HIT-result

Target Description

Type	Detail
Target ID	T16K98
Protein Name	Protein jagged-1
Uniprot ID	P78504
Protein Name Alias	Jagged1; hJ1; CD antigen CD339
Gene ID	182
Gene Symbol	JAG1
Gene Alias	JAGL1
TTD	NA
Pfam	PF07657 ; PF00008 ; PF12661 ; PF07645 ; PF01414
GO	2000737:negative regulation of stem cell differentiation 0045747:positive regulation of Notch signaling pathway 0005543:phospholipid binding 0001974:blood vessel remodeling 0060411:cardiac septum morphogenesis 0042127:regulation of cell population proliferation 0062043:positive regulation of cardiac epithelial to mesenchymal transition 0003180:aortic valve morphogenesis 0005576:extracellular region 0003215:cardiac right ventricle morphogenesis 0030216:keratinocyte differentiation 0016020:membrane 0002456:T cell mediated immunity 0045639:positive regulation of myeloid cell differentiation 0005912:adherens junction 0001525:angiogenesis 0007399:nervous system development 0005886:plasma membrane 0007219:Notch signaling pathway 0072015:glomerular visceral epithelial cell development 0003184:pulmonary valve morphogenesis 0072070:loop of Henle development 0005112:Notch binding 0045602:negative regulation of endothelial cell differentiation 0022408:negative regulation of cell-cell adhesion 0061444:endocardial cushion cell development 0005198:structural molecule activity 0061156:pulmonary artery morphogenesis 0030336:negative regulation of cell migration 0005509:calcium ion binding 0035909:aorta morphogenesis 0061309:cardiac neural crest cell development involved in outflow tract morphogenesis 0045665:negative regulation of neuron differentiation 0042491:inner ear auditory receptor cell differentiation 0002011:morphogenesis of an epithelial sheet 0045446:endothelial cell differentiation 0072017:distal tubule development 0045445:myoblast differentiation 0008083:growth factor activity 0097150:neuronal stem cell population maintenance 0061314:Notch signaling involved in heart development 0045669:positive regulation of osteoblast differentiation 0001953:negative regulation of cell-matrix adhesion 0030097:hemopoiesis 0005887:integral component of plasma membrane 0072006:nephron development 0001709:cell fate determination 0045944:positive regulation of transcription by RNA polymerase II 0045599:negative regulation of fat cell differentiation 0032495:response to muramyl dipeptide 0016324:apical plasma membrane 0061073:ciliary body morphogenesis
PDB	2KB9 ; 4CBZ ; 4XI7 ; 2VJ2 ; 4CC0 ; 5BO1 ; 4CC1
Drugbank	NA
KEGG	hsa:182

Type

Detail

Target ID

T16K98

Protein Name

Protein jagged-1

Uniprot ID

P78504

Protein Name Alias

Jagged1; hJ1; CD antigen CD339

Gene ID

182

Gene Symbol

JAG1

Gene Alias

JAGL1

TTD

Pfam

PF07657 ; PF00008 ; PF12661 ; PF07645 ; PF01414

2000737:negative regulation of stem cell differentiation

0045747:positive regulation of Notch signaling pathway

0005543:phospholipid binding

0001974:blood vessel remodeling

0060411:cardiac septum morphogenesis

0042127:regulation of cell population proliferation

0062043:positive regulation of cardiac epithelial to mesenchymal transition

0003180:aortic valve morphogenesis

0005576:extracellular region

0003215:cardiac right ventricle morphogenesis

0030216:keratinocyte differentiation

0016020:membrane

0002456:T cell mediated immunity

0045639:positive regulation of myeloid cell differentiation

0005912:adherens junction

0001525:angiogenesis

0007399:nervous system development

0005886:plasma membrane

0007219:Notch signaling pathway

0072015:glomerular visceral epithelial cell development

0003184:pulmonary valve morphogenesis

0072070:loop of Henle development

0005112:Notch binding

0045602:negative regulation of endothelial cell differentiation

0022408:negative regulation of cell-cell adhesion

0061444:endocardial cushion cell development

0005198:structural molecule activity

0061156:pulmonary artery morphogenesis

0030336:negative regulation of cell migration

0005509:calcium ion binding

0035909:aorta morphogenesis

0061309:cardiac neural crest cell development involved in outflow tract morphogenesis

0045665:negative regulation of neuron differentiation

0042491:inner ear auditory receptor cell differentiation

0002011:morphogenesis of an epithelial sheet

0045446:endothelial cell differentiation

0072017:distal tubule development

0045445:myoblast differentiation

0008083:growth factor activity

0097150:neuronal stem cell population maintenance

0061314:Notch signaling involved in heart development

0045669:positive regulation of osteoblast differentiation

0001953:negative regulation of cell-matrix adhesion

0030097:hemopoiesis

0005887:integral component of plasma membrane

0072006:nephron development

0001709:cell fate determination

0045944:positive regulation of transcription by RNA polymerase II

0045599:negative regulation of fat cell differentiation

0032495:response to muramyl dipeptide

0016324:apical plasma membrane

0061073:ciliary body morphogenesis

PDB

2KB9 ; 4CBZ ; 4XI7 ; 2VJ2 ; 4CC0 ; 5BO1 ; 4CC1

Drugbank

KEGG

hsa:182

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0077	Jiu	酒	Ethanol	Vinum
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 17)