Target Description

Type Detail
Target ID T26QPN
Protein Name Maternal embryonic leucine zipper kinase
Uniprot ID Q14680
Protein Name Alias hMELK;  EC 2.7.11.1;  Protein kinase Eg3;  pEg3 kinase;  Protein kinase PK38;  hPK38;  Tyrosine-protein kinase MELK;  EC 2.7.10.2
Gene ID 9833
Gene Symbol MELK
Gene Alias KIAA0175
TTD T61518: Clinical Trial target
Pfam PF00069 ; PF02149
GO
0005634:nucleus

0046777:protein autophosphorylation

0035556:intracellular signal transduction

0005938:cell cortex

0106310:protein serine kinase activity

0004674:protein serine/threonine kinase activity

0008631:intrinsic apoptotic signaling pathway in response to oxidative stress

0106311:protein threonine kinase activity

0006915:apoptotic process

0005737:cytoplasm

0005509:calcium ion binding

0005524:ATP binding

0005886:plasma membrane

0016020:membrane

0030097:hemopoiesis

0004715:non-membrane spanning protein tyrosine kinase activity

0043065:positive regulation of apoptotic process

0006468:protein phosphorylation

0004714:transmembrane receptor protein tyrosine kinase activity

0061351:neural precursor cell proliferation

0000086:G2/M transition of mitotic cell cycle

0008283:cell population proliferation

0008289:lipid binding

PDB 5TWU ; 4UMQ ; 4UMP ; 5IH8 ; 4BKY ; 5IHA ; 4D2P ; 5TWZ ; 5MAI ; 5TVT ; 6VXR ; 5TX3 ; 5M5A ; 5TWY ; 5MAH ; 4UMT ; 5MAF ; 5IHC ; 5K00 ; 4BL1 ; 5IH9 ; 4IXP ; 6GVX ; 4D2V ; 5MAG ; 4UMU ; 4UMR ; 4D2W ; 4BKZ ; 5TWL ; 4D2T
Drugbank DB12010
KEGG hsa:9833

Related Compounds  (Total: 1)

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C0281
Name: Paclitaxel


Related Herbs  (Total: 6)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum