Target Description

Type Detail
Target ID T35XJB
Protein Name Period circadian protein homolog 1
Uniprot ID O15534
Protein Name Alias hPER1;  Circadian clock protein PERIOD 1;  Circadian pacemaker protein Rigui
Gene ID 5187
Gene Symbol PER1
Gene Alias KIAA0482;  PER;  RIGUI
TTD T65236: Successful target
Pfam PF08447 ; PF12114
GO
0005634:nucleus

0019900:kinase binding

0007623:circadian rhythm

0005829:cytosol

2000323:negative regulation of glucocorticoid receptor signaling pathway

0031625:ubiquitin protein ligase binding

0046329:negative regulation of JNK cascade

0051591:response to cAMP

0097167:circadian regulation of translation

0042752:regulation of circadian rhythm

0045892:negative regulation of transcription, DNA-templated

0000976:transcription regulatory region sequence-specific DNA binding

0032922:circadian regulation of gene expression

0005654:nucleoplasm

1900744:regulation of p38MAPK cascade

0045944:positive regulation of transcription by RNA polymerase II

0043967:histone H4 acetylation

0010608:posttranscriptional regulation of gene expression

0070932:histone H3 deacetylation

0000122:negative regulation of transcription by RNA polymerase II

0009649:entrainment of circadian clock

0001222:transcription corepressor binding

0070888:E-box binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0042634:regulation of hair cycle

1900015:regulation of cytokine production involved in inflammatory response

0043153:entrainment of circadian clock by photoperiod

0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling

0043966:histone H3 acetylation

0002028:regulation of sodium ion transport

0031490:chromatin DNA binding

0005737:cytoplasm

PDB 1UL6
Drugbank NA
KEGG hsa:5187

Related Compounds  (Total: 3)

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C0210
Name: Melatonin
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C0255
Name: Norepinephrine
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C1104
Name: adrenaline


Related Herbs  (Total: 14)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0488 Shui Niu Jiao Gan Jin Gao水牛角干浸膏 Buffalo hornBubalus bubalis
H0732 Ye Mu Dan野牡丹 Common melastomaMelastoma candidum
H0489 Shui Niu Jiao Nong Suo Fen水牛角浓缩粉 Buffalo hornBubalus bubalis
H0487 Shui Niu Jiao水牛角 Buffalo hornBubalus bubalis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0643 Xiang Jiao橡胶 RubberMusa paradisiaca var. sapientum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0293 Niu Jiao Tan牛角炭 Buffalo hornBubalus bubalis
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0292 Niu Jiao Jian Fen牛角尖粉 Buffalo hornBubalus bubalis
H0291 Niu Jiao Fen牛角粉 Buffalo hornBubalus bubalis
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin