Target Description

Type Detail
Target ID T12W63
Protein Name Rho-associated protein kinase 2
Uniprot ID O75116
Protein Name Alias EC 2.7.11.1;  Rho kinase 2;  Rho-associated, coiled-coil-containing protein kinase 2;  Rho-associated, coiled-coil-containing protein kinase II;  ROCK-II;  p164 ROCK-2
Gene ID 9475
Gene Symbol ROCK2
Gene Alias KIAA0619
TTD T06093: Clinical Trial target
Pfam PF00069 ; PF08912
GO
1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

0106310:protein serine kinase activity

0002931:response to ischemia

0004674:protein serine/threonine kinase activity

0061157:mRNA destabilization

0018105:peptidyl-serine phosphorylation

0032956:regulation of actin cytoskeleton organization

0045019:negative regulation of nitric oxide biosynthetic process

0010825:positive regulation of centrosome duplication

0010629:negative regulation of gene expression

1903347:negative regulation of bicellular tight junction assembly

0031267:small GTPase binding

0010613:positive regulation of cardiac muscle hypertrophy

0051298:centrosome duplication

0007186:G protein-coupled receptor signaling pathway

0045616:regulation of keratinocyte differentiation

0031644:regulation of nervous system process

2000114:regulation of establishment of cell polarity

0005829:cytosol

0051496:positive regulation of stress fiber assembly

1905205:positive regulation of connective tissue replacement

1903140:regulation of establishment of endothelial barrier

1901888:regulation of cell junction assembly

0071559:response to transforming growth factor beta

0005737:cytoplasm

0006939:smooth muscle contraction

0010628:positive regulation of gene expression

0005524:ATP binding

1902966:positive regulation of protein localization to early endosome

0001934:positive regulation of protein phosphorylation

0018107:peptidyl-threonine phosphorylation

0006468:protein phosphorylation

0030866:cortical actin cytoskeleton organization

0046872:metal ion binding

0007249:I-kappaB kinase/NF-kappaB signaling

0070168:negative regulation of biomineral tissue development

1900037:regulation of cellular response to hypoxia

0005634:nucleus

0043410:positive regulation of MAPK cascade

0090271:positive regulation of fibroblast growth factor production

0051492:regulation of stress fiber assembly

0106311:protein threonine kinase activity

0110061:regulation of angiotensin-activated signaling pathway

0042752:regulation of circadian rhythm

1990776:response to angiotensin

0050321:tau-protein kinase activity

0039694:viral RNA genome replication

0032723:positive regulation of connective tissue growth factor production

0005198:structural molecule activity

0150033:negative regulation of protein localization to lysosome

0048013:ephrin receptor signaling pathway

0005856:cytoskeleton

1902993:positive regulation of amyloid precursor protein catabolic process

0048511:rhythmic process

0003723:RNA binding

0072659:protein localization to plasma membrane

1905145:cellular response to acetylcholine

0000281:mitotic cytokinesis

0016525:negative regulation of angiogenesis

0030335:positive regulation of cell migration

0031032:actomyosin structure organization

0010595:positive regulation of endothelial cell migration

0005813:centrosome

0035509:negative regulation of myosin-light-chain-phosphatase activity

0048010:vascular endothelial growth factor receptor signaling pathway

0036464:cytoplasmic ribonucleoprotein granule

0005886:plasma membrane

0048598:embryonic morphogenesis

0030155:regulation of cell adhesion

0003180:aortic valve morphogenesis

0048156:tau protein binding

0051893:regulation of focal adhesion assembly

0072518:Rho-dependent protein serine/threonine kinase activity

0097746:blood vessel diameter maintenance

0071394:cellular response to testosterone stimulus

2000145:regulation of cell motility

1902004:positive regulation of amyloid-beta formation

0051246:regulation of protein metabolic process

0007266:Rho protein signal transduction

PDB 7JOV ; 6P5P ; 5U7R ; 5U7Q ; 4WOT ; 6P5M ; 7JNT ; 4L6Q ; 6ED6
Drugbank DB13931 ; DB12010 ; DB08756 ; DB08162 ; DB13165
KEGG hsa:9475

Related Compounds  (Total: 1)

Go to browser
C0210
Name: Melatonin


Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens