Target Description

Type Detail
Target ID T81I6O
Protein Name Nucleophosmin
Uniprot ID P06748
Protein Name Alias NPM;  Nucleolar phosphoprotein B23;  Nucleolar protein NO38;  Numatrin
Gene ID 4869
Gene Symbol NPM1
Gene Alias NPM
TTD T45591: Clinical Trial target
Pfam PF03066 ; PF16276
GO
0033613:activating transcription factor binding

0005634:nucleus

1902751:positive regulation of cell cycle G2/M phase transition

0005829:cytosol

0006886:intracellular protein transport

0001046:core promoter sequence-specific DNA binding

0016020:membrane

0032991:protein-containing complex

0006334:nucleosome assembly

0006281:DNA repair

0046599:regulation of centriole replication

1902629:regulation of mRNA stability involved in cellular response to UV

0030957:Tat protein binding

0005813:centrosome

0042803:protein homodimerization activity

1990904:ribonucleoprotein complex

0043066:negative regulation of apoptotic process

0042393:histone binding

0032993:protein-DNA complex

0005654:nucleoplasm

0045893:positive regulation of transcription, DNA-templated

0045944:positive regulation of transcription by RNA polymerase II

0060735:regulation of eIF2 alpha phosphorylation by dsRNA

0003682:chromatin binding

0007165:signal transduction

0060699:regulation of endoribonuclease activity

0008285:negative regulation of cell population proliferation

0034644:cellular response to UV

0010824:regulation of centrosome duplication

0042273:ribosomal large subunit biogenesis

0006357:regulation of transcription by RNA polymerase II

0042255:ribosome assembly

0005730:nucleolus

0005925:focal adhesion

0008134:transcription factor binding

0006407:rRNA export from nucleus

0000055:ribosomal large subunit export from nucleus

0003713:transcription coactivator activity

0044387:negative regulation of protein kinase activity by regulation of protein phosphorylation

0008104:protein localization

0000056:ribosomal small subunit export from nucleus

0006913:nucleocytoplasmic transport

0051082:unfolded protein binding

0004860:protein kinase inhibitor activity

0051059:NF-kappaB binding

0007569:cell aging

0010826:negative regulation of centrosome duplication

0051092:positive regulation of NF-kappaB transcription factor activity

0034080:CENP-A containing nucleosome assembly

0006338:chromatin remodeling

0019901:protein kinase binding

0008284:positive regulation of cell population proliferation

0032071:regulation of endodeoxyribonuclease activity

0043024:ribosomal small subunit binding

0043023:ribosomal large subunit binding

0005737:cytoplasm

0007098:centrosome cycle

0031616:spindle pole centrosome

0042274:ribosomal small subunit biogenesis

0045727:positive regulation of translation

0003723:RNA binding

0016032:viral process

PDB 2LLH ; 2P1B ; 5EHD ; 2VXD
Drugbank DB11638
KEGG hsa:4869

Related Compounds  (Total: 2)

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C0003
Name: Deguelin
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C0428
Name: Tanshinone Iia


Related Herbs  (Total: 7)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0683 Xiu Xian Ju绣线菊 Japanese spiraeaSpiraea japonica
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0669 Xie Bai薤白 Longstamen onionAllium macrostemon
H0323 Qian Hu前胡 Common hogfennelAngelica decursiva
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum