HIT-result

Type	Detail
Target ID	T92ZDN
Protein Name	GTPase KRas
Uniprot ID	P01116
Protein Name Alias	EC 3.6.5.2; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras
Gene ID	3845
Gene Symbol	KRAS
Gene Alias	KRAS2; RASK2
TTD	T48598: Clinical Trial target
Pfam	PF00071
GO	0019003:GDP binding 0042802:identical protein binding 0019002:GMP binding 0060441:epithelial tube branching involved in lung morphogenesis 0048169:regulation of long-term neuronal synaptic plasticity 0005925:focal adhesion 0048873:homeostasis of number of cells within a tissue 0043524:negative regulation of neuron apoptotic process 0005789:endoplasmic reticulum membrane 0005829:cytosol 0002223:stimulatory C-type lectin receptor signaling pathway 0008284:positive regulation of cell population proliferation 0001889:liver development 0035022:positive regulation of Rac protein signal transduction 0030036:actin cytoskeleton organization 0051092:positive regulation of NF-kappaB transcription factor activity 0000139:Golgi membrane 0031234:extrinsic component of cytoplasmic side of plasma membrane 0008542:visual learning 0032228:regulation of synaptic transmission, GABAergic 0045596:negative regulation of cell differentiation 0000165:MAPK cascade 0044877:protein-containing complex binding 0010628:positive regulation of gene expression 0001934:positive regulation of protein phosphorylation 0005886:plasma membrane 0021897:forebrain astrocyte development 0007265:Ras protein signal transduction 0045121:membrane raft 0005741:mitochondrial outer membrane 0030275:LRR domain binding 0051384:response to glucocorticoid 0038002:endocrine signaling 0003924:GTPase activity 0016020:membrane 0051146:striated muscle cell differentiation 0043406:positive regulation of MAP kinase activity 0005737:cytoplasm 0031647:regulation of protein stability 0005525:GTP binding 0007565:female pregnancy 0019221:cytokine-mediated signaling pathway 2000774:positive regulation of cellular senescence 0035900:response to isolation stress 0051000:positive regulation of nitric-oxide synthase activity 0051385:response to mineralocorticoid
PDB	6P8W ; 5VQ8 ; 5VQ1 ; 5VBM ; 6ARK ; 6B0V ; 6EPP ; 6TAN ; 6BOF ; 6QUU ; 6ZLI ; 4LRW ; 5TB5 ; 7ACH ; 6FA4 ; 5WPM ; 5OCO ; 6EPN ; 4M1Y ; 6O36 ; 6USX ; 6JTP ; 5VQ6 ; 6MBT ; 6PTW ; 6MBQ ; 4Q02 ; 6N2J ; 5O2S ; 6ZL5 ; 4PZY ; 5WHB ; 6JTN ; 6H47 ; 6QUV ; 6JTO ; 6VJJ ; 4DSO ; 6V65 ; 1KZP ; 6W4F ; 6ASE ; 6QUX ; 4DSN ; 5OCT ; 6GOM ; 5UQW ; 6GOG ; 1N4P ; 4EPR ; 1N4S ; 4M1O ; 6V6F ; 4EPT ; 6P0Z ; 5UFQ ; 6T5B ; 6OB2 ; 6GOF ; 5VPI ; 5YY1 ; 5O2T ; 6PQ3 ; 6TAM ; 6WGN ; 6O4Z ; 5MLB ; 1N4R ; 1D8E ; 6O46 ; 6OB3 ; 6PGP ; 6FA1 ; 6EPL ; 6XGU ; 6H46 ; 4Q01 ; 6YXW ; 3GFT ; 4Q03 ; 4LDJ ; 4LYH ; 4M22 ; 6UT0 ; 4WA7 ; 6QUW ; 6CCX ; 5TAR ; 6GJ5 ; 5WHD ; 6CC9 ; 7ACA ; 5VQ2 ; 6MNX ; 4TQA ; 5MLA ; 4LUC ; 6XHA ; 4EPV ; 1KZO ; 4EPY ; 5F2E ; 5UFE ; 6MTA ; 6CCH ; 5W22 ; 6EPM ; 6E6F ; 5US4 ; 6GQX ; 6XGV ; 6GQT ; 5V9U ; 5WLB ; 6CU6 ; 5V71 ; 6BP1 ; 6MQG ; 6FA3 ; 6GOD ; 5V6V ; 4LYF ; 6YR8 ; 5V9O ; 4EPW ; 1D8D ; 5YXZ ; 4M21 ; 5XCO ; 6B0Y ; 6E6G ; 6P8Y ; 6XHB ; 4NMM ; 6GOE ; 6USZ ; 6GQW ; 5WHE ; 6F76 ; 6MBU ; 4TQ9 ; 7ACF ; 6PGO ; 6N2K ; 4M1W ; 5OCG ; 6M9W ; 6OIM ; 1N4Q ; 4EPX ; 4OBE ; 6FA2 ; 6O4Y ; 6O51 ; 4M1T ; 6GQY ; 4L8G ; 5KYK ; 5UK9 ; 5VPY ; 6MQN ; 4QL3 ; 6V5L ; 6T5V ; 4LYJ ; 6ASA ; 5V6S ; 4M1S ; 4PZZ ; 6GJ8 ; 6O53 ; 6P8Z ; 5VP7 ; 5VQ0 ; 4LPK ; 5V9L ; 6EPO ; 6P8X ; 6GJ6 ; 5VPZ ; 6T5U ; 4LV6 ; 5WHA ; 6W4E ; 7ACQ ; 5USJ ; 6MS9 ; 6PTS ; 6GJ7
Drugbank	DB15569 ; DB07771 ; DB07780 ; DB15568
KEGG	hsa:3845

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0418	Shan Yin Chen	山茵陈	Capillary wormwood	Artemisia capillaris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0124	La Mei Hua	腊梅花	Wintersweet bud	Chimonanthus fragrans
H0149	Ling Mao Xiang	灵猫香	Civet	Viverra zibetha
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0273	Mu Tong	木通	Fiveleaf akebia	Akebia quinata
H0745	Yin Chen Hao	茵陈蒿	Capillary wormwood	Artemisia capillaris
H0585	Tu Yin Chen Hao	土茵陈蒿	Capillary wormwood	Artemisia capillaris
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0746	Yin Chen Hao Gan Jin Gao	茵陈蒿干浸膏	Capillary wormwood	Artemisia capillaris
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 21)