HIT-result

Target Description

Type	Detail
Target ID	T81I6O
Protein Name	Nucleophosmin
Uniprot ID	P06748
Protein Name Alias	NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
Gene ID	4869
Gene Symbol	NPM1
Gene Alias	NPM
TTD	T45591: Clinical Trial target
Pfam	PF03066 ; PF16276
GO	0033613:activating transcription factor binding 0005634:nucleus 1902751:positive regulation of cell cycle G2/M phase transition 0005829:cytosol 0006886:intracellular protein transport 0001046:core promoter sequence-specific DNA binding 0016020:membrane 0032991:protein-containing complex 0006334:nucleosome assembly 0006281:DNA repair 0046599:regulation of centriole replication 1902629:regulation of mRNA stability involved in cellular response to UV 0030957:Tat protein binding 0005813:centrosome 0042803:protein homodimerization activity 1990904:ribonucleoprotein complex 0043066:negative regulation of apoptotic process 0042393:histone binding 0032993:protein-DNA complex 0005654:nucleoplasm 0045893:positive regulation of transcription, DNA-templated 0045944:positive regulation of transcription by RNA polymerase II 0060735:regulation of eIF2 alpha phosphorylation by dsRNA 0003682:chromatin binding 0007165:signal transduction 0060699:regulation of endoribonuclease activity 0008285:negative regulation of cell population proliferation 0034644:cellular response to UV 0010824:regulation of centrosome duplication 0042273:ribosomal large subunit biogenesis 0006357:regulation of transcription by RNA polymerase II 0042255:ribosome assembly 0005730:nucleolus 0005925:focal adhesion 0008134:transcription factor binding 0006407:rRNA export from nucleus 0000055:ribosomal large subunit export from nucleus 0003713:transcription coactivator activity 0044387:negative regulation of protein kinase activity by regulation of protein phosphorylation 0008104:protein localization 0000056:ribosomal small subunit export from nucleus 0006913:nucleocytoplasmic transport 0051082:unfolded protein binding 0004860:protein kinase inhibitor activity 0051059:NF-kappaB binding 0007569:cell aging 0010826:negative regulation of centrosome duplication 0051092:positive regulation of NF-kappaB transcription factor activity 0034080:CENP-A containing nucleosome assembly 0006338:chromatin remodeling 0019901:protein kinase binding 0008284:positive regulation of cell population proliferation 0032071:regulation of endodeoxyribonuclease activity 0043024:ribosomal small subunit binding 0043023:ribosomal large subunit binding 0005737:cytoplasm 0007098:centrosome cycle 0031616:spindle pole centrosome 0042274:ribosomal small subunit biogenesis 0045727:positive regulation of translation 0003723:RNA binding 0016032:viral process
PDB	2LLH ; 2P1B ; 5EHD ; 2VXD
Drugbank	DB11638
KEGG	hsa:4869

Type

Detail

Target ID

T81I6O

Protein Name

Nucleophosmin

Uniprot ID

P06748

Protein Name Alias

NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin

Gene ID

4869

Gene Symbol

NPM1

Gene Alias

NPM

TTD

T45591: Clinical Trial target

Pfam

PF03066 ; PF16276

0033613:activating transcription factor binding

0005634:nucleus

1902751:positive regulation of cell cycle G2/M phase transition

0005829:cytosol

0006886:intracellular protein transport

0001046:core promoter sequence-specific DNA binding

0016020:membrane

0032991:protein-containing complex

0006334:nucleosome assembly

0006281:DNA repair

0046599:regulation of centriole replication

1902629:regulation of mRNA stability involved in cellular response to UV

0030957:Tat protein binding

0005813:centrosome

0042803:protein homodimerization activity

1990904:ribonucleoprotein complex

0043066:negative regulation of apoptotic process

0042393:histone binding

0032993:protein-DNA complex

0005654:nucleoplasm

0045893:positive regulation of transcription, DNA-templated

0045944:positive regulation of transcription by RNA polymerase II

0060735:regulation of eIF2 alpha phosphorylation by dsRNA

0003682:chromatin binding

0007165:signal transduction

0060699:regulation of endoribonuclease activity

0008285:negative regulation of cell population proliferation

0034644:cellular response to UV

0010824:regulation of centrosome duplication

0042273:ribosomal large subunit biogenesis

0006357:regulation of transcription by RNA polymerase II

0042255:ribosome assembly

0005730:nucleolus

0005925:focal adhesion

0008134:transcription factor binding

0006407:rRNA export from nucleus

0000055:ribosomal large subunit export from nucleus

0003713:transcription coactivator activity

0044387:negative regulation of protein kinase activity by regulation of protein phosphorylation

0008104:protein localization

0000056:ribosomal small subunit export from nucleus

0006913:nucleocytoplasmic transport

0051082:unfolded protein binding

0004860:protein kinase inhibitor activity

0051059:NF-kappaB binding

0007569:cell aging

0010826:negative regulation of centrosome duplication

0051092:positive regulation of NF-kappaB transcription factor activity

0034080:CENP-A containing nucleosome assembly

0006338:chromatin remodeling

0019901:protein kinase binding

0008284:positive regulation of cell population proliferation

0032071:regulation of endodeoxyribonuclease activity

0043024:ribosomal small subunit binding

0043023:ribosomal large subunit binding

0005737:cytoplasm

0007098:centrosome cycle

0031616:spindle pole centrosome

0042274:ribosomal small subunit biogenesis

0045727:positive regulation of translation

0003723:RNA binding

0016032:viral process

PDB

2LLH ; 2P1B ; 5EHD ; 2VXD

Drugbank

DB11638

KEGG

hsa:4869

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0683	Xiu Xian Ju	绣线菊	Japanese spiraea	Spiraea japonica
H0323	Qian Hu	前胡	Common hogfennel	Angelica decursiva
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 7)