Compound Description
| ID: C0315 | Common name: Piperine |
| IUPAC: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one | CAS: CAS:94-62-2 |
| Chembl ID: CHEMBL43185 | Pubchem ID: CID:638024 |
| Formula: C17H19NO3 | TCM-ID: TCMC1904 |
| Smiles: C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 | |
| Alias:
Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-;
Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-; Piperidine, 1-piperoyl-, (E,E)-; Piperine; (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one; (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; (E,E)-1-[5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine; (E,E)-5-(3,4-Methylenedioxyphenyl)-2,4-pentadienoylpiperidide; 1-Piperoylpiperidine; Bioperin; Bioperine; NSC 21727; Piperin |
Structure:
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Related Targets (Total: 17)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
A | 1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
A | 1 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
A | 3 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
A | 1 Reference(s) |
| T73EVE | Cyclic AMP-dependent transcription factor ATF-2 | ATF2 |
P15336 |
A | 1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
A | 1 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
A | 2 Reference(s) |
| T95RKQ | Sterol O-acyltransferase 2 | SOAT2 |
O75908 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 2 Reference(s) |
| T36B1Q | Baculoviral IAP repeat-containing protein 5 | BIRC5 |
O15392 |
B | 1 Reference(s) |
| T18YXD | Albumin | ALB |
P02768 |
B | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T84G6T | Interleukin-12 subunit beta | IL12B |
P29460 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 7)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0295 | Bi Ba | 荜茇 | Long pepper | Piper longum |
| H0617 | Qian Cao Teng | 茜草藤 | NA | Rubia cordifolia |
| H1077 | Bai Hu Jiao | 白胡椒 | white pepper | Piper nigrum |
| H1204 | Hu Jiao | 胡椒 | Black pepper | Piper nigrum |
| H1176 | Hei Hu Jiao | 黑胡椒 | Black pepper | Piper nigrum |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
Ckey description of the interaction between compound and target