HIT-result

Type	Detail
Target ID	T77YFO
Protein Name	Voltage-dependent L-type calcium channel subunit alpha-1C
Uniprot ID	Q13936
Protein Name Alias	Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2
Gene ID	775
Gene Symbol	CACNA1C
Gene Alias	CACH2; CACN2; CACNL1A1; CCHL1A1
TTD	T51115: Successful target
Pfam	PF00520 ; PF08763 ; PF16905 ; PF16885
GO	0098912:membrane depolarization during atrial cardiac muscle cell action potential 0086064:cell communication by electrical coupling involved in cardiac conduction 0045762:positive regulation of adenylate cyclase activity 0002520:immune system development 0046872:metal ion binding 0006816:calcium ion transport 0050796:regulation of insulin secretion 0014069:postsynaptic density 0098911:regulation of ventricular cardiac muscle cell action potential 0005891:voltage-gated calcium channel complex 0030425:dendrite 0070509:calcium ion import 0005245:voltage-gated calcium channel activity 0030018:Z disc 0060402:calcium ion transport into cytosol 0007204:positive regulation of cytosolic calcium ion concentration 0010881:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1990454:L-type voltage-gated calcium channel complex 0007507:heart development 0098839:postsynaptic density membrane 0043010:camera-type eye development 0016021:integral component of membrane 0035585:calcium-mediated signaling using extracellular calcium source 0061337:cardiac conduction 0061577:calcium ion transmembrane transport via high voltage-gated calcium channel 0086012:membrane depolarization during cardiac muscle cell action potential 0005886:plasma membrane 0008331:high voltage-gated calcium channel activity 0086007:voltage-gated calcium channel activity involved in cardiac muscle cell action potential 0043204:perikaryon 0035115:embryonic forelimb morphogenesis 0005887:integral component of plasma membrane 0086091:regulation of heart rate by cardiac conduction 0086056:voltage-gated calcium channel activity involved in AV node cell action potential 0086002:cardiac muscle cell action potential involved in contraction 0005516:calmodulin binding 0051393:alpha-actinin binding 0086045:membrane depolarization during AV node cell action potential 0005737:cytoplasm 0070588:calcium ion transmembrane transport 0016032:viral process
PDB	2BE6 ; 6U3B ; 6U39 ; 6DAF ; 6C0A ; 6DAD ; 6U3A ; 5V2Q ; 2F3Y ; 3G43 ; 1T0J ; 2LQC ; 2F3Z ; 5V2P ; 6DAE ; 3OXQ ; 6U3D
Drugbank	DB01388 ; DB01110 ; DB09227 ; DB00622 ; DB00343 ; DB12278 ; DB00661 ; DB00421 ; DB09236 ; DB00401 ; DB01373 ; DB00568 ; DB00252 ; DB00825 ; DB00243 ; DB11148 ; DB00308 ; DB04855 ; DB01118 ; DB00898 ; DB14481 ; DB13746 ; DB11633 ; DB00228 ; DB00153 ; DB00381 ; DB09235 ; DB09089 ; DB00653 ; DB09237 ; DB13961 ; DB00273 ; DB04920 ; DB01023 ; DB00270 ; DB06712 ; DB01054 ; DB01115 ; DB09232 ; DB00393 ; DB06751 ; DB09229 ; DB11348 ; DB09238 ; DB09231 ; DB11093
KEGG	hsa:775

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0077	Jiu	酒	Ethanol	Vinum
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens