HIT-result

ID: C0428	Common name: Tanshinone Iia
IUPAC: 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione	CAS: CAS:568-72-9
Chembl ID: CHEMBL187266	Pubchem ID: CID:164676
Formula: C19H18O3	TCM-ID: TCMC2127
Smiles: CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Alias: Tanshinone IIA; 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; 1,6,6-Trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione; Dan Shen ketone; NSC 686518; NSC 686519; Salviol IIA; Tanshinon II; Tanshinone B; Tanshinone II; Tashinone IIA	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T26KIE	Transcription factor AP-1	JUN	P05412	A	1 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	A	1 Reference(s)
T50SX0	Nuclear receptor subfamily 1 group I member 2	NR1I2	O75469	A	1 Reference(s)
T44LWL	Transcription factor p65	RELA	Q04206	A	1 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	A	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	A	1 Reference(s)
T53FF1	S-phase kinase-associated protein 2	SKP2	Q13309	A	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	A	1 Reference(s)
T75NEV	Aquaporin-1	AQP1	P29972	A	1 Reference(s)
T29MD1	Mitogen-activated protein kinase 8	MAPK8	P45983	A	2 Reference(s)
T48YPL	Aquaporin-3	AQP3	Q92482	A	1 Reference(s)
T53SLQ	Aquaporin-9	AQP9	O43315	A	1 Reference(s)
T89EW0	Aquaporin-8	AQP8	O94778	A	1 Reference(s)
T11BI7	Toll-like receptor 4	TLR4	O00206	A	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	A	1 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	A	1 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	B	1 Reference(s)
T31SX8	Bone morphogenetic protein 2	BMP2	P12643	B	1 Reference(s)
T45G32	Proto-oncogene tyrosine-protein kinase Src	SRC	P12931	C	1 Reference(s)
T82G3R	Integrin beta-3	ITGB3	P05106	C	1 Reference(s)
T92CLX	Calcitonin receptor	CALCR	P30988	C	1 Reference(s)
T81I6O	Nucleophosmin	NPM1	P06748	C	1 Reference(s)
T02QBS	Cytochrome P450 1A2	CYP1A2	P05177	C	1 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	C	1 Reference(s)
T85AXP	Cytochrome P450 3A4	CYP3A4	P08684	C	1 Reference(s)
T64W2K	Cyclin-dependent kinase inhibitor 1	CDKN1A	P38936	C	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	C	1 Reference(s)
T82JWE	Cellular tumor antigen p53	TP53	P04637	C	1 Reference(s)
T34E5V	Endothelin-1 receptor	EDNRA	P25101	C	1 Reference(s)
T90ZS8	Endothelin-converting enzyme 1	ECE1	P42892	C	1 Reference(s)
T93VFT	Endothelin-1	EDN1	P05305	C	1 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	C	2 Reference(s)
T26EZU	Myc proto-oncogene protein	MYC	P01106	C	1 Reference(s)
T64UH1	Nitric oxide synthase, endothelial	NOS3	P29474	C	1 Reference(s)
T67LQK	Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)	MAPK11	Q15759	C	1 Reference(s)
T71BDH	Mitogen-activated protein kinase 14	MAPK14	Q16539	C	1 Reference(s)
T22OPB	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236	C	1 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0323	Qian Hu	前胡	Common hogfennel	Angelica decursiva
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza

Compound Description

Related Targets (Total: 38)

Related Herbs (Total: 5)