HIT-result

Target Description

Type	Detail
Target ID	T17FIA
Protein Name	Angiotensinogen
Uniprot ID	P01019
Protein Name Alias	Serpin A8
Gene ID	183
Gene Symbol	AGT
Gene Alias	SERPINA8
TTD	T64485: Research target
Pfam	PF00079
GO	0070062:extracellular exosome 2000379:positive regulation of reactive oxygen species metabolic process 0001558:regulation of cell growth 0090190:positive regulation of branching involved in ureteric bud morphogenesis 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0045742:positive regulation of epidermal growth factor receptor signaling pathway 0010629:negative regulation of gene expression 1902632:positive regulation of membrane hyperpolarization 0005615:extracellular space 0033864:positive regulation of NAD(P)H oxidase activity 0010613:positive regulation of cardiac muscle hypertrophy 0048146:positive regulation of fibroblast proliferation 0031703:type 2 angiotensin receptor binding 2001238:positive regulation of extrinsic apoptotic signaling pathway 1903598:positive regulation of gap junction assembly 0002034:maintenance of blood vessel diameter homeostasis by renin-angiotensin 0001974:blood vessel remodeling 2000650:negative regulation of sodium ion transmembrane transporter activity 0007186:G protein-coupled receptor signaling pathway 0072562:blood microparticle 0035813:regulation of renal sodium excretion 0008217:regulation of blood pressure 0005829:cytosol 0010951:negative regulation of endopeptidase activity 0001819:positive regulation of cytokine production 0014873:response to muscle activity involved in regulation of muscle adaptation 0051387:negative regulation of neurotrophin TRK receptor signaling pathway 1901201:regulation of extracellular matrix assembly 0038166:angiotensin-activated signaling pathway 0005576:extracellular region 0008083:growth factor activity 0062023:collagen-containing extracellular matrix 0002018:renin-angiotensin regulation of aldosterone production 0048018:receptor ligand activity 0007267:cell-cell signaling 1903779:regulation of cardiac conduction 0031702:type 1 angiotensin receptor binding 0034374:low-density lipoprotein particle remodeling 0061098:positive regulation of protein tyrosine kinase activity 0010744:positive regulation of macrophage derived foam cell differentiation 0001822:kidney development 0043407:negative regulation of MAP kinase activity 0019229:regulation of vasoconstriction 0045893:positive regulation of transcription, DNA-templated 0042310:vasoconstriction 0010873:positive regulation of cholesterol esterification 0007199:G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger 0002016:regulation of blood volume by renin-angiotensin 0003014:renal system process 0002019:regulation of renal output by angiotensin 0050729:positive regulation of inflammatory response 0010536:positive regulation of activation of Janus kinase activity 0007263:nitric oxide mediated signal transduction 0019222:regulation of metabolic process 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0004867:serine-type endopeptidase inhibitor activity 0032270:positive regulation of cellular protein metabolic process 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0005179:hormone activity 0042127:regulation of cell population proliferation 0051092:positive regulation of NF-kappaB transcription factor activity 0000187:activation of MAPK activity 0016176:superoxide-generating NADPH oxidase activator activity 0017080:sodium channel regulator activity 0010595:positive regulation of endothelial cell migration
PDB	2JP8 ; 4AA1 ; 2WXW ; 3WOR ; 2X0B ; 5M3Y ; 3WOO ; 5E2Q ; 4FYS ; 5XJM ; 3CK0 ; 1N9V ; 5M3X ; 1N9U ; 4APH ; 6JOD ; 6I3F ; 6OS0 ; 6I3I ; 7C6A
Drugbank	DB09130 ; DB12548 ; DB01593 ; DB14487
KEGG	NA

Type

Detail

Target ID

T17FIA

Protein Name

Angiotensinogen

Uniprot ID

P01019

Protein Name Alias

Serpin A8

Gene ID

183

Gene Symbol

AGT

Gene Alias

SERPINA8

TTD

T64485: Research target

Pfam

PF00079

0070062:extracellular exosome

2000379:positive regulation of reactive oxygen species metabolic process

0001558:regulation of cell growth

0090190:positive regulation of branching involved in ureteric bud morphogenesis

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0045742:positive regulation of epidermal growth factor receptor signaling pathway

0010629:negative regulation of gene expression

1902632:positive regulation of membrane hyperpolarization

0005615:extracellular space

0033864:positive regulation of NAD(P)H oxidase activity

0010613:positive regulation of cardiac muscle hypertrophy

0048146:positive regulation of fibroblast proliferation

0031703:type 2 angiotensin receptor binding

2001238:positive regulation of extrinsic apoptotic signaling pathway

1903598:positive regulation of gap junction assembly

0002034:maintenance of blood vessel diameter homeostasis by renin-angiotensin

0001974:blood vessel remodeling

2000650:negative regulation of sodium ion transmembrane transporter activity

0007186:G protein-coupled receptor signaling pathway

0072562:blood microparticle

0035813:regulation of renal sodium excretion

0008217:regulation of blood pressure

0005829:cytosol

0010951:negative regulation of endopeptidase activity

0001819:positive regulation of cytokine production

0014873:response to muscle activity involved in regulation of muscle adaptation

0051387:negative regulation of neurotrophin TRK receptor signaling pathway

1901201:regulation of extracellular matrix assembly

0038166:angiotensin-activated signaling pathway

0005576:extracellular region

0008083:growth factor activity

0062023:collagen-containing extracellular matrix

0002018:renin-angiotensin regulation of aldosterone production

0048018:receptor ligand activity

0007267:cell-cell signaling

1903779:regulation of cardiac conduction

0031702:type 1 angiotensin receptor binding

0034374:low-density lipoprotein particle remodeling

0061098:positive regulation of protein tyrosine kinase activity

0010744:positive regulation of macrophage derived foam cell differentiation

0001822:kidney development

0043407:negative regulation of MAP kinase activity

0019229:regulation of vasoconstriction

0045893:positive regulation of transcription, DNA-templated

0042310:vasoconstriction

0010873:positive regulation of cholesterol esterification

0007199:G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

0002016:regulation of blood volume by renin-angiotensin

0003014:renal system process

0002019:regulation of renal output by angiotensin

0050729:positive regulation of inflammatory response

0010536:positive regulation of activation of Janus kinase activity

0007263:nitric oxide mediated signal transduction

0019222:regulation of metabolic process

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0004867:serine-type endopeptidase inhibitor activity

0032270:positive regulation of cellular protein metabolic process

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0005179:hormone activity

0042127:regulation of cell population proliferation

0051092:positive regulation of NF-kappaB transcription factor activity

0000187:activation of MAPK activity

0016176:superoxide-generating NADPH oxidase activator activity

0017080:sodium channel regulator activity

0010595:positive regulation of endothelial cell migration

PDB

2JP8 ; 4AA1 ; 2WXW ; 3WOR ; 2X0B ; 5M3Y ; 3WOO ; 5E2Q ; 4FYS ; 5XJM ; 3CK0 ; 1N9V ; 5M3X ; 1N9U ; 4APH ; 6JOD ; 6I3F ; 6OS0 ; 6I3I ; 7C6A

Drugbank

DB09130 ; DB12548 ; DB01593 ; DB14487

KEGG

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0077	Jiu	酒	Ethanol	Vinum
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0244	Mi La	蜜蜡	Bee wax	Apis cerana
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0233	Mao Liang Mian Zhen	毛两面针	NA	Zanthoxylum nitidum
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H0961	Dang Yao	当药	Chinese swertia	Swertia chinensis
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0903	Ci Cai	荠菜	Shepherdspurse	Capsella bursa-pastoris
H0549	Tian Zhu Huang	天竺黄	Chinese schinzostachyum tabasheer	Concretio silicea bambusae
H1040	Feng Mi	蜂蜜	Honey	Apis cerana
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0967	Di Er Cao	地耳草	Japanese stJohn’swort	Hypericum japonicum
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H1163	He Bao Cao	荷包草	NA	Lamprocapnos spectabilis
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum

Target Description

Related Compounds (Total: 9)

Related Herbs (Total: 30)