HIT-result

Target Description

Type	Detail
Target ID	T45KYV
Protein Name	Stromal cell-derived factor 1
Uniprot ID	P48061
Protein Name Alias	SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF
Gene ID	6387
Gene Symbol	CXCL12
Gene Alias	SDF1; SDF1A; SDF1B
TTD	T04773: Clinical Trial target
Pfam	PF00048
GO	0070062:extracellular exosome 0005178:integrin binding 0070098:chemokine-mediated signaling pathway 1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 0033622:integrin activation 0050930:induction of positive chemotaxis 1990478:response to ultrasound 0045236:CXCR chemokine receptor binding 0045666:positive regulation of neuron differentiation 0001666:response to hypoxia 0001938:positive regulation of endothelial cell proliferation 0090026:positive regulation of monocyte chemotaxis 0045785:positive regulation of cell adhesion 0008344:adult locomotory behavior 0007186:G protein-coupled receptor signaling pathway 0042379:chemokine receptor binding 0005102:signaling receptor binding 0060326:cell chemotaxis 0001764:neuron migration 0009897:external side of plasma membrane 0005576:extracellular region 0050965:detection of temperature stimulus involved in sensory perception of pain 0008083:growth factor activity 0043434:response to peptide hormone 0033603:positive regulation of dopamine secretion 0031640:killing of cells of other organism 0008064:regulation of actin polymerization or depolymerization 0008009:chemokine activity 0009408:response to heat 0009314:response to radiation 0005737:cytoplasm 0008015:blood circulation 0038146:chemokine (C-X-C motif) ligand 12 signaling pathway 2000406:positive regulation of T cell migration 0022029:telencephalon cell migration 0030335:positive regulation of cell migration 1990869:cellular response to chemokine 0009615:response to virus 0005634:nucleus 0006955:immune response 0006874:cellular calcium ion homeostasis 0031100:animal organ regeneration 0006952:defense response 0007411:axon guidance 0006935:chemotaxis 0010818:T cell chemotaxis 0048842:positive regulation of axon extension involved in axon guidance 0090280:positive regulation of calcium ion import 0007155:cell adhesion 0062023:collagen-containing extracellular matrix 0007165:signal transduction 0016032:viral process 0061844:antimicrobial humoral immune response mediated by antimicrobial peptide 2000669:negative regulation of dendritic cell apoptotic process 0050966:detection of mechanical stimulus involved in sensory perception of pain 1903237:negative regulation of leukocyte tethering or rolling
PDB	2SDF ; 2KEC ; 2J7Z ; 2K04 ; 2K01 ; 2KED ; 2K03 ; 4LMQ ; 6SHR ; 2K05 ; 1SDF ; 2N55 ; 3GV3 ; 2KOL ; 1VMC ; 2KEE ; 2NWG ; 3HP3 ; 1A15 ; 4UAI ; 1QG7
Drugbank	DB06822 ; DB05934
KEGG	hsa:6387

Type

Detail

Target ID

T45KYV

Protein Name

Stromal cell-derived factor 1

Uniprot ID

P48061

Protein Name Alias

SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF

Gene ID

6387

Gene Symbol

CXCL12

Gene Alias

SDF1; SDF1A; SDF1B

TTD

T04773: Clinical Trial target

Pfam

PF00048

0070062:extracellular exosome

0005178:integrin binding

0070098:chemokine-mediated signaling pathway

1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

0033622:integrin activation

0050930:induction of positive chemotaxis

1990478:response to ultrasound

0045236:CXCR chemokine receptor binding

0045666:positive regulation of neuron differentiation

0001666:response to hypoxia

0001938:positive regulation of endothelial cell proliferation

0090026:positive regulation of monocyte chemotaxis

0045785:positive regulation of cell adhesion

0008344:adult locomotory behavior

0007186:G protein-coupled receptor signaling pathway

0042379:chemokine receptor binding

0005102:signaling receptor binding

0060326:cell chemotaxis

0001764:neuron migration

0009897:external side of plasma membrane

0005576:extracellular region

0050965:detection of temperature stimulus involved in sensory perception of pain

0008083:growth factor activity

0043434:response to peptide hormone

0033603:positive regulation of dopamine secretion

0031640:killing of cells of other organism

0008064:regulation of actin polymerization or depolymerization

0008009:chemokine activity

0009408:response to heat

0009314:response to radiation

0005737:cytoplasm

0008015:blood circulation

0038146:chemokine (C-X-C motif) ligand 12 signaling pathway

2000406:positive regulation of T cell migration

0022029:telencephalon cell migration

0030335:positive regulation of cell migration

1990869:cellular response to chemokine

0009615:response to virus

0005634:nucleus

0006955:immune response

0006874:cellular calcium ion homeostasis

0031100:animal organ regeneration

0006952:defense response

0007411:axon guidance

0006935:chemotaxis

0010818:T cell chemotaxis

0048842:positive regulation of axon extension involved in axon guidance

0090280:positive regulation of calcium ion import

0007155:cell adhesion

0062023:collagen-containing extracellular matrix

0007165:signal transduction

0016032:viral process

0061844:antimicrobial humoral immune response mediated by antimicrobial peptide

2000669:negative regulation of dendritic cell apoptotic process

0050966:detection of mechanical stimulus involved in sensory perception of pain

1903237:negative regulation of leukocyte tethering or rolling

PDB

2SDF ; 2KEC ; 2J7Z ; 2K04 ; 2K01 ; 2KED ; 2K03 ; 4LMQ ; 6SHR ; 2K05 ; 1SDF ; 2N55 ; 3GV3 ; 2KOL ; 1VMC ; 2KEE ; 2NWG ; 3HP3 ; 1A15 ; 4UAI ; 1QG7

Drugbank

DB06822 ; DB05934

KEGG

hsa:6387

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0077	Jiu	酒	Ethanol	Vinum
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 23)