Target Description

Type Detail
Target ID T50HUJ
Protein Name Merlin
Uniprot ID P35240
Protein Name Alias Moesin-ezrin-radixin-like protein;  Neurofibromin-2;  Schwannomerlin;  Schwannomin
Gene ID 4771
Gene Symbol NF2
Gene Alias SCH
TTD T95742: Research target
Pfam PF00769 ; PF00373 ; PF09379 ; PF09380
GO
0005634:nucleus

0001953:negative regulation of cell-matrix adhesion

0031527:filopodium membrane

0003779:actin binding

0030864:cortical actin cytoskeleton

0072091:regulation of stem cell proliferation

0042981:regulation of apoptotic process

0042532:negative regulation of tyrosine phosphorylation of STAT protein

0005829:cytosol

0030336:negative regulation of cell migration

0043409:negative regulation of MAPK cascade

0051496:positive regulation of stress fiber assembly

0046426:negative regulation of receptor signaling pathway via JAK-STAT

0045216:cell-cell junction organization

0030036:actin cytoskeleton organization

0008285:negative regulation of cell population proliferation

0005737:cytoplasm

0043005:neuron projection

1900180:regulation of protein localization to nucleus

0070306:lens fiber cell differentiation

0005886:plasma membrane

0048471:perinuclear region of cytoplasm

0044297:cell body

0005912:adherens junction

0005856:cytoskeleton

0005730:nucleolus

0014013:regulation of gliogenesis

0014010:Schwann cell proliferation

0022408:negative regulation of cell-cell adhesion

0021766:hippocampus development

0016020:membrane

0007398:ectoderm development

0042475:odontogenesis of dentin-containing tooth

0032587:ruffle membrane

0032154:cleavage furrow

0005769:early endosome

2000177:regulation of neural precursor cell proliferation

0001707:mesoderm formation

0030027:lamellipodium

0045177:apical part of cell

0045597:positive regulation of cell differentiation

0035330:regulation of hippo signaling

0051726:regulation of cell cycle

0031647:regulation of protein stability

0006469:negative regulation of protein kinase activity

PDB 3U8Z ; 4ZRJ ; 4ZRI ; 6CDS ; 1H4R
Drugbank NA
KEGG hsa:4771

Related Compounds  (Total: 1)

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C0055
Name: Estradiol


Related Herbs  (Total: 17)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0077 Jiu EthanolVinum
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0847 Zi He Che紫河车 Human placentaHomo sapiens