HIT-result

Type	Detail
Target ID	T62Z4P
Protein Name	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Uniprot ID	P16615
Protein Name Alias	SERCA2; SR Ca(2+)-ATPase 2; EC 7.2.2.10; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Gene ID	488
Gene Symbol	ATP2A2
Gene Alias	ATP2B
TTD	T15377: Clinical Trial target
Pfam	PF00690 ; PF00689
GO	0034976:response to endoplasmic reticulum stress 0007155:cell adhesion 0016887:ATPase activity 0032470:positive regulation of endoplasmic reticulum calcium ion concentration 0005789:endoplasmic reticulum membrane 0097470:ribbon synapse 0014898:cardiac muscle hypertrophy in response to stress 0031095:platelet dense tubular network membrane 0044548:S100 protein binding 0034599:cellular response to oxidative stress 1903515:calcium ion transport from cytosol to endoplasmic reticulum 0010882:regulation of cardiac muscle contraction by calcium ion signaling 0055119:relaxation of cardiac muscle 0031234:extrinsic component of cytoplasmic side of plasma membrane 0005509:calcium ion binding 0090534:calcium ion-transporting ATPase complex 0006984:ER-nucleus signaling pathway 1990036:calcium ion import into sarcoplasmic reticulum 0070588:calcium ion transmembrane transport 0002026:regulation of the force of heart contraction 0005887:integral component of plasma membrane 0006874:cellular calcium ion homeostasis 0005524:ATP binding 0005783:endoplasmic reticulum 0048471:perinuclear region of cytoplasm 0086039:calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential 0019899:enzyme binding 0045822:negative regulation of heart contraction 1900121:negative regulation of receptor binding 1903779:regulation of cardiac conduction 0070296:sarcoplasmic reticulum calcium ion transport 0140056:organelle localization by membrane tethering 1903233:regulation of calcium ion-dependent exocytosis of neurotransmitter 0120025:plasma membrane bounded cell projection 0008544:epidermis development 0033017:sarcoplasmic reticulum membrane 0003009:skeletal muscle contraction 0016020:membrane 0016529:sarcoplasmic reticulum 0012506:vesicle membrane 0032991:protein-containing complex 0034220:ion transmembrane transport 0044325:ion channel binding 0033292:T-tubule organization 0016240:autophagosome membrane docking 0061831:apical ectoplasmic specialization 0008553:proton-exporting ATPase activity, phosphorylative mechanism 0014883:transition between fast and slow fiber 0031775:lutropin-choriogonadotropic hormone receptor binding 0086036:regulation of cardiac muscle cell membrane potential 0008022:protein C-terminus binding 0000045:autophagosome assembly 0032496:response to lipopolysaccharide 0034605:cellular response to heat 1990456:mitochondrion-endoplasmic reticulum membrane tethering 0032469:endoplasmic reticulum calcium ion homeostasis 0098909:regulation of cardiac muscle cell action potential involved in regulation of contraction 0014801:longitudinal sarcoplasmic reticulum 0005388:calcium transmembrane transporter activity, phosphorylative mechanism 0010460:positive regulation of heart rate
PDB	7BT2 ; 5ZTF ; 6LN8 ; 6JJU ; 6LLY ; 6LN9 ; 6LN6 ; 6LN7 ; 6LLE ; 6LN5
Drugbank	DB06157 ; DB01189
KEGG	hsa:488

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Name: Melatonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens