Compound Description
| ID: C0421 | Common name: Sulforaphane |
| IUPAC: 1-isothiocyanato-4-methylsulfinylbutane | CAS: CAS:4478-93-7 |
| Chembl ID: CHEMBL48802 | Pubchem ID: CID:5350 |
| Formula: C6H11NOS2 | TCM-ID: TCMC2114 |
| Smiles: S=C=NCCCCS(=O)C | |
| Alias:
Isothiocyanic acid, 4-(methylsulfinyl)butyl ester;
Sulforaphan; 1-Isothiocyanato-4-(methylsulfinyl)butane; 4-Methylsulfinylbutyl isothiocyanate; BroccoPhane; Detoxophane; Sulforaphane |
Structure:
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Related Targets (Total: 26)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
A | 18 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
A | 2 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
A | 2 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
A | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
A | 2 Reference(s) |
| T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
A | 2 Reference(s) |
| T50C67 | Stimulator of interferon genes protein | STING1 |
Q86WV6 |
A | 1 Reference(s) |
| T77W6N | Thioredoxin reductase 1, cytoplasmic | TXNRD1 |
Q16881 |
A | 1 Reference(s) |
| T75NNQ | NA | MIR140 |
NA |
A | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
A | 1 Reference(s) |
| T93RBO | PDZ and LIM domain protein 1 | PDLIM1 |
O00151 |
B | 1 Reference(s) |
| T36YWU | Kelch-like ECH-associated protein 1 | KEAP1 |
Q14145 |
B | 1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
B | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
C | 2 Reference(s) |
| T18T1M | Tyrosine-protein kinase Mer | MERTK |
Q12866 |
C | 1 Reference(s) |
| T44NOG | Ras GTPase-activating protein nGAP | RASAL2 |
Q9UJF2 |
C | 1 Reference(s) |
| T59Y35 | Advanced glycosylation end product-specific receptor | AGER |
Q15109 |
C | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
C | 1 Reference(s) |
| T53QS9 | Glutamate--cysteine ligase catalytic subunit | GCLC |
P48506 |
C | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T89G4M | Solute carrier family 2, facilitated glucose transporter member 3 | SLC2A3 |
P11169 |
C | 1 Reference(s) |
| T73QS1 | SERTA domain-containing protein 1 | SERTAD1 |
Q9UHV2 |
C | 1 Reference(s) |
| T82VBE | Hormone-sensitive lipase | LIPE |
Q05469 |
C | 1 Reference(s) |
| T40Q1D | Retinal dehydrogenase 1 | ALDH1A1 |
P00352 |
C | 1 Reference(s) |
| T56BNY | NA | MIR135B |
NA |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 7)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0960 | Dang Shen Qing Gao | 党参清膏 | Root of hairy asiabell | Codonopsis pilosula |
| H0466 | Cai Fu Zi | 菜菔子 | Semen raphani | Raphanus sativus |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0958 | Dang Shen | 党参 | Pilose asiabell | Codonopsis pilosula |
| H0126 | Lai Fu Zi | 莱菔子 | Garden radish seed | Raphanus sativus |
| H0125 | Lai Fu | 莱菔 | Garden radish | Raphanus sativus |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
Ckey description of the interaction between compound and target