HIT-result

Type	Detail
Target ID	T01S8U
Protein Name	Metalloproteinase inhibitor 2
Uniprot ID	P16035
Protein Name Alias	CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
Gene ID	7077
Gene Symbol	TIMP2
Gene Alias	NA
TTD	NA
Pfam	PF00965
GO	0005178:integrin binding 0007417:central nervous system development 0043410:positive regulation of MAPK cascade 0031012:extracellular matrix 0005615:extracellular space 0042493:response to drug 0045762:positive regulation of adenylate cyclase activity 0045666:positive regulation of neuron differentiation 0046580:negative regulation of Ras protein signal transduction 0043025:neuronal cell body 0009986:cell surface 0030426:growth cone 0010951:negative regulation of endopeptidase activity 0009725:response to hormone 0005576:extracellular region 0062023:collagen-containing extracellular matrix 0032487:regulation of Rap protein signal transduction 1904813:ficolin-1-rich granule lumen 0034097:response to cytokine 0022617:extracellular matrix disassembly 1904724:tertiary granule lumen 0008270:zinc ion binding 0043312:neutrophil degranulation 0035580:specific granule lumen 0002020:protease binding 0045930:negative regulation of mitotic cell cycle 0030414:peptidase inhibitor activity 1905049:negative regulation of metallopeptidase activity 0010033:response to organic substance 0008285:negative regulation of cell population proliferation 0007568:aging 0051045:negative regulation of membrane protein ectodomain proteolysis 0008191:metalloendopeptidase inhibitor activity
PDB	4ILW ; 2TMP ; 1BR9 ; 1GXD
Drugbank	NA
KEGG	hsa:7077

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0891	Chuan Xin Lian Ye	穿心莲叶	Powder of green chiretta leaves	Andrographis herba
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0077	Jiu	酒	Ethanol	Vinum
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0284	Nan She Teng	南蛇藤	Oriental bittersweet	Celastrus orbiculatus
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0130	Lei Gong Teng	雷公藤	Common threewingnut	Tripterygium wilfordii
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum
H0527	Tao	桃	Peach	Prunus persica
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis

Target Description

Related Compounds (Total: 6)

Related Herbs (Total: 37)