HIT-result

Target Description

Type	Detail
Target ID	T56X9Z
Protein Name	Myeloid cell surface antigen CD33
Uniprot ID	P20138
Protein Name Alias	Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33
Gene ID	945
Gene Symbol	CD33
Gene Alias	SIGLEC3
TTD	T38950: Successful target
Pfam	PF00047 ; PF07686
GO	0150102:negative regulation of monocyte activation 0038023:signaling receptor activity 0051926:negative regulation of calcium ion transport 0007155:cell adhesion 0033691:sialic acid binding 0050714:positive regulation of protein secretion 1903615:positive regulation of protein tyrosine phosphatase activity 0008285:negative regulation of cell population proliferation 0070821:tertiary granule membrane 0050776:regulation of immune response 0005887:integral component of plasma membrane 0002765:immune response-inhibiting signal transduction 0005886:plasma membrane 0032717:negative regulation of interleukin-8 production 0007267:cell-cell signaling 0043312:neutrophil degranulation 0030246:carbohydrate binding 0009986:cell surface 0005794:Golgi apparatus 0007165:signal transduction 0098609:cell-cell adhesion 0032720:negative regulation of tumor necrosis factor production 0005777:peroxisome 0005654:nucleoplasm 0009897:external side of plasma membrane 0035579:specific granule membrane 0019903:protein phosphatase binding 0032691:negative regulation of interleukin-1 beta production
PDB	7AW6 ; 5J06 ; 5IHB ; 5J0B ; 6D49 ; 6TL8 ; 6D48 ; 6D4A
Drugbank	DB00056 ; DB06318
KEGG	hsa:945

Type

Detail

Target ID

T56X9Z

Protein Name

Myeloid cell surface antigen CD33

Uniprot ID

P20138

Protein Name Alias

Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33

Gene ID

945

Gene Symbol

CD33

Gene Alias

SIGLEC3

TTD

T38950: Successful target

Pfam

PF00047 ; PF07686

0150102:negative regulation of monocyte activation

0038023:signaling receptor activity

0051926:negative regulation of calcium ion transport

0007155:cell adhesion

0033691:sialic acid binding

0050714:positive regulation of protein secretion

1903615:positive regulation of protein tyrosine phosphatase activity

0008285:negative regulation of cell population proliferation

0070821:tertiary granule membrane

0050776:regulation of immune response

0005887:integral component of plasma membrane

0002765:immune response-inhibiting signal transduction

0005886:plasma membrane

0032717:negative regulation of interleukin-8 production

0007267:cell-cell signaling

0043312:neutrophil degranulation

0030246:carbohydrate binding

0009986:cell surface

0005794:Golgi apparatus

0007165:signal transduction

0098609:cell-cell adhesion

0032720:negative regulation of tumor necrosis factor production

0005777:peroxisome

0005654:nucleoplasm

0009897:external side of plasma membrane

0035579:specific granule membrane

0019903:protein phosphatase binding

0032691:negative regulation of interleukin-1 beta production

PDB

7AW6 ; 5J06 ; 5IHB ; 5J0B ; 6D49 ; 6TL8 ; 6D48 ; 6D4A

Drugbank

DB00056 ; DB06318

KEGG

hsa:945

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0222	Man Tuo Luo	曼陀罗	Jimsonweed	Datura stramonium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0215	Mai Ya	麦芽	Barley germinating fruit	Hordeum vulgare
H1041	Feng Qie Hua	枫茄花	Jimsonweed	Datura stramonium
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0863	Zui Xian Tao	醉仙桃	jimsonweed	Datura stramonium
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0223	Man Tuo Luo Jin Gao	曼陀罗浸膏	Jimsonweed	Datura stramonium
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 13)