HIT-result

Target Description

Type	Detail
Target ID	T84G6T
Protein Name	Interleukin-12 subunit beta
Uniprot ID	P29460
Protein Name Alias	IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2
Gene ID	3593
Gene Symbol	IL12B
Gene Alias	NKSF2
TTD	T95385: Successful target
Pfam	PF10420
GO	0050829:defense response to Gram-negative bacterium 0002860:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 0032819:positive regulation of natural killer cell proliferation 0050709:negative regulation of protein secretion 0070743:interleukin-23 complex 0002862:negative regulation of inflammatory response to antigenic stimulus 0042832:defense response to protozoan 0051142:positive regulation of NK T cell proliferation 0005788:endoplasmic reticulum lumen 0005576:extracellular region 0043514:interleukin-12 complex 0045672:positive regulation of osteoclast differentiation 0032733:positive regulation of interleukin-10 production 0032735:positive regulation of interleukin-12 production 0050671:positive regulation of lymphocyte proliferation 0038155:interleukin-23-mediated signaling pathway 0010536:positive regulation of activation of Janus kinase activity 0032725:positive regulation of granulocyte macrophage colony-stimulating factor production 0071346:cellular response to interferon-gamma 0035722:interleukin-12-mediated signaling pathway 0043235:receptor complex 0002323:natural killer cell activation involved in immune response 0048662:negative regulation of smooth muscle cell proliferation 0001916:positive regulation of T cell mediated cytotoxicity 0019233:sensory perception of pain 0032693:negative regulation of interleukin-10 production 1900747:negative regulation of vascular endothelial growth factor signaling pathway 2000330:positive regulation of T-helper 17 cell lineage commitment 0042093:T-helper cell differentiation 0019953:sexual reproduction 0007050:cell cycle arrest 0042509:regulation of tyrosine phosphorylation of STAT protein 0046982:protein heterodimerization activity 0051135:positive regulation of NK T cell activation 0032946:positive regulation of mononuclear cell proliferation 0042531:positive regulation of tyrosine phosphorylation of STAT protein 1903588:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 0045785:positive regulation of cell adhesion 0042104:positive regulation of activated T cell proliferation 0030101:natural killer cell activation 0032740:positive regulation of interleukin-17 production 0043382:positive regulation of memory T cell differentiation 0032816:positive regulation of natural killer cell activation 0002827:positive regulation of T-helper 1 type immune response 0034393:positive regulation of smooth muscle cell apoptotic process 0005143:interleukin-12 receptor binding 0005829:cytosol 0042802:identical protein binding 0071222:cellular response to lipopolysaccharide 0034105:positive regulation of tissue remodeling 0032760:positive regulation of tumor necrosis factor production 0031906:late endosome lumen 0008283:cell population proliferation 0016477:cell migration 0042102:positive regulation of T cell proliferation 0005125:cytokine activity 2000318:positive regulation of T-helper 17 type immune response 0009897:external side of plasma membrane 0032700:negative regulation of interleukin-17 production 0050729:positive regulation of inflammatory response 0010224:response to UV-B 0005615:extracellular space 0019955:cytokine binding 0019221:cytokine-mediated signaling pathway 0051607:defense response to virus 0032729:positive regulation of interferon-gamma production 0004896:cytokine receptor activity 0044877:protein-containing complex binding 0001817:regulation of cytokine production 0042088:T-helper 1 type immune response 1901224:positive regulation of NIK/NF-kappaB signaling 0002230:positive regulation of defense response to virus by host 0042164:interleukin-12 alpha subunit binding
PDB	3HMX ; 1F45 ; 3D87 ; 3D85 ; 5MXA ; 1F42 ; 5MZV ; 6UIB ; 3QWR ; 3DUH ; 5MJ3 ; 5MJ4 ; 5NJD ; 4GRW
Drugbank	DB14762 ; DB05848 ; DB14004 ; DB05679 ; DB02763 ; DB06083 ; DB05459
KEGG	hsa:3593

Type

Detail

Target ID

T84G6T

Protein Name

Interleukin-12 subunit beta

Uniprot ID

P29460

Protein Name Alias

IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2

Gene ID

3593

Gene Symbol

IL12B

Gene Alias

NKSF2

TTD

T95385: Successful target

Pfam

PF10420

0050829:defense response to Gram-negative bacterium

0002860:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

0032819:positive regulation of natural killer cell proliferation

0050709:negative regulation of protein secretion

0070743:interleukin-23 complex

0002862:negative regulation of inflammatory response to antigenic stimulus

0042832:defense response to protozoan

0051142:positive regulation of NK T cell proliferation

0005788:endoplasmic reticulum lumen

0005576:extracellular region

0043514:interleukin-12 complex

0045672:positive regulation of osteoclast differentiation

0032733:positive regulation of interleukin-10 production

0032735:positive regulation of interleukin-12 production

0050671:positive regulation of lymphocyte proliferation

0038155:interleukin-23-mediated signaling pathway

0010536:positive regulation of activation of Janus kinase activity

0032725:positive regulation of granulocyte macrophage colony-stimulating factor production

0071346:cellular response to interferon-gamma

0035722:interleukin-12-mediated signaling pathway

0043235:receptor complex

0002323:natural killer cell activation involved in immune response

0048662:negative regulation of smooth muscle cell proliferation

0001916:positive regulation of T cell mediated cytotoxicity

0019233:sensory perception of pain

0032693:negative regulation of interleukin-10 production

1900747:negative regulation of vascular endothelial growth factor signaling pathway

2000330:positive regulation of T-helper 17 cell lineage commitment

0042093:T-helper cell differentiation

0019953:sexual reproduction

0007050:cell cycle arrest

0042509:regulation of tyrosine phosphorylation of STAT protein

0046982:protein heterodimerization activity

0051135:positive regulation of NK T cell activation

0032946:positive regulation of mononuclear cell proliferation

0042531:positive regulation of tyrosine phosphorylation of STAT protein

1903588:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

0045785:positive regulation of cell adhesion

0042104:positive regulation of activated T cell proliferation

0030101:natural killer cell activation

0032740:positive regulation of interleukin-17 production

0043382:positive regulation of memory T cell differentiation

0032816:positive regulation of natural killer cell activation

0002827:positive regulation of T-helper 1 type immune response

0034393:positive regulation of smooth muscle cell apoptotic process

0005143:interleukin-12 receptor binding

0005829:cytosol

0042802:identical protein binding

0071222:cellular response to lipopolysaccharide

0034105:positive regulation of tissue remodeling

0032760:positive regulation of tumor necrosis factor production

0031906:late endosome lumen

0008283:cell population proliferation

0016477:cell migration

0042102:positive regulation of T cell proliferation

0005125:cytokine activity

2000318:positive regulation of T-helper 17 type immune response

0009897:external side of plasma membrane

0032700:negative regulation of interleukin-17 production

0050729:positive regulation of inflammatory response

0010224:response to UV-B

0005615:extracellular space

0019955:cytokine binding

0019221:cytokine-mediated signaling pathway

0051607:defense response to virus

0032729:positive regulation of interferon-gamma production

0004896:cytokine receptor activity

0044877:protein-containing complex binding

0001817:regulation of cytokine production

0042088:T-helper 1 type immune response

1901224:positive regulation of NIK/NF-kappaB signaling

0002230:positive regulation of defense response to virus by host

0042164:interleukin-12 alpha subunit binding

PDB

3HMX ; 1F45 ; 3D87 ; 3D85 ; 5MXA ; 1F42 ; 5MZV ; 6UIB ; 3QWR ; 3DUH ; 5MJ3 ; 5MJ4 ; 5NJD ; 4GRW

Drugbank

DB14762 ; DB05848 ; DB14004 ; DB05679 ; DB02763 ; DB06083 ; DB05459

KEGG

hsa:3593

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1007	Dou You	豆油	Soybean oil	Glycine max
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0026	Jiang	姜	Soybean paste	Glycine max
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0416	Shan Shen	山参	NA	Panax ginseng
H0194	Ma Bing Lang	马槟榔	Masaikai caper	Capparis masaikai
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0295	Bi Ba	荜茇	Long pepper	Piper longum

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 18)