HIT-result

Type	Detail
Target ID	T80OP0
Protein Name	Alternative prion protein;Major prion protein
Uniprot ID	F7VJQ1 ; P04156
Protein Name Alias	NA
Gene ID	5621
Gene Symbol	PRNP
Gene Alias	NA
TTD	T08722: Research target
Pfam	PF11587 ; PF00377
GO	0042802:identical protein binding 0005634:nucleus 1902951:negative regulation of dendritic spine maintenance 0038023:signaling receptor activity 0070062:extracellular exosome 0007050:cell cycle arrest 0035584:calcium-mediated signaling using intracellular calcium source 0001540:amyloid-beta binding 1900449:regulation of glutamate receptor signaling pathway 0005829:cytosol 1902938:regulation of intracellular calcium activated chloride channel activity 0032689:negative regulation of interferon-gamma production 0016234:inclusion body 0097062:dendritic spine maintenance 0005507:copper ion binding 0098794:postsynapse 0019828:aspartic-type endopeptidase inhibitor activity 0009986:cell surface 0043525:positive regulation of neuron apoptotic process 1902430:negative regulation of amyloid-beta formation 0014069:postsynaptic density 0007611:learning or memory 0046007:negative regulation of activated T cell proliferation 1905664:regulation of calcium ion import across plasma membrane 0005737:cytoplasm 0008017:microtubule binding 0005509:calcium ion binding 0031802:type 5 metabotropic glutamate receptor binding 0006878:cellular copper ion homeostasis 0090647:modulation of age-related behavioral decline 0050730:regulation of peptidyl-tyrosine phosphorylation 0016021:integral component of membrane 0044877:protein-containing complex binding 0031648:protein destabilization 0045048:protein insertion into ER membrane 0005783:endoplasmic reticulum 0005886:plasma membrane 0070885:negative regulation of calcineurin-NFAT signaling cascade 0050731:positive regulation of peptidyl-tyrosine phosphorylation 1904645:response to amyloid-beta 0043231:intracellular membrane-bounded organelle 0045121:membrane raft 0005741:mitochondrial outer membrane 0031965:nuclear membrane 0001933:negative regulation of protein phosphorylation 0002020:protease binding 1901216:positive regulation of neuron death 1903136:cuprous ion binding 0019898:extrinsic component of membrane 0050860:negative regulation of T cell receptor signaling pathway 0006979:response to oxidative stress 0031362:anchored component of external side of plasma membrane 0010955:negative regulation of protein processing 0005794:Golgi apparatus 1904646:cellular response to amyloid-beta 0043433:negative regulation of DNA-binding transcription factor activity 0061098:positive regulation of protein tyrosine kinase activity 0032700:negative regulation of interleukin-17 production 0015631:tubulin binding 0071280:cellular response to copper ion 0032703:negative regulation of interleukin-2 production 0007616:long-term memory 0005539:glycosaminoglycan binding 1990535:neuron projection maintenance 1902992:negative regulation of amyloid precursor protein catabolic process 0051260:protein homooligomerization 0090314:positive regulation of protein targeting to membrane
PDB	2LV1 ; 4DGI ; 1E1J ; 2IV6 ; 6PQA ; 2K1D ; 1HJN ; 3HAK ; 4KML ; 1E1W ; 6SV2 ; 3MD5 ; 4E1I ; 6DU9 ; 6LNI ; 2OL9 ; 4E1H ; 5YJ4 ; 1QM2 ; 4N9O ; 1E1P ; 1QLX ; 3HJX ; 3NVF ; 1E1G ; 5YJ5 ; 1HJM ; 2W9E ; 3NHC ; 1QM0 ; 1OEI ; 1E1S ; 1FKC ; 2M8T ; 2LBG ; 5L6R ; 6SUZ ; 3NHD ; 3MD4 ; 3HES ; 3HJ5 ; 1FO7 ; 3HEQ ; 1E1U ; 2LEJ ; 2IV4 ; 2LFT ; 3HAF ; 1QM1 ; 6PQ5 ; 1QM3 ; 6UUR ; 2LSB ; 1H0L ; 1I4M ; 2IV5 ; 3HER ; 1QLZ ; 1OEH ; 2KUN
Drugbank	DB00759 ; DB09130
KEGG	hsa:5621

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Name: Melatonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens