Compound Description
| ID: C1180 | Common name: Betulinic Acid |
| IUPAC: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid | CAS: CAS:472-15-1 |
| Chembl ID: CHEMBL269277 | Pubchem ID: CID:64971 |
| Formula: C30H48O3 | TCM-ID: TCMC804 |
| Smiles: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O | |
| Alias:
Lup-20(29)-en-28-oic acid, 3β-hydroxy-;
Mairin; (3β)-3-Hydroxylup-20(29)-en-28-oic acid; 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.; (+)-Betulinic acid; 3β-Hydroxylup-20(29)-en-28-oic acid; Betulic acid; Betulinic acid; Lupatic acid; NSC 113090; β-Betulinic acid |
Structure:
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Related Targets (Total: 9)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
A | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T74P7I | G-protein coupled bile acid receptor 1 | GPBAR1 |
Q8TDU6 |
A | 2 Reference(s) |
| T02O3F | Endothelial lipase | LIPG |
Q9Y5X9 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 1 Reference(s) |
| T41A4Y | Lamin-B1 | LMNB1 |
P20700 |
B | 1 Reference(s) |
| T23EWB | Transcriptional repressor protein YY1 | YY1 |
P25490 |
C | 1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 59)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1186 | Hong Gen Cao | 红根草 | Hispid sage | Salvia prionitis |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0780 | Zao Pi | 枣皮 | Varieties | Ziziphus jujuba mill. var. inermis (bge.) rehd. |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0277 | Nan Ban Lan Gen | 南板蓝根 | Indigowoad root | Baphicacanthus cusia |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0461 | Shi Jun Zi Ren | 使君子仁 | NA | Combretum indicum |
| H0229 | Mao Da Ding Cao | 毛大丁草 | Pilose gerbera | Gerbera piloselloides |
| H0158 | Liu Ling Ju | 六棱菊 | NA | Laggera alata |
| H0470 | Shi Ye | 柿叶 | Persimmon leaf | Diospyros kaki |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0160 | Liu Zhi | 柳枝 | Babylon weeping willow branch | Salix babylonica |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0968 | Di Feng Pi | 地枫皮 | Difengpi anisetree | Illicium difengpi |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0258 | Mo Han Lian | 墨旱莲 | Yerbadetajo | Eclipta prostrata |
| H0496 | Shui Ze Lan | 水泽兰 | NA | Lycopus lucidus |
| H1205 | Hu Lu Cha | 葫芦茶 | Triquetrous tadehagi | Tadehagi triquetrum |
| H1179 | Hei Mian Shen | 黑面神 | Leaf and twig of fruticose breynia | Breynia fruticosa |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0801 | Chong Bai La | 虫白蜡 | Cera chinensis wax | Ericerus pela |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0829 | Zhu Jie Xiang Fu | 竹节香附 | rhizome of radde anemone | Anemone raddeana |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0989 | Ding Kui Cao | 丁葵草 | Herb of twinleaf zornia | Kummerowia striata |
| H0591 | Wei Ling Cai | 委陵菜 | Chinese cinquefoil | Potentilla chinensis |
| H0453 | Shi Di | 柿蒂 | Persimmon persistent calyx | Diospyros kaki |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0361 | Ren Zi Cao | 人字草 | Herb of twinleaf zornia | Kummerowia striata |
| H0278 | Nan Ban Lan Gen Jin Gao Fen | 南板蓝根浸膏粉 | Indigowoad root | Baphicacanthus cusia |
| H0775 | Yun Zhi | 云芝 | Coriolus versicolor | Polysaccharidum versicolor |
| H0940 | Da Ye Zi Zhu | 大叶紫珠 | Bigleaf beautyberry | Callicarpa macrophylla |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H1211 | Bai Mei | 白眉 | pilose gerbera herb | Gerbera piloselloides |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H0020 | Ji Yan Cao | 鸡眼草 | Striate kummerowia | Kummerowia striata |
| H0727 | Ye Gan Cao | 野甘草 | Sweet broomwort | Scoparia dulcis |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
Ckey description of the interaction between compound and target