HIT-result

Type	Detail
Target ID	T60DK9
Protein Name	Rho-associated protein kinase 1
Uniprot ID	Q13464
Protein Name Alias	EC 2.7.11.1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
Gene ID	6093
Gene Symbol	ROCK1
Gene Alias	NA
TTD	T51282: Successful target
Pfam	PF00069 ; PF08912
GO	0004672:protein kinase activity 0106310:protein serine kinase activity 0050900:leukocyte migration 0004674:protein serine/threonine kinase activity 0061157:mRNA destabilization 1902003:regulation of amyloid-beta formation 0001726:ruffle 0018105:peptidyl-serine phosphorylation 0032956:regulation of actin cytoskeleton organization 0031175:neuron projection development 0051451:myoblast migration 1903347:negative regulation of bicellular tight junction assembly 0031267:small GTPase binding 1900223:positive regulation of amyloid-beta clearance 1900242:regulation of synaptic vesicle endocytosis 0005576:extracellular region 0010613:positive regulation of cardiac muscle hypertrophy 0030027:lamellipodium 0007186:G protein-coupled receptor signaling pathway 0045616:regulation of keratinocyte differentiation 0051894:positive regulation of focal adhesion assembly 0022614:membrane to membrane docking 2000114:regulation of establishment of cell polarity 0005829:cytosol 1905205:positive regulation of connective tissue replacement 1903140:regulation of establishment of endothelial barrier 1902430:negative regulation of amyloid-beta formation 1901888:regulation of cell junction assembly 0000139:Golgi membrane 0071559:response to transforming growth factor beta 0005737:cytoplasm 0006939:smooth muscle contraction 0010628:positive regulation of gene expression 0005524:ATP binding 0018107:peptidyl-threonine phosphorylation 0005814:centriole 0051045:negative regulation of membrane protein ectodomain proteolysis 0006468:protein phosphorylation 0032091:negative regulation of protein binding 0030866:cortical actin cytoskeleton organization 0046872:metal ion binding 0010506:regulation of autophagy 1902992:negative regulation of amyloid precursor protein catabolic process 0007249:I-kappaB kinase/NF-kappaB signaling 0070168:negative regulation of biomineral tissue development 0043410:positive regulation of MAPK cascade 0140058:neuron projection arborization 0051492:regulation of stress fiber assembly 0106311:protein threonine kinase activity 0110061:regulation of angiotensin-activated signaling pathway 1990776:response to angiotensin 0050321:tau-protein kinase activity 0032059:bleb 0045664:regulation of neuron differentiation 0048013:ephrin receptor signaling pathway 0005856:cytoskeleton 0043312:neutrophil degranulation 0072659:protein localization to plasma membrane 0042326:negative regulation of phosphorylation 0034774:secretory granule lumen 0000281:mitotic cytokinesis 0016525:negative regulation of angiogenesis 0030334:regulation of cell migration 0019828:aspartic-type endopeptidase inhibitor activity 0031032:actomyosin structure organization 0090521:glomerular visceral epithelial cell migration 0035509:negative regulation of myosin-light-chain-phosphatase activity 0048010:vascular endothelial growth factor receptor signaling pathway 0006915:apoptotic process 0030036:actin cytoskeleton organization 0005886:plasma membrane 0048598:embryonic morphogenesis 0050901:leukocyte tethering or rolling 0030155:regulation of cell adhesion 0003180:aortic valve morphogenesis 0048156:tau protein binding 0070507:regulation of microtubule cytoskeleton organization 0010508:positive regulation of autophagy 0051893:regulation of focal adhesion assembly 0072518:Rho-dependent protein serine/threonine kinase activity 0007159:leukocyte cell-cell adhesion 0097746:blood vessel diameter maintenance 0010494:cytoplasmic stress granule 0007165:signal transduction 2000145:regulation of cell motility 0007266:Rho protein signal transduction
PDB	5BML ; 4L2W ; 2V55 ; 1S1C ; 3V8S ; 5KKT ; 3NCZ ; 6E9W ; 5WNH ; 2ESM ; 4YVE ; 3TV7 ; 4W7P ; 5WNE ; 3TWJ ; 5KKS ; 2ETR ; 3NDM ; 5HVU ; 4YVC ; 7JOU ; 2ETK ; 5F5P ; 3O0Z ; 5UZJ ; 5WNG ; 3D9V ; 5WNF
Drugbank	DB13931 ; DB08756 ; DB08162 ; DB07876 ; DB13165 ; DB04707
KEGG	hsa:6093

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Name: Triptolide

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum