ID: C1207 | Common name: Calcitriol |
IUPAC: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol | CAS: CAS:32222-06-3 |
Chembl ID: CHEMBL846 | Pubchem ID: CID:5280453 |
Formula: C27H44O3 | TCM-ID: TCMC854 |
Smiles: O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(O)(C)C)C)C)/C1 | |
Alias:
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1α,3β,5Z,7E)-;
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol; 1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D; 1,25-Dihydroxyvitamin D3; 1a,25-Dihydroxyvitamin D3; 1α,25-(OH)2D3; 1α,25-Dihydroxycholecalciferol; 1α,25-Dihydroxyvitamin D3; 1α,25-Hydroxyl-vitamin D3; Calcijex; Calcitriol; DN 101; Dihydroxyvitamin D3; Panbonis; Ro 21-5535; Rocaltrol; Silkis; Solbone P; Soltriol; Topitriol; Toptriol |
Structure:
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Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
---|---|---|---|---|---|
T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
A | 1 Reference(s) |
T34ZK4 | Glutathione hydrolase 1 proenzyme | GGT1 |
P19440 |
A | 1 Reference(s) |
T41BYM | Fibroblast growth factor 23 | FGF23 |
Q9GZV9 |
A | 3 Reference(s) |
T85JI5 | Vitamin D3 receptor | VDR |
P11473 |
A | 11 Reference(s) |
T55J1X | Radiation-inducible immediate-early gene IEX-1 | IER3 |
P46695 |
A | 1 Reference(s) |
T38FFJ | Potassium voltage-gated channel subfamily H member 1 | KCNH1 |
O95259 |
B | 1 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
B | 1 Reference(s) |
T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
B | 1 Reference(s) |
T05DRQ | Receptor tyrosine-protein kinase erbB-4 | ERBB4 |
Q15303 |
B | 1 Reference(s) |
T15URL | Cathelicidin antimicrobial peptide | CAMP |
P49913 |
B | 2 Reference(s) |
T59Y35 | Advanced glycosylation end product-specific receptor | AGER |
Q15109 |
B | 2 Reference(s) |
T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
B | 1 Reference(s) |
T37YKZ | Endothelin receptor type B | EDNRB |
P24530 |
C | 1 Reference(s) |
T09ICL | Transient receptor potential cation channel subfamily V member 6 | TRPV6 |
Q9H1D0 |
C | 1 Reference(s) |
T56TFE | 5'-nucleotidase | NT5E |
P21589 |
C | 1 Reference(s) |
T88UDX | Lysine-specific demethylase 6B | KDM6B |
O15054 |
C | 1 Reference(s) |
T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
C | 1 Reference(s) |
T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
T75U40 | Cytotoxic T-lymphocyte protein 4 | CTLA4 |
P16410 |
C | 1 Reference(s) |
T33JS5 | CCN family member 2 | CCN2 |
P29279 |
C | 1 Reference(s) |
T74GHX | OX-2 membrane glycoprotein | CD200 |
P41217 |
C | 1 Reference(s) |
T37WQE | Kallikrein-5 | KLK5 |
Q9Y337 |
C | 1 Reference(s) |
T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
C | 1 Reference(s) |
T01QLH | Estrogen receptor | ESR1 |
P03372 |
C | 1 Reference(s) |
T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
C | 1 Reference(s) |
T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
C | 1 Reference(s) |
T64LXU | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CYP24A1 |
Q07973 |
C | 1 Reference(s) |
T38TP1 | Sodium-dependent phosphate transporter 2 | SLC20A2 |
Q08357 |
C | 1 Reference(s) |
T68EEP | Phospholipase D1 | PLD1 |
Q13393 |
C | 1 Reference(s) |
T47K8G | Podocalyxin | PODXL |
O00592 |
C | 1 Reference(s) |
T55JB4 | Fibroblast growth factor receptor 1 | FGFR1 |
P11362 |
C | 1 Reference(s) |
T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
C | 1 Reference(s) |
T06AO4 | Membrane cofactor protein | CD46 |
P15529 |
C | 1 Reference(s) |
T82P0Z | Renin | REN |
P00797 |
C | 1 Reference(s) |
T47WT6 | Breast cancer type 1 susceptibility protein | BRCA1 |
P38398 |
C | 1 Reference(s) |
T52I9S | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CYP27B1 |
O15528 |
C | 1 Reference(s) |