Compound Description

ID:   C1207 Common name:   Calcitriol
IUPAC:  (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol CAS:  CAS:32222-06-3
Chembl ID:   CHEMBL846 Pubchem ID:   CID:5280453
Formula:  C27H44O3 TCM-ID:  TCMC854
Smiles:  O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(O)(C)C)C)C)/C1
Alias:

9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1α,3β,5Z,7E)-;

(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;

(3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol;

1,25-Dihydroxycholecalciferol;

1,25-Dihydroxyvitamin D;

1,25-Dihydroxyvitamin D3;

1a,25-Dihydroxyvitamin D3;

1α,25-(OH)2D3;

1α,25-Dihydroxycholecalciferol;

1α,25-Dihydroxyvitamin D3;

1α,25-Hydroxyl-vitamin D3;

Calcijex;

Calcitriol;

DN 101;

Dihydroxyvitamin D3;

Panbonis;

Ro 21-5535;

Rocaltrol;

Silkis;

Solbone P;

Soltriol;

Topitriol;

Toptriol
Structure:

Related Targets  (Total: 36)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
A 1 Reference(s)
T34ZK4 Glutathione hydrolase 1 proenzymeGGT1 P19440
A 1 Reference(s)
T41BYM Fibroblast growth factor 23FGF23 Q9GZV9
A 3 Reference(s)
T85JI5 Vitamin D3 receptorVDR P11473
A 11 Reference(s)
T55J1X Radiation-inducible immediate-early gene IEX-1IER3 P46695
A 1 Reference(s)
T38FFJ Potassium voltage-gated channel subfamily H member 1KCNH1 O95259
B 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
B 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
B 1 Reference(s)
T05DRQ Receptor tyrosine-protein kinase erbB-4ERBB4 Q15303
B 1 Reference(s)
T15URL Cathelicidin antimicrobial peptideCAMP P49913
B 2 Reference(s)
T59Y35 Advanced glycosylation end product-specific receptorAGER Q15109
B 2 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
B 1 Reference(s)
T37YKZ Endothelin receptor type BEDNRB P24530
C 1 Reference(s)
T09ICL Transient receptor potential cation channel subfamily V member 6TRPV6 Q9H1D0
C 1 Reference(s)
T56TFE 5'-nucleotidaseNT5E P21589
C 1 Reference(s)
T88UDX Lysine-specific demethylase 6BKDM6B O15054
C 1 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 1 Reference(s)
T75U40 Cytotoxic T-lymphocyte protein 4CTLA4 P16410
C 1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
C 1 Reference(s)
T74GHX OX-2 membrane glycoproteinCD200 P41217
C 1 Reference(s)
T37WQE Kallikrein-5KLK5 Q9Y337
C 1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
C 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
C 1 Reference(s)
T64LXU 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialCYP24A1 Q07973
C 1 Reference(s)
T38TP1 Sodium-dependent phosphate transporter 2SLC20A2 Q08357
C 1 Reference(s)
T68EEP Phospholipase D1PLD1 Q13393
C 1 Reference(s)
T47K8G PodocalyxinPODXL O00592
C 1 Reference(s)
T55JB4 Fibroblast growth factor receptor 1FGFR1 P11362
C 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
C 1 Reference(s)
T06AO4 Membrane cofactor proteinCD46 P15529
C 1 Reference(s)
T82P0Z ReninREN P00797
C 1 Reference(s)
T47WT6 Breast cancer type 1 susceptibility proteinBRCA1 P38398
C 1 Reference(s)
T52I9S 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialCYP27B1 O15528
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens