Compound Description
| ID: C0267 | Common name: Oroxylin A |
| IUPAC: 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | CAS: CAS:480-11-5 |
| Chembl ID: CHEMBL183513 | Pubchem ID: CID:5320315 |
| Formula: C16H12O5 | TCM-ID: TCMC1798 |
| Smiles: COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O | |
| Alias:
Flavone, 5,7-dihydroxy-6-methoxy-;
Oroxylin; 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-6-methoxyflavone; 6-Methoxybaicalein; Baicalein 6-methyl ether; Oroxylin A |
Structure:
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Related Targets (Total: 15)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T40MJF | Gamma-aminobutyric acid receptor subunit gamma-1 | GABRG1 |
Q8N1C3 |
A | 1 Reference(s) |
| T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
A | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
B | 1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
B | 1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
B | 1 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
B | 1 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
B | 1 Reference(s) |
| T46NT6 | Cyclin-dependent kinase 7 | CDK7 |
P50613 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
B | 1 Reference(s) |
| T83Y39 | Fructose-2,6-bisphosphatase TIGAR | TIGAR |
Q9NQ88 |
C | 1 Reference(s) |
| T01S8U | Metalloproteinase inhibitor 2 | TIMP2 |
P16035 |
C | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 2 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 15)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0531 | Tao Zhi | 桃枝 | Peach juvenile branch | Prunus persica |
| H0527 | Tao | 桃 | Peach | Prunus persica |
| H0891 | Chuan Xin Lian Ye | 穿心莲叶 | Powder of green chiretta leaves | Andrographis herba |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0529 | Tao Ren | 桃仁 | Peach kernel | Prunus persica |
| H0530 | Tao Ren Shuang | 桃仁霜 | Peach kernel | Prunus persica |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
Ckey description of the interaction between compound and target