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Target Description
Type
Detail
Target ID
T12W63
Protein Name
Rho-associated protein kinase 2
Uniprot ID
O75116
Protein Name Alias
EC 2.7.11.1; Rho kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; ROCK-II; p164 ROCK-2
Gene ID
9475
Gene Symbol
ROCK2
Gene Alias
KIAA0619
TTD
T06093: Clinical Trial target
Pfam
PF00069
;
PF08912
GO
1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
0106310:protein serine kinase activity
0002931:response to ischemia
0004674:protein serine/threonine kinase activity
0061157:mRNA destabilization
0018105:peptidyl-serine phosphorylation
0032956:regulation of actin cytoskeleton organization
0045019:negative regulation of nitric oxide biosynthetic process
0010825:positive regulation of centrosome duplication
0010629:negative regulation of gene expression
1903347:negative regulation of bicellular tight junction assembly
0031267:small GTPase binding
0010613:positive regulation of cardiac muscle hypertrophy
0051298:centrosome duplication
0007186:G protein-coupled receptor signaling pathway
0045616:regulation of keratinocyte differentiation
0031644:regulation of nervous system process
2000114:regulation of establishment of cell polarity
0005829:cytosol
0051496:positive regulation of stress fiber assembly
1905205:positive regulation of connective tissue replacement
1903140:regulation of establishment of endothelial barrier
1901888:regulation of cell junction assembly
0071559:response to transforming growth factor beta
0005737:cytoplasm
0006939:smooth muscle contraction
0010628:positive regulation of gene expression
0005524:ATP binding
1902966:positive regulation of protein localization to early endosome
0001934:positive regulation of protein phosphorylation
0018107:peptidyl-threonine phosphorylation
0006468:protein phosphorylation
0030866:cortical actin cytoskeleton organization
0046872:metal ion binding
0007249:I-kappaB kinase/NF-kappaB signaling
0070168:negative regulation of biomineral tissue development
1900037:regulation of cellular response to hypoxia
0005634:nucleus
0043410:positive regulation of MAPK cascade
0090271:positive regulation of fibroblast growth factor production
0051492:regulation of stress fiber assembly
0106311:protein threonine kinase activity
0110061:regulation of angiotensin-activated signaling pathway
0042752:regulation of circadian rhythm
1990776:response to angiotensin
0050321:tau-protein kinase activity
0039694:viral RNA genome replication
0032723:positive regulation of connective tissue growth factor production
0005198:structural molecule activity
0150033:negative regulation of protein localization to lysosome
0048013:ephrin receptor signaling pathway
0005856:cytoskeleton
1902993:positive regulation of amyloid precursor protein catabolic process
0048511:rhythmic process
0003723:RNA binding
0072659:protein localization to plasma membrane
1905145:cellular response to acetylcholine
0000281:mitotic cytokinesis
0016525:negative regulation of angiogenesis
0030335:positive regulation of cell migration
0031032:actomyosin structure organization
0010595:positive regulation of endothelial cell migration
0005813:centrosome
0035509:negative regulation of myosin-light-chain-phosphatase activity
0048010:vascular endothelial growth factor receptor signaling pathway
0036464:cytoplasmic ribonucleoprotein granule
0005886:plasma membrane
0048598:embryonic morphogenesis
0030155:regulation of cell adhesion
0003180:aortic valve morphogenesis
0048156:tau protein binding
0051893:regulation of focal adhesion assembly
0072518:Rho-dependent protein serine/threonine kinase activity
0097746:blood vessel diameter maintenance
0071394:cellular response to testosterone stimulus
2000145:regulation of cell motility
1902004:positive regulation of amyloid-beta formation
0051246:regulation of protein metabolic process
0007266:Rho protein signal transduction
PDB
7JOV
;
6P5P
;
5U7R
;
5U7Q
;
4WOT
;
6P5M
;
7JNT
;
4L6Q
;
6ED6
Drugbank
DB13931
;
DB12010
;
DB08756
;
DB08162
;
DB13165
KEGG
hsa:9475
Related Compounds (Total: 1)
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C0210
Name: Melatonin
Related Herbs (Total: 3)
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Herb id
Chinese Pin Yin
Chinese Character
English Name
Latin Name
H0847
Zi He Che
紫河车
Human placenta
Homo sapiens
H0446
Sheng Jiang
生姜
Fresh common ginger
Zingiber officinale
H0360
Ren Zhong Bai
人中白
Human urine sediment
Homo sapiens