Target Description

Type Detail
Target ID T84G6T
Protein Name Interleukin-12 subunit beta
Uniprot ID P29460
Protein Name Alias IL-12B;  Cytotoxic lymphocyte maturation factor 40 kDa subunit;  CLMF p40;  IL-12 subunit p40;  NK cell stimulatory factor chain 2;  NKSF2
Gene ID 3593
Gene Symbol IL12B
Gene Alias NKSF2
TTD T95385: Successful target
Pfam PF10420
GO
0050829:defense response to Gram-negative bacterium

0002860:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

0032819:positive regulation of natural killer cell proliferation

0050709:negative regulation of protein secretion

0070743:interleukin-23 complex

0002862:negative regulation of inflammatory response to antigenic stimulus

0042832:defense response to protozoan

0051142:positive regulation of NK T cell proliferation

0005788:endoplasmic reticulum lumen

0005576:extracellular region

0043514:interleukin-12 complex

0045672:positive regulation of osteoclast differentiation

0032733:positive regulation of interleukin-10 production

0032735:positive regulation of interleukin-12 production

0050671:positive regulation of lymphocyte proliferation

0038155:interleukin-23-mediated signaling pathway

0010536:positive regulation of activation of Janus kinase activity

0032725:positive regulation of granulocyte macrophage colony-stimulating factor production

0071346:cellular response to interferon-gamma

0035722:interleukin-12-mediated signaling pathway

0043235:receptor complex

0002323:natural killer cell activation involved in immune response

0048662:negative regulation of smooth muscle cell proliferation

0001916:positive regulation of T cell mediated cytotoxicity

0019233:sensory perception of pain

0032693:negative regulation of interleukin-10 production

1900747:negative regulation of vascular endothelial growth factor signaling pathway

2000330:positive regulation of T-helper 17 cell lineage commitment

0042093:T-helper cell differentiation

0019953:sexual reproduction

0007050:cell cycle arrest

0042509:regulation of tyrosine phosphorylation of STAT protein

0046982:protein heterodimerization activity

0051135:positive regulation of NK T cell activation

0032946:positive regulation of mononuclear cell proliferation

0042531:positive regulation of tyrosine phosphorylation of STAT protein

1903588:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

0045785:positive regulation of cell adhesion

0042104:positive regulation of activated T cell proliferation

0030101:natural killer cell activation

0032740:positive regulation of interleukin-17 production

0043382:positive regulation of memory T cell differentiation

0032816:positive regulation of natural killer cell activation

0002827:positive regulation of T-helper 1 type immune response

0034393:positive regulation of smooth muscle cell apoptotic process

0005143:interleukin-12 receptor binding

0005829:cytosol

0042802:identical protein binding

0071222:cellular response to lipopolysaccharide

0034105:positive regulation of tissue remodeling

0032760:positive regulation of tumor necrosis factor production

0031906:late endosome lumen

0008283:cell population proliferation

0016477:cell migration

0042102:positive regulation of T cell proliferation

0005125:cytokine activity

2000318:positive regulation of T-helper 17 type immune response

0009897:external side of plasma membrane

0032700:negative regulation of interleukin-17 production

0050729:positive regulation of inflammatory response

0010224:response to UV-B

0005615:extracellular space

0019955:cytokine binding

0019221:cytokine-mediated signaling pathway

0051607:defense response to virus

0032729:positive regulation of interferon-gamma production

0004896:cytokine receptor activity

0044877:protein-containing complex binding

0001817:regulation of cytokine production

0042088:T-helper 1 type immune response

1901224:positive regulation of NIK/NF-kappaB signaling

0002230:positive regulation of defense response to virus by host

0042164:interleukin-12 alpha subunit binding

PDB 3HMX ; 1F45 ; 3D87 ; 3D85 ; 5MXA ; 1F42 ; 5MZV ; 6UIB ; 3QWR ; 3DUH ; 5MJ3 ; 5MJ4 ; 5NJD ; 4GRW
Drugbank DB14762 ; DB05848 ; DB14004 ; DB05679 ; DB02763 ; DB06083 ; DB05459
KEGG hsa:3593

Related Compounds  (Total: 2)

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C0315
Name: Piperine
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C0412
Name: Spermidine


Related Herbs  (Total: 18)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0416 Shan Shen山参 NAPanax ginseng
H0194 Ma Bing Lang马槟榔 Masaikai caperCapparis masaikai
H0357 Ren Shen人参 GinsengPanax ginseng
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0295 Bi Ba荜茇 Long pepperPiper longum
H1007 Dou You豆油 Soybean oilGlycine max
H0026 Jiang Soybean pasteGlycine max
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0944 Dan Dou Gu淡豆鼓 NAGlycine max