HIT-result

Type	Detail
Target ID	T15UBS
Protein Name	Suppressor of cytokine signaling 1
Uniprot ID	O15524
Protein Name Alias	SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3
Gene ID	8651
Gene Symbol	SOCS1
Gene Alias	SSI1; TIP3
TTD	T06800: Research target
Pfam	PF00017
GO	0046935:1-phosphatidylinositol-3-kinase regulator activity 0042532:negative regulation of tyrosine phosphorylation of STAT protein 0019221:cytokine-mediated signaling pathway 0046854:phosphatidylinositol phosphorylation 0001932:regulation of protein phosphorylation 0005829:cytosol 0043372:positive regulation of CD4-positive, alpha-beta T cell differentiation 0045591:positive regulation of regulatory T cell differentiation 0001817:regulation of cytokine production 0016567:protein ubiquitination 0005654:nucleoplasm 0019210:kinase inhibitor activity 0071230:cellular response to amino acid stimulus 0035556:intracellular signal transduction 0040008:regulation of growth 0036464:cytoplasmic ribonucleoprotein granule 0031410:cytoplasmic vesicle 0045444:fat cell differentiation 0046627:negative regulation of insulin receptor signaling pathway 0007259:receptor signaling pathway via JAK-STAT 0010533:regulation of activation of Janus kinase activity 0038111:interleukin-7-mediated signaling pathway 0004860:protein kinase inhibitor activity 0043377:negative regulation of CD8-positive, alpha-beta T cell differentiation 0019901:protein kinase binding 0005159:insulin-like growth factor receptor binding 0046426:negative regulation of receptor signaling pathway via JAK-STAT 0005942:phosphatidylinositol 3-kinase complex 0005737:cytoplasm 0060334:regulation of interferon-gamma-mediated signaling pathway
PDB	NA
Drugbank	NA
KEGG	hsa:8651

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H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
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H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
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H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens