HIT-result

Target Description

Type	Detail
Target ID	T32YAJ
Protein Name	G-protein coupled estrogen receptor 1
Uniprot ID	Q99527
Protein Name Alias	Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor; LYGPR; Membrane estrogen receptor; mER
Gene ID	2852
Gene Symbol	GPER1
Gene Alias	CEPR; CMKRL2; DRY12; GPER; GPR30
TTD	T65236: Successful target
Pfam	PF00001
GO	0030659:cytoplasmic vesicle membrane 0014069:postsynaptic density 0001934:positive regulation of protein phosphorylation 0043679:axon terminus 0007204:positive regulation of cytosolic calcium ion concentration 0010628:positive regulation of gene expression 0043401:steroid hormone mediated signaling pathway 0044327:dendritic spine head 0071375:cellular response to peptide hormone stimulus 0043410:positive regulation of MAPK cascade 0000139:Golgi membrane 0032591:dendritic spine membrane 0071389:cellular response to mineralocorticoid stimulus 0030264:nuclear fragmentation involved in apoptotic nuclear change 0045087:innate immune response 0005887:integral component of plasma membrane 0008284:positive regulation of cell population proliferation 0019228:neuronal action potential 0043198:dendritic shaft 0005737:cytoplasm 0005496:steroid binding 0048786:presynaptic active zone 0071157:negative regulation of cell cycle arrest 0005829:cytosol 0090200:positive regulation of release of cytochrome c from mitochondria 0030518:intracellular steroid hormone receptor signaling pathway 0051055:negative regulation of lipid biosynthetic process 0005654:nucleoplasm 0001956:positive regulation of neurotransmitter secretion 2001238:positive regulation of extrinsic apoptotic signaling pathway 0045944:positive regulation of transcription by RNA polymerase II 0005783:endoplasmic reticulum 0050769:positive regulation of neurogenesis 0008285:negative regulation of cell population proliferation 0005635:nuclear envelope 0007049:cell cycle 0043065:positive regulation of apoptotic process 0070374:positive regulation of ERK1 and ERK2 cascade 0005886:plasma membrane 0030424:axon 0030263:apoptotic chromosome condensation 0003707:steroid hormone receptor activity 0048471:perinuclear region of cytoplasm 0050728:negative regulation of inflammatory response 0030425:dendrite 0010948:negative regulation of cell cycle process 1904706:negative regulation of vascular associated smooth muscle cell proliferation 0006954:inflammatory response 0043231:intracellular membrane-bounded organelle 0030284:estrogen receptor activity 0010629:negative regulation of gene expression 0005802:trans-Golgi network 0055037:recycling endosome 0005730:nucleolus 0071333:cellular response to glucose stimulus 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0007186:G protein-coupled receptor signaling pathway 1903078:positive regulation of protein localization to plasma membrane 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0005634:nucleus 0070474:positive regulation of uterine smooth muscle contraction 0051480:regulation of cytosolic calcium ion concentration 0051898:negative regulation of protein kinase B signaling 0031966:mitochondrial membrane 0045095:keratin filament 0045742:positive regulation of epidermal growth factor receptor signaling pathway 0042311:vasodilation 0005789:endoplasmic reticulum membrane 0003682:chromatin binding 0071392:cellular response to estradiol stimulus 2000724:positive regulation of cardiac vascular smooth muscle cell differentiation 0045745:positive regulation of G protein-coupled receptor signaling pathway 0045599:negative regulation of fat cell differentiation 0002695:negative regulation of leukocyte activation 0030335:positive regulation of cell migration 0071356:cellular response to tumor necrosis factor 1990239:steroid hormone binding 0042734:presynaptic membrane 0051281:positive regulation of release of sequestered calcium ion into cytosol 2000353:positive regulation of endothelial cell apoptotic process 0004930:G protein-coupled receptor activity 0005794:Golgi apparatus 0005769:early endosome 0032962:positive regulation of inositol trisphosphate biosynthetic process 0032024:positive regulation of insulin secretion 0070373:negative regulation of ERK1 and ERK2 cascade
PDB	NA
Drugbank	DB13953 ; DB13956 ; DB13954 ; DB13952 ; DB01645 ; DB05939 ; DB00783 ; DB13955
KEGG	hsa:2852

Type

Detail

Target ID

T32YAJ

Protein Name

G-protein coupled estrogen receptor 1

Uniprot ID

Q99527

Protein Name Alias

Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor; LYGPR; Membrane estrogen receptor; mER

Gene ID

2852

Gene Symbol

GPER1

Gene Alias

CEPR; CMKRL2; DRY12; GPER; GPR30

TTD

T65236: Successful target

Pfam

PF00001

0030659:cytoplasmic vesicle membrane

0014069:postsynaptic density

0001934:positive regulation of protein phosphorylation

0043679:axon terminus

0007204:positive regulation of cytosolic calcium ion concentration

0010628:positive regulation of gene expression

0043401:steroid hormone mediated signaling pathway

0044327:dendritic spine head

0071375:cellular response to peptide hormone stimulus

0043410:positive regulation of MAPK cascade

0000139:Golgi membrane

0032591:dendritic spine membrane

0071389:cellular response to mineralocorticoid stimulus

0030264:nuclear fragmentation involved in apoptotic nuclear change

0045087:innate immune response

0005887:integral component of plasma membrane

0008284:positive regulation of cell population proliferation

0019228:neuronal action potential

0043198:dendritic shaft

0005737:cytoplasm

0005496:steroid binding

0048786:presynaptic active zone

0071157:negative regulation of cell cycle arrest

0005829:cytosol

0090200:positive regulation of release of cytochrome c from mitochondria

0030518:intracellular steroid hormone receptor signaling pathway

0051055:negative regulation of lipid biosynthetic process

0005654:nucleoplasm

0001956:positive regulation of neurotransmitter secretion

2001238:positive regulation of extrinsic apoptotic signaling pathway

0045944:positive regulation of transcription by RNA polymerase II

0005783:endoplasmic reticulum

0050769:positive regulation of neurogenesis

0008285:negative regulation of cell population proliferation

0005635:nuclear envelope

0007049:cell cycle

0043065:positive regulation of apoptotic process

0070374:positive regulation of ERK1 and ERK2 cascade

0005886:plasma membrane

0030424:axon

0030263:apoptotic chromosome condensation

0003707:steroid hormone receptor activity

0048471:perinuclear region of cytoplasm

0050728:negative regulation of inflammatory response

0030425:dendrite

0010948:negative regulation of cell cycle process

1904706:negative regulation of vascular associated smooth muscle cell proliferation

0006954:inflammatory response

0043231:intracellular membrane-bounded organelle

0030284:estrogen receptor activity

0010629:negative regulation of gene expression

0005802:trans-Golgi network

0055037:recycling endosome

0005730:nucleolus

0071333:cellular response to glucose stimulus

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0007186:G protein-coupled receptor signaling pathway

1903078:positive regulation of protein localization to plasma membrane

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0005634:nucleus

0070474:positive regulation of uterine smooth muscle contraction

0051480:regulation of cytosolic calcium ion concentration

0051898:negative regulation of protein kinase B signaling

0031966:mitochondrial membrane

0045095:keratin filament

0045742:positive regulation of epidermal growth factor receptor signaling pathway

0042311:vasodilation

0005789:endoplasmic reticulum membrane

0003682:chromatin binding

0071392:cellular response to estradiol stimulus

2000724:positive regulation of cardiac vascular smooth muscle cell differentiation

0045745:positive regulation of G protein-coupled receptor signaling pathway

0045599:negative regulation of fat cell differentiation

0002695:negative regulation of leukocyte activation

0030335:positive regulation of cell migration

0071356:cellular response to tumor necrosis factor

1990239:steroid hormone binding

0042734:presynaptic membrane

0051281:positive regulation of release of sequestered calcium ion into cytosol

2000353:positive regulation of endothelial cell apoptotic process

0004930:G protein-coupled receptor activity

0005794:Golgi apparatus

0005769:early endosome

0032962:positive regulation of inositol trisphosphate biosynthetic process

0032024:positive regulation of insulin secretion

0070373:negative regulation of ERK1 and ERK2 cascade

PDB

Drugbank

DB13953 ; DB13956 ; DB13954 ; DB13952 ; DB01645 ; DB05939 ; DB00783 ; DB13955

KEGG

hsa:2852

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0075	Jing Mi	粳米	Rice	Oryza sativa
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0077	Jiu	酒	Ethanol	Vinum
H0416	Shan Shen	山参	NA	Panax ginseng

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 27)