HIT-result

Target Description

Type	Detail
Target ID	T74RBE
Protein Name	Inositol 1,4,5-trisphosphate receptor type 1
Uniprot ID	Q14643
Protein Name Alias	IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene ID	3708
Gene Symbol	ITPR1
Gene Alias	INSP3R1
TTD	T61227: Research target
Pfam	PF08454 ; PF00520 ; PF08709 ; PF02815 ; PF01365
GO	0030168:platelet activation 0032469:endoplasmic reticulum calcium ion homeostasis 0005789:endoplasmic reticulum membrane 0016021:integral component of membrane 0030667:secretory granule membrane 0019855:calcium channel inhibitor activity 0042045:epithelial fluid transport 0005730:nucleolus 0001666:response to hypoxia 0016020:membrane 0016529:sarcoplasmic reticulum 0030658:transport vesicle membrane 0050849:negative regulation of calcium-mediated signaling 0015278:calcium-release channel activity 0009791:post-embryonic development 0051209:release of sequestered calcium ion into cytosol 0031095:platelet dense tubular network membrane 0006816:calcium ion transport 0031088:platelet dense granule membrane 0098685:Schaffer collateral - CA1 synapse 0050796:regulation of insulin secretion 0005886:plasma membrane 0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1903779:regulation of cardiac conduction 0070679:inositol 1,4,5 trisphosphate binding 0005220:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0030659:cytoplasmic vesicle membrane 0035091:phosphatidylinositol binding 0048471:perinuclear region of cytoplasm 0005783:endoplasmic reticulum 0005637:nuclear inner membrane 0031094:platelet dense tubular network 0005955:calcineurin complex 0005509:calcium ion binding 0015085:calcium ion transmembrane transporter activity 0098695:inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels 0014069:postsynaptic density 0050882:voluntary musculoskeletal movement 0007165:signal transduction 0010506:regulation of autophagy
PDB	NA
Drugbank	DB09462 ; DB00201 ; DB03401 ; DB11590
KEGG	hsa:3708

Type

Detail

Target ID

T74RBE

Protein Name

Inositol 1,4,5-trisphosphate receptor type 1

Uniprot ID

Q14643

Protein Name Alias

IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor

Gene ID

3708

Gene Symbol

ITPR1

Gene Alias

INSP3R1

TTD

T61227: Research target

Pfam

PF08454 ; PF00520 ; PF08709 ; PF02815 ; PF01365

0030168:platelet activation

0032469:endoplasmic reticulum calcium ion homeostasis

0005789:endoplasmic reticulum membrane

0016021:integral component of membrane

0030667:secretory granule membrane

0019855:calcium channel inhibitor activity

0042045:epithelial fluid transport

0005730:nucleolus

0001666:response to hypoxia

0016020:membrane

0016529:sarcoplasmic reticulum

0030658:transport vesicle membrane

0050849:negative regulation of calcium-mediated signaling

0015278:calcium-release channel activity

0009791:post-embryonic development

0051209:release of sequestered calcium ion into cytosol

0031095:platelet dense tubular network membrane

0006816:calcium ion transport

0031088:platelet dense granule membrane

0098685:Schaffer collateral - CA1 synapse

0050796:regulation of insulin secretion

0005886:plasma membrane

0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1903779:regulation of cardiac conduction

0070679:inositol 1,4,5 trisphosphate binding

0005220:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

0030659:cytoplasmic vesicle membrane

0035091:phosphatidylinositol binding

0048471:perinuclear region of cytoplasm

0005783:endoplasmic reticulum

0005637:nuclear inner membrane

0031094:platelet dense tubular network

0005955:calcineurin complex

0005509:calcium ion binding

0015085:calcium ion transmembrane transporter activity

0098695:inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

0014069:postsynaptic density

0050882:voluntary musculoskeletal movement

0007165:signal transduction

0010506:regulation of autophagy

PDB

Drugbank

DB09462 ; DB00201 ; DB03401 ; DB11590

KEGG

hsa:3708

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 20)