Target Description

Type Detail
Target ID T59Y35
Protein Name Advanced glycosylation end product-specific receptor
Uniprot ID Q15109
Protein Name Alias Receptor for advanced glycosylation end products
Gene ID 177
Gene Symbol AGER
Gene Alias RAGE
TTD T07400: Clinical Trial target
Pfam PF08205 ; PF13895 ; PF00047
GO
0042802:identical protein binding

0048167:regulation of synaptic plasticity

0038023:signaling receptor activity

0072657:protein localization to membrane

1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

0001540:amyloid-beta binding

0048143:astrocyte activation

2000514:regulation of CD4-positive, alpha-beta T cell activation

1901224:positive regulation of NIK/NF-kappaB signaling

0032693:negative regulation of interleukin-10 production

0098794:postsynapse

0044548:S100 protein binding

0016324:apical plasma membrane

0042104:positive regulation of activated T cell proliferation

1904597:negative regulation of connective tissue replacement involved in inflammatory response wound healing

0001914:regulation of T cell mediated cytotoxicity

0009986:cell surface

0004888:transmembrane signaling receptor activity

0010255:glucose mediated signaling pathway

0032755:positive regulation of interleukin-6 production

0043507:positive regulation of JUN kinase activity

0001666:response to hypoxia

0051092:positive regulation of NF-kappaB transcription factor activity

0007611:learning or memory

0032735:positive regulation of interleukin-12 production

0046330:positive regulation of JNK cascade

0071639:positive regulation of monocyte chemotactic protein-1 production

1900744:regulation of p38MAPK cascade

0050930:induction of positive chemotaxis

0031175:neuron projection development

0090647:modulation of age-related behavioral decline

0034116:positive regulation of heterotypic cell-cell adhesion

0005887:integral component of plasma membrane

0044877:protein-containing complex binding

0050785:advanced glycation end-product receptor activity

0032722:positive regulation of chemokine production

0001934:positive regulation of protein phosphorylation

0005886:plasma membrane

1901222:regulation of NIK/NF-kappaB signaling

0001650:fibrillar center

1904645:response to amyloid-beta

2000439:positive regulation of monocyte extravasation

1900272:negative regulation of long-term synaptic potentiation

2001200:positive regulation of dendritic cell differentiation

0070374:positive regulation of ERK1 and ERK2 cascade

0150104:transport across blood-brain barrier

0006954:inflammatory response

0001774:microglial cell activation

1900745:positive regulation of p38MAPK cascade

0045056:transcytosis

0005044:scavenger receptor activity

0032731:positive regulation of interleukin-1 beta production

0005576:extracellular region

1904646:cellular response to amyloid-beta

0032760:positive regulation of tumor necrosis factor production

0150003:regulation of spontaneous synaptic transmission

0009611:response to wounding

1904472:positive regulation of endothelin production

0050727:regulation of inflammatory response

0030054:cell junction

0051101:regulation of DNA binding

0007166:cell surface receptor signaling pathway

1903523:negative regulation of blood circulation

1900271:regulation of long-term synaptic potentiation

1900453:negative regulation of long-term synaptic depression

0045087:innate immune response

PDB 2M1K ; 4P2Y ; 2MJW ; 4OI8 ; 4YBH ; 2BJP ; 1PWI ; 2LE9 ; 2LMB ; 5D7F ; 2ENS ; 4LP4 ; 4OFV ; 4OI7 ; 2L7U ; 3CJJ ; 4LP5 ; 4XYN ; 3O3U ; 2MOV ; 4OF5 ; 2E5E
Drugbank NA
KEGG hsa:177

Related Compounds  (Total: 4)

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C0347
Name: Pyridoxamine
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C0421
Name: Sulforaphane
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C0828
Name: Picroside Ii
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C1207
Name: Calcitriol


Related Herbs  (Total: 9)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1202 Hu Huang Lian胡黄连 PicrorhizaPicrorhiza kurrooa
H0938 Da Suan大蒜 GarlicAllium sativum
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus