HIT-result

Target Description

Type	Detail
Target ID	T02HZD
Protein Name	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Uniprot ID	Q6NYC1
Protein Name Alias	EC 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR
Gene ID	23210
Gene Symbol	JMJD6
Gene Alias	KIAA0585; PSR; PTDSR
TTD	NA
Pfam	PF02373
GO	0042802:identical protein binding 0005634:nucleus 0140537:transcription regulator activator activity 0038023:signaling receptor activity 0008380:RNA splicing 0005829:cytosol 0035515:oxidative RNA demethylase activity 0043654:recognition of apoptotic cell 0005506:iron ion binding 0032451:demethylase activity 0030324:lung development 0070815:peptidyl-lysine 5-dioxygenase activity 0033749:histone demethylase activity (H4-R3 specific) 0018395:peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine 0007507:heart development 0070079:histone H4-R3 demethylation 0006397:mRNA processing 0035513:oxidative RNA demethylation 0033077:T cell differentiation in thymus 0070078:histone H3-R2 demethylation 0005886:plasma membrane 0001822:kidney development 0005730:nucleolus 1990904:ribonucleoprotein complex 0003723:RNA binding 0048821:erythrocyte development 0045893:positive regulation of transcription, DNA-templated 0033746:histone demethylase activity (H3-R2 specific) 0032452:histone demethylase activity 0048024:regulation of mRNA splicing, via spliceosome 0005737:cytoplasm 0042116:macrophage activation 0002040:sprouting angiogenesis 0005654:nucleoplasm 0060041:retina development in camera-type eye 0007166:cell surface receptor signaling pathway 0106140:P-TEFb complex binding 0006482:protein demethylation 0045944:positive regulation of transcription by RNA polymerase II 0003727:single-stranded RNA binding 0051260:protein homooligomerization
PDB	3K2O ; 6MEV ; 6GDY ; 3LD8 ; 6BNH ; 3LDB
Drugbank	NA
KEGG	hsa:23210

Type

Detail

Target ID

T02HZD

Protein Name

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Uniprot ID

Q6NYC1

Protein Name Alias

EC 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR

Gene ID

23210

Gene Symbol

JMJD6

Gene Alias

KIAA0585; PSR; PTDSR

TTD

Pfam

PF02373

0042802:identical protein binding

0005634:nucleus

0140537:transcription regulator activator activity

0038023:signaling receptor activity

0008380:RNA splicing

0005829:cytosol

0035515:oxidative RNA demethylase activity

0043654:recognition of apoptotic cell

0005506:iron ion binding

0032451:demethylase activity

0030324:lung development

0070815:peptidyl-lysine 5-dioxygenase activity

0033749:histone demethylase activity (H4-R3 specific)

0018395:peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine

0007507:heart development

0070079:histone H4-R3 demethylation

0006397:mRNA processing

0035513:oxidative RNA demethylation

0033077:T cell differentiation in thymus

0070078:histone H3-R2 demethylation

0005886:plasma membrane

0001822:kidney development

0005730:nucleolus

1990904:ribonucleoprotein complex

0003723:RNA binding

0048821:erythrocyte development

0045893:positive regulation of transcription, DNA-templated

0033746:histone demethylase activity (H3-R2 specific)

0032452:histone demethylase activity

0048024:regulation of mRNA splicing, via spliceosome

0005737:cytoplasm

0042116:macrophage activation

0002040:sprouting angiogenesis

0005654:nucleoplasm

0060041:retina development in camera-type eye

0007166:cell surface receptor signaling pathway

0106140:P-TEFb complex binding

0006482:protein demethylation

0045944:positive regulation of transcription by RNA polymerase II

0003727:single-stranded RNA binding

0051260:protein homooligomerization

PDB

3K2O ; 6MEV ; 6GDY ; 3LD8 ; 6BNH ; 3LDB

Drugbank

KEGG

hsa:23210

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H0416	Shan Shen	山参	NA	Panax ginseng
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0077	Jiu	酒	Ethanol	Vinum
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 17)