HIT-result

Type	Detail
Target ID	T97TLX
Protein Name	Activin receptor type-1
Uniprot ID	Q04771
Protein Name Alias	EC 2.7.11.30; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
Gene ID	90
Gene Symbol	ACVR1
Gene Alias	ACVRLK2
TTD	T12091: Clinical Trial target
Pfam	PF07714 ; PF01064 ; PF08515
GO	0061312:BMP signaling pathway involved in heart development 0007179:transforming growth factor beta receptor signaling pathway 0005524:ATP binding 0002526:acute inflammatory response 0030501:positive regulation of bone mineralization 0061445:endocardial cushion cell fate commitment 0045296:cadherin binding 0001701:in utero embryonic development 0060412:ventricular septum morphogenesis 0045177:apical part of cell 1990782:protein tyrosine kinase binding 0046332:SMAD binding 0009953:dorsal/ventral pattern formation 0045944:positive regulation of transcription by RNA polymerase II 0001702:gastrulation with mouth forming second 0003203:endocardial cushion morphogenesis 0003274:endocardial cushion fusion 0001525:angiogenesis 0001569:branching involved in blood vessel morphogenesis 2000017:positive regulation of determination of dorsal identity 0071363:cellular response to growth factor stimulus 0030509:BMP signaling pathway 0048179:activin receptor complex 0005025:transforming growth factor beta receptor activity, type I 0001707:mesoderm formation 0018107:peptidyl-threonine phosphorylation 0004675:transmembrane receptor protein serine/threonine kinase activity 2001237:negative regulation of extrinsic apoptotic signaling pathway 0006468:protein phosphorylation 0030278:regulation of ossification 0005886:plasma membrane 1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 0007507:heart development 0009968:negative regulation of signal transduction 0042803:protein homodimerization activity 0045669:positive regulation of osteoblast differentiation 0051145:smooth muscle cell differentiation 0005887:integral component of plasma membrane 0071773:cellular response to BMP stimulus 0010862:positive regulation of pathway-restricted SMAD protein phosphorylation 0017046:peptide hormone binding 0045893:positive regulation of transcription, DNA-templated 0043235:receptor complex 0003289:atrial septum primum morphogenesis 0003181:atrioventricular valve morphogenesis 0050431:transforming growth factor beta binding 0060037:pharyngeal system development 0032924:activin receptor signaling pathway 0000082:G1/S transition of mitotic cell cycle 0048185:activin binding 0016361:activin receptor activity, type I 0004674:protein serine/threonine kinase activity 0060923:cardiac muscle cell fate commitment 0032926:negative regulation of activin receptor signaling pathway 0007281:germ cell development 0001755:neural crest cell migration 0060389:pathway-restricted SMAD protein phosphorylation 0030335:positive regulation of cell migration 0070724:BMP receptor complex 0046872:metal ion binding 0007368:determination of left/right symmetry 0003143:embryonic heart tube morphogenesis 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0003183:mitral valve morphogenesis 0004672:protein kinase activity
PDB	3MTF ; 4BGG ; 6T6D ; 6GI6 ; 6I1S ; 6JUX ; 5OY6 ; 6EIX ; 4C02 ; 5OXG ; 6Z36 ; 6GIP ; 6SZM ; 3H9R ; 3Q4U ; 6SRH ; 6GIN ; 6ZGC ; 3OOM ; 4DYM ; 6T8N ; 6TN8 ; 7A21 ; 6ACR
Drugbank	DB08597 ; DB00171 ; DB12010
KEGG	hsa:90

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Name: Melatonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens