HIT-result

Target Description

Type	Detail
Target ID	T12IEI
Protein Name	Cadherin-2
Uniprot ID	P19022
Protein Name Alias	CDw325; Neural cadherin; N-cadherin; CD antigen CD325
Gene ID	1000
Gene Symbol	CDH2
Gene Alias	CDHN; NCAD
TTD	T16868: Clinical Trial target
Pfam	PF08758 ; PF00028 ; PF01049
GO	0019903:protein phosphatase binding 0014704:intercalated disc 0005886:plasma membrane 0099059:integral component of presynaptic active zone membrane 0019901:protein kinase binding 0030054:cell junction 0021987:cerebral cortex development 0070445:regulation of oligodendrocyte progenitor proliferation 0005912:adherens junction 0009986:cell surface 0007420:brain development 0098609:cell-cell adhesion 2000809:positive regulation of synaptic vesicle clustering 0005916:fascia adherens 0030027:lamellipodium 0045296:cadherin binding 0090497:mesenchymal cell migration 0003323:type B pancreatic cell development 0007043:cell-cell junction assembly 0007157:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 0048872:homeostasis of number of cells 0045177:apical part of cell 0097118:neuroligin clustering involved in postsynaptic membrane assembly 0097150:neuronal stem cell population maintenance 0098742:cell-cell adhesion via plasma-membrane adhesion molecules 0005911:cell-cell junction 0051149:positive regulation of muscle cell differentiation 0016327:apicolateral plasma membrane 0005925:focal adhesion 0008013:beta-catenin binding 0034332:adherens junction organization 0007416:synapse assembly 0062023:collagen-containing extracellular matrix 0042383:sarcolemma 0051146:striated muscle cell differentiation 0044331:cell-cell adhesion mediated by cadherin 0050770:regulation of axonogenesis 0045295:gamma-catenin binding 0043687:post-translational protein modification 0007155:cell adhesion 0010001:glial cell differentiation 0035995:detection of muscle stretch 0016323:basolateral plasma membrane 0044853:plasma membrane raft 0044267:cellular protein metabolic process 0005509:calcium ion binding 0045294:alpha-catenin binding 1902897:regulation of postsynaptic density protein 95 clustering 0007156:homophilic cell adhesion via plasma membrane adhesion molecules 0005788:endoplasmic reticulum lumen 0016324:apical plasma membrane 0060019:radial glial cell differentiation 0042802:identical protein binding 0048854:brain morphogenesis 0005887:integral component of plasma membrane 0014069:postsynaptic density 0005737:cytoplasm 0043005:neuron projection 0016342:catenin complex 0090090:negative regulation of canonical Wnt signaling pathway 0099060:integral component of postsynaptic specialization membrane 0048514:blood vessel morphogenesis 0072659:protein localization to plasma membrane 0051966:regulation of synaptic transmission, glutamatergic 0060563:neuroepithelial cell differentiation 0043410:positive regulation of MAPK cascade 0014032:neural crest cell development 0016339:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
PDB	NA
Drugbank	NA
KEGG	hsa:1000

Type

Detail

Target ID

T12IEI

Protein Name

Cadherin-2

Uniprot ID

P19022

Protein Name Alias

CDw325; Neural cadherin; N-cadherin; CD antigen CD325

Gene ID

1000

Gene Symbol

CDH2

Gene Alias

CDHN; NCAD

TTD

T16868: Clinical Trial target

Pfam

PF08758 ; PF00028 ; PF01049

0019903:protein phosphatase binding

0014704:intercalated disc

0005886:plasma membrane

0099059:integral component of presynaptic active zone membrane

0019901:protein kinase binding

0030054:cell junction

0021987:cerebral cortex development

0070445:regulation of oligodendrocyte progenitor proliferation

0005912:adherens junction

0009986:cell surface

0007420:brain development

0098609:cell-cell adhesion

2000809:positive regulation of synaptic vesicle clustering

0005916:fascia adherens

0030027:lamellipodium

0045296:cadherin binding

0090497:mesenchymal cell migration

0003323:type B pancreatic cell development

0007043:cell-cell junction assembly

0007157:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

0048872:homeostasis of number of cells

0045177:apical part of cell

0097118:neuroligin clustering involved in postsynaptic membrane assembly

0097150:neuronal stem cell population maintenance

0098742:cell-cell adhesion via plasma-membrane adhesion molecules

0005911:cell-cell junction

0051149:positive regulation of muscle cell differentiation

0016327:apicolateral plasma membrane

0005925:focal adhesion

0008013:beta-catenin binding

0034332:adherens junction organization

0007416:synapse assembly

0062023:collagen-containing extracellular matrix

0042383:sarcolemma

0051146:striated muscle cell differentiation

0044331:cell-cell adhesion mediated by cadherin

0050770:regulation of axonogenesis

0045295:gamma-catenin binding

0043687:post-translational protein modification

0007155:cell adhesion

0010001:glial cell differentiation

0035995:detection of muscle stretch

0016323:basolateral plasma membrane

0044853:plasma membrane raft

0044267:cellular protein metabolic process

0005509:calcium ion binding

0045294:alpha-catenin binding

1902897:regulation of postsynaptic density protein 95 clustering

0007156:homophilic cell adhesion via plasma membrane adhesion molecules

0005788:endoplasmic reticulum lumen

0016324:apical plasma membrane

0060019:radial glial cell differentiation

0042802:identical protein binding

0048854:brain morphogenesis

0005887:integral component of plasma membrane

0014069:postsynaptic density

0005737:cytoplasm

0043005:neuron projection

0016342:catenin complex

0090090:negative regulation of canonical Wnt signaling pathway

0099060:integral component of postsynaptic specialization membrane

0048514:blood vessel morphogenesis

0072659:protein localization to plasma membrane

0051966:regulation of synaptic transmission, glutamatergic

0060563:neuroepithelial cell differentiation

0043410:positive regulation of MAPK cascade

0014032:neural crest cell development

0016339:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

PDB

Drugbank

KEGG

hsa:1000

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0416	Shan Shen	山参	NA	Panax ginseng
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 37)