HIT-result

ID: C0152	Common name: Isoliquiritigenin
IUPAC: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one	CAS: CAS:961-29-5
Chembl ID: CHEMBL129795	Pubchem ID: CID:638278
Formula: C15H12O4	TCM-ID: TCMC1399
Smiles: C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
Alias: 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (E)-; Chalcone, 2',4,4'-trihydroxy-; (2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 2',4,4'-Trihydroxychalcone; GU 17; Isoliquiritigen; Isoliquiritigenin	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T29MD1	Mitogen-activated protein kinase 8	MAPK8	P45983	A	1 Reference(s)
T92HNO	High mobility group protein B1	HMGB1	P09429	A	1 Reference(s)
T32JN2	Beta-glucuronidase	GUSB	P08236	A	1 Reference(s)
T16MRU	NACHT, LRR and PYD domains-containing protein 3	NLRP3	Q96P20	A	1 Reference(s)
T75H3W	Cyclin-dependent kinase 2	CDK2	P24941	A	1 Reference(s)
T24U57	E-selectin	SELE	P16581	B	1 Reference(s)
T59IKQ	Vascular cell adhesion protein 1	VCAM1	P19320	B	1 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	B	1 Reference(s)
T65S3S	Tyrosine-protein kinase JAK2	JAK2	O60674	B	1 Reference(s)
T13KGH	Tyrosinase	TYR	P14679	B	1 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	B	1 Reference(s)
T55IIP	CDGSH iron-sulfur domain-containing protein 1	CISD1	Q9NZ45	C	1 Reference(s)
T54SZZ	Endoplasmic reticulum chaperone BiP	HSPA5	P11021	C	1 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	C	1 Reference(s)
T97XMW	NA	MIR374A	NA	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0803	Zhi Huang Jing	制黄精	Prepared rhizome of fragrant solomonseal	Polygonatum sibiricum
H0190	Lv Dou	绿豆	Common sainfoin	Onobrychis viciifolia
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H1239	Huang Jing Gan Jin Gao	黄精干浸膏	NA	Polygonatum sibiricum
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H0081	Jiu Huang Jing	酒黄精	Siberian solomonseal	Polygonatum sibiricum
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1238	Huang Jing	黄精	Siberian solomonseal	Polygonatum sibiricum
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H1007	Dou You	豆油	Soybean oil	Glycine max
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Compound Description

Related Targets (Total: 15)

Related Herbs (Total: 32)