HIT-result

ID: C0428	Common name: Tanshinone Iia
IUPAC: 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione	CAS: CAS:568-72-9
Chembl ID: CHEMBL187266	Pubchem ID: CID:164676
Formula: C19H18O3	TCM-ID: TCMC2127
Smiles: CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Alias: Tanshinone IIA; 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; 1,6,6-Trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione; Dan Shen ketone; NSC 686518; NSC 686519; Salviol IIA; Tanshinon II; Tanshinone B; Tanshinone II; Tashinone IIA	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T26KIE	Transcription factor AP-1	JUN	P05412	A	1 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	A	1 Reference(s)
T50SX0	Nuclear receptor subfamily 1 group I member 2	NR1I2	O75469	A	1 Reference(s)
T44LWL	Transcription factor p65	RELA	Q04206	A	1 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	A	1 Reference(s)
T49TDM	Matrix metalloproteinase-9	MMP9	P14780	A	1 Reference(s)
T53FF1	S-phase kinase-associated protein 2	SKP2	Q13309	A	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	A	1 Reference(s)
T75NEV	Aquaporin-1	AQP1	P29972	A	1 Reference(s)
T29MD1	Mitogen-activated protein kinase 8	MAPK8	P45983	A	2 Reference(s)
T48YPL	Aquaporin-3	AQP3	Q92482	A	1 Reference(s)
T53SLQ	Aquaporin-9	AQP9	O43315	A	1 Reference(s)
T89EW0	Aquaporin-8	AQP8	O94778	A	1 Reference(s)
T11BI7	Toll-like receptor 4	TLR4	O00206	A	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	A	1 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	A	1 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	B	1 Reference(s)
T31SX8	Bone morphogenetic protein 2	BMP2	P12643	B	1 Reference(s)
T45G32	Proto-oncogene tyrosine-protein kinase Src	SRC	P12931	C	1 Reference(s)
T82G3R	Integrin beta-3	ITGB3	P05106	C	1 Reference(s)
T92CLX	Calcitonin receptor	CALCR	P30988	C	1 Reference(s)
T81I6O	Nucleophosmin	NPM1	P06748	C	1 Reference(s)
T02QBS	Cytochrome P450 1A2	CYP1A2	P05177	C	1 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	C	1 Reference(s)
T85AXP	Cytochrome P450 3A4	CYP3A4	P08684	C	1 Reference(s)
T64W2K	Cyclin-dependent kinase inhibitor 1	CDKN1A	P38936	C	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	C	1 Reference(s)
T82JWE	Cellular tumor antigen p53	TP53	P04637	C	1 Reference(s)
T34E5V	Endothelin-1 receptor	EDNRA	P25101	C	1 Reference(s)
T90ZS8	Endothelin-converting enzyme 1	ECE1	P42892	C	1 Reference(s)
T93VFT	Endothelin-1	EDN1	P05305	C	1 Reference(s)
T71K92	Apoptosis regulator Bcl-2	BCL2	P10415	C	2 Reference(s)
T26EZU	Myc proto-oncogene protein	MYC	P01106	C	1 Reference(s)
T64UH1	Nitric oxide synthase, endothelial	NOS3	P29474	C	1 Reference(s)
T67LQK	Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)	MAPK11	Q15759	C	1 Reference(s)
T71BDH	Mitogen-activated protein kinase 14	MAPK14	Q16539	C	1 Reference(s)
T22OPB	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236	C	1 Reference(s)
T80TUC	Apoptosis regulator BAX	BAX	Q07812	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0323	Qian Hu	前胡	Common hogfennel	Angelica decursiva
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum

Compound Description

Related Targets (Total: 38)

Related Herbs (Total: 5)