Target Description

Type Detail
Target ID T52HO1
Protein Name HLA class I histocompatibility antigen, alpha chain G
Uniprot ID P17693
Protein Name Alias HLA G antigen;  MHC class I antigen G
Gene ID 3135
Gene Symbol HLA-G
Gene Alias HLA-6.0;  HLAG
TTD T95108: Clinical Trial target
Pfam PF00129 ; PF07654
GO
0042802:identical protein binding

0031527:filopodium membrane

0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

0045953:negative regulation of natural killer cell mediated cytotoxicity

0016525:negative regulation of angiogenesis

0050777:negative regulation of immune response

0045591:positive regulation of regulatory T cell differentiation

0042605:peptide antigen binding

0033106:cis-Golgi network membrane

2000353:positive regulation of endothelial cell apoptotic process

0060337:type I interferon signaling pathway

0002476:antigen processing and presentation of endogenous peptide antigen via MHC class Ib

0042612:MHC class I protein complex

0000139:Golgi membrane

0002474:antigen processing and presentation of peptide antigen via MHC class I

0001915:negative regulation of T cell mediated cytotoxicity

0042610:CD8 receptor binding

0002480:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

0032735:positive regulation of interleukin-12 production

0005615:extracellular space

0050776:regulation of immune response

0012507:ER to Golgi transport vesicle membrane

2001199:negative regulation of dendritic cell differentiation

0051898:negative regulation of protein kinase B signaling

0005886:plasma membrane

0002645:positive regulation of tolerance induction

0071556:integral component of lumenal side of endoplasmic reticulum membrane

0002666:positive regulation of T cell tolerance induction

0070207:protein homotrimerization

0016020:membrane

0002767:immune response-inhibiting cell surface receptor signaling pathway

0055038:recycling endosome membrane

0006968:cellular defense response

0031901:early endosome membrane

0005769:early endosome

0005102:signaling receptor binding

0060333:interferon-gamma-mediated signaling pathway

0042803:protein homodimerization activity

0042130:negative regulation of T cell proliferation

0060907:positive regulation of macrophage cytokine production

0042270:protection from natural killer cell mediated cytotoxicity

0030670:phagocytic vesicle membrane

0002729:positive regulation of natural killer cell cytokine production

0002451:peripheral B cell tolerance induction

2000774:positive regulation of cellular senescence

0009897:external side of plasma membrane

0070317:negative regulation of G0 to G1 transition

PDB 3BZE ; 3CDG ; 2D31 ; 3KYO ; 1YDP ; 3KYN ; 6K60 ; 3CII ; 2DYP ; 6AEE
Drugbank NA
KEGG hsa:3135

Related Compounds  (Total: 2)

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C0055
Name: Estradiol
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C1261
Name: Cpg


Related Herbs  (Total: 17)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0077 Jiu EthanolVinum