscorea spongiosa |
| H0389 | Sang Bai Pi Liu Jin Gao | 桑白皮流浸膏 | Prepared root-bark white mulberry | Cortex mori radicis praeparata |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H0533 | Teng Ku Shen | 藤苦参 | NA | Sophora flavescens |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H1041 | Feng Qie Hua | 枫茄花 | Jimsonweed | Datura stramonium |
| H0726 | Ye Dian Qie | 野颠茄 | Soda-apple nightshade | Atropa belladonna |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0222 | Man Tuo Luo | 曼陀罗 | Jimsonweed | Datura stramonium |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H1134 | Bai Jiang Can | 白僵蚕 | Silkworm larva | Bombyx mori |
| H0103 | Ai Ye | 艾叶 | Argy wormwood leaf | Artemisia argyi |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0546 | Tian Shan Xue Lian Hua | 天山雪莲花 | NA | Saussurea involucrata |
| H0214 | Bei He Huan | 北合欢 | Albizia | Albizia julibrissin |
| H0379 | Bian Xu | 萹蓄 | Common knotgrass | Polygonum aviculare |
| H0197 | Ma Huang | 麻黄 | Chinese ephedra | Ephedra sinica |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0764 | Yu Xing Cao | 鱼腥草 | Heartleaf houttuynia | Houttuynia cordata |
| H0705 | Yan Hu Lu Ba | 盐胡芦巴 | Fenugreek | Trigonella foenum-graecum |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0642 | Xiang Jia Pi | 香加皮 | Chinese silkvine root-bark | Periploca sepium |
| H0812 | Sang Bai Pi | 桑白皮 | Prepared root-bark white mulberry | Cortex mori radicis praeparata |
| H0975 | Di Mian Cao | 地绵草 | NA | Euphorbia humifusa |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0506 | Song Xiang | 松香 | Colophony | Pinus massoniana |
| H0490 | Can Jian | 蚕茧 | Silk cocoon | Bombyx mori |
| H0495 | Can Sha | 蚕砂 | Silkworm excrement | Bombyx mori |
| H0536 | Tian Di Ding | 甜地丁 | Manyflower gueldenstaedtid herb | Viola philippica |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H0111 | Ku Shen | 苦参 | Lightyellow sophora | Sophora flavescens |
| H0575 | Tu Ku Shen | 土苦参 | all-grass of hooker winghead | Sophora flavescens |
| H0617 | Qian Cao Teng | 茜草藤 | NA | Rubia cordifolia |
| H1092 | Gao Liang Jiang | 高良姜 | Lesser galangal | Alpinia officinarum |
| H0476 | Can E | 蚕蛾 | Silkworm | Bombyx mori |
| H0690 | Xue Lian | 雪莲 | Snow lotus | Saussurea involucrata |
| H0755 | Ying Shan Hong | 映山红 | Korean rhododendron | Rhododendron mucronulatum |
| H0394 | Sang Shen Jin Gao | 桑葚浸膏 | Mulberry | Morus alba |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
Ckey description of the interaction between compound and target