HIT-result

Target Description

Type	Detail
Target ID	T91MLF
Protein Name	Alpha-1-antitrypsin
Uniprot ID	P01009
Protein Name Alias	Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Gene ID	5265
Gene Symbol	SERPINA1
Gene Alias	AAT; PI
TTD	T28265: Successful target
Pfam	PF00079
GO	0005788:endoplasmic reticulum lumen 0010951:negative regulation of endopeptidase activity 0044267:cellular protein metabolic process 0005576:extracellular region 0030134:COPII-coated ER to Golgi transport vesicle 0006888:endoplasmic reticulum to Golgi vesicle-mediated transport 0033116:endoplasmic reticulum-Golgi intermediate compartment membrane 0005783:endoplasmic reticulum 0031093:platelet alpha granule lumen 0043687:post-translational protein modification 0004867:serine-type endopeptidase inhibitor activity 0070062:extracellular exosome 0042802:identical protein binding 0043312:neutrophil degranulation 0043231:intracellular membrane-bounded organelle 0002020:protease binding 0002576:platelet degranulation 1904813:ficolin-1-rich granule lumen 0005794:Golgi apparatus 0006953:acute-phase response 0048208:COPII vesicle coating 0062023:collagen-containing extracellular matrix 0005615:extracellular space 0007596:blood coagulation
PDB	2QUG ; 6ROD ; 5IO1 ; 5NBV ; 2D26 ; 9API ; 3NE4 ; 3DRM ; 1EZX ; 1ATU ; 8API ; 3T1P ; 6HX4 ; 1HP7 ; 1OO8 ; 6I7U ; 7API ; 4PYW ; 6I4V ; 1PSI ; 1KCT ; 3NDD ; 1QMB ; 1D5S ; 6IAY ; 3DRU ; 3NDF ; 3CWM ; 1OPH ; 1QLP ; 5NBU ; 1IZ2 ; 3CWL
Drugbank	DB03345 ; DB01998 ; DB14487 ; DB01593 ; DB05481 ; DB05961 ; DB14533 ; DB14548 ; DB14007 ; DB09130
KEGG	hsa:5265

Type

Detail

Target ID

T91MLF

Protein Name

Alpha-1-antitrypsin

Uniprot ID

P01009

Protein Name Alias

Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1

Gene ID

5265

Gene Symbol

SERPINA1

Gene Alias

AAT; PI

TTD

T28265: Successful target

Pfam

PF00079

0005788:endoplasmic reticulum lumen

0010951:negative regulation of endopeptidase activity

0044267:cellular protein metabolic process

0005576:extracellular region

0030134:COPII-coated ER to Golgi transport vesicle

0006888:endoplasmic reticulum to Golgi vesicle-mediated transport

0033116:endoplasmic reticulum-Golgi intermediate compartment membrane

0005783:endoplasmic reticulum

0031093:platelet alpha granule lumen

0043687:post-translational protein modification

0004867:serine-type endopeptidase inhibitor activity

0070062:extracellular exosome

0042802:identical protein binding

0043312:neutrophil degranulation

0043231:intracellular membrane-bounded organelle

0002020:protease binding

0002576:platelet degranulation

1904813:ficolin-1-rich granule lumen

0005794:Golgi apparatus

0006953:acute-phase response

0048208:COPII vesicle coating

0062023:collagen-containing extracellular matrix

0005615:extracellular space

0007596:blood coagulation

PDB

2QUG ; 6ROD ; 5IO1 ; 5NBV ; 2D26 ; 9API ; 3NE4 ; 3DRM ; 1EZX ; 1ATU ; 8API ; 3T1P ; 6HX4 ; 1HP7 ; 1OO8 ; 6I7U ; 7API ; 4PYW ; 6I4V ; 1PSI ; 1KCT ; 3NDD ; 1QMB ; 1D5S ; 6IAY ; 3DRU ; 3NDF ; 3CWM ; 1OPH ; 1QLP ; 5NBU ; 1IZ2 ; 3CWL

Drugbank

DB03345 ; DB01998 ; DB14487 ; DB01593 ; DB05481 ; DB05961 ; DB14533 ; DB14548 ; DB14007 ; DB09130

KEGG

hsa:5265

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0077	Jiu	酒	Ethanol	Vinum
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 17)