Target Description
| Type | Detail |
|---|---|
| Target ID | T42FMQ |
| Protein Name | Mitogen-activated protein kinase kinase kinase 1 |
| Uniprot ID |
Q13233 |
| Protein Name Alias | EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 |
| Gene ID |
4214 |
| Gene Symbol | MAP3K1 |
| Gene Alias | MAPKKK1; MEKK; MEKK1 |
| TTD | T06031: Clinical Trial target |
| Pfam | PF00069 |
| GO |
0106311:protein threonine kinase activity
0019901:protein kinase binding 0071260:cellular response to mechanical stimulus 0004674:protein serine/threonine kinase activity 0002755:MyD88-dependent toll-like receptor signaling pathway 0005829:cytosol 0038095:Fc-epsilon receptor signaling pathway 0004709:MAP kinase kinase kinase activity 0005524:ATP binding 0008270:zinc ion binding 0106310:protein serine kinase activity 0006468:protein phosphorylation 0004672:protein kinase activity |
| PDB | 6WHB |
| Drugbank | DB12010 ; DB11967 ; DB06061 |
| KEGG | hsa:4214 |
Related Herbs (Total: 64)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0104 | Bai Zhu | 白术 | Largehead atractylodes | Atractylodes macrocephala |
| H0256 | Ming Dang Shen | 明党参 | Medicinal changium | Changium smyrnioides |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0868 | Chuan Du Huo | 川独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1170 | He Zi | 诃子 | Medicine terminalia | Terminalia chebula |
| H0342 | Qing Hao | 青蒿 | sweet wormwood | Artemisia carvifolia |
| H0656 | Xiao Bo Gen | 小檗根 | Barberry root | Berberis julianae |
| H0344 | Qing Guo | 青果 | Olive | Canarium album |
| H0772 | Yue Ji Hua | 月季花 | Chinese rose | Rosa chinensis |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H0974 | Di Jin Cao | 地锦草 | Humifuse euphorbia | Euphorbia humifusa |
| H0068 | Jin Ying Zi Rou | 金樱子肉 | Cherokee rose seed | Rosa laevigata |
| H0069 | Jin Ying Zi Ti Qu Ye | 金樱子提取液 | Cherokee rose seed | Rosa laevigata |
| H0163 | Long Dan Jin Gao | 龙胆浸膏 | Rough gentian | Gentiana scabra |
| H1025 | Fan Bai Cao | 翻白草 | Discolor cinquefoil | Potentilla discolor |
| H1137 | Gui Yuan | 桂圆 | NA | Dimocarpus longan |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H1091 | Gao Li Shen | 高丽参 | Korea ginseng | Radix ginseng korea |
| H1097 | Gong Ding Xiang | 公丁香 | NA | Syzygium aromaticum |
| H0975 | Di Mian Cao | 地绵草 | NA | Euphorbia humifusa |
| H0343 | Qing Hao Zi | 青蒿子 | sweet wormwood | Artemisia carvifolia |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0759 | Yu Gan Zi | 余甘子 | Emblic leafflower fruit | Fructus phyllanthi |
| H0345 | Qing Guo Tan | 青果炭 | white olive | Canarium album |
| H0959 | Dang Shen Lu Tou | 党参芦头 | Rhizome of pilose asiabell | Rhizoma codonopsis pilosulae |
| H0267 | Mu Ding Xiang | 母丁香 | Clove fruit | Fructus caryophylli |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1035 | Bai Fu Ling | 白茯苓 | white indian bread | Wolfiporia cocos |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0066 | Jin Ying Gen | 金樱根 | root of cherokee rose | Radix rosae laevigatae |
| H0461 | Shi Jun Zi Ren | 使君子仁 | NA | Combretum indicum |
| H0070 | Jing Da Ji | 京大戟 | Peking euphorbia root | Radix euphorbiae pekinensis |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0288 | Niu Bang Cao | 牛蒡草 | greater burdock | Arctium lappa |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0934 | Da Ji | 大戟 | Peking spurge root | Radix euphorbiae pekinensis |
| H0784 | Chi Shao | 赤芍 | Red peony root | Paeonia obovata |
| H0990 | Ding Xiang | 丁香 | Clove tree | Syzygium aromaticum |
| H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
| H0162 | Long Dan | 龙胆 | Rough gentian | Gentiana scabra |
| H1056 | Fu Pen Zi | 覆盆子 | Red-and-Yellow garden raspberry | Rubus idaeus |
| H1082 | Gan Lan | 橄榄 | Cabbage | Canarium album |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0634 | Xian He Cao | 仙鹤草 | Japanese argimonia | Agrimonia pilosa var. japonica |
| H0252 | Mian Da Ji | 绵大戟 | NA | Euphorbia pekinensis |
| H1171 | He Zi Rou | 诃子肉 | Medicine terminalia | Terminalia chebula |
| H0128 | Lao Guan Cao | 老鹳草 | Wilford cranesbill | Geranium wilfordii |
| H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0429 | Shao Yao | 芍药 | Red peony root | Paeonia obovata |
| H0635 | Xian He Cao Jin Gao Fen | 仙鹤草浸膏粉 | Japanese argimonia | Agrimonia pilosa var. japonica |
| H0547 | Cang Qing Guo | 藏青果 | Myrobalan | Terminalia chebula |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0067 | Jin Ying Zi | 金樱子 | Cherokee rose seed | Rosa laevigata |
| H1009 | Du Huo | 独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H1130 | Guang Zao | 广枣 | fruit of axillary choerospondias | Fructus choerospondiatis |