HIT-result

Target Description

Type	Detail
Target ID	T93LMN
Protein Name	Microtubule-associated protein tau
Uniprot ID	P10636
Protein Name Alias	Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
Gene ID	4137
Gene Symbol	MAPT
Gene Alias	MAPTL; MTBT1; TAU
TTD	T45593: Clinical Trial target
Pfam	PF00418
GO	0033044:regulation of chromosome organization 0010629:negative regulation of gene expression 0051258:protein polymerization 0071813:lipoprotein particle binding 0098930:axonal transport 0005576:extracellular region 0051260:protein homooligomerization 0030673:axolemma 0010288:response to lead ion 0019896:axonal transport of mitochondrion 0044304:main axon 0006475:internal protein amino acid acetylation 1990000:amyloid fibril formation 1904115:axon cytoplasm 0007613:memory 1902988:neurofibrillary tangle assembly 0070507:regulation of microtubule cytoskeleton organization 0031110:regulation of microtubule polymerization or depolymerization 0061564:axon development 0003690:double-stranded DNA binding 0031122:cytoplasmic microtubule organization 0051087:chaperone binding 1902474:positive regulation of protein localization to synapse 0030425:dendrite 0097418:neurofibrillary tangle 0043025:neuronal cell body 0001774:microglial cell activation 0050848:regulation of calcium-mediated signaling 0003680:minor groove of adenine-thymine-rich DNA binding 0030426:growth cone 0034063:stress granule assembly 0042802:identical protein binding 0097386:glial cell projection 1903748:negative regulation of establishment of protein localization to mitochondrion 0019899:enzyme binding 0035091:phosphatidylinositol binding 0097435:supramolecular fiber organization 0003723:RNA binding 0048167:regulation of synaptic plasticity 0099609:microtubule lateral binding 0034399:nuclear periphery 0090140:regulation of mitochondrial fission 0030424:axon 0048312:intracellular distribution of mitochondria 0034614:cellular response to reactive oxygen species 0099077:histone-dependent DNA binding 0048143:astrocyte activation 1905689:positive regulation of diacylglycerol kinase activity 1900034:regulation of cellular response to heat 0044297:cell body 0051721:protein phosphatase 2A binding 0033673:negative regulation of kinase activity 0072386:plus-end-directed organelle transport along microtubule 0043197:dendritic spine 2001020:regulation of response to DNA damage stimulus 0050808:synapse organization 1902936:phosphatidylinositol bisphosphate binding 0000226:microtubule cytoskeleton organization 1904428:negative regulation of tubulin deacetylation 0016072:rRNA metabolic process 0005874:microtubule 0034605:cellular response to heat 1990090:cellular response to nerve growth factor stimulus 0005886:plasma membrane 0043565:sequence-specific DNA binding 0007416:synapse assembly 0003677:DNA binding 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0015630:microtubule cytoskeleton 0017124:SH3 domain binding 0045298:tubulin complex 0005739:mitochondrion 0005634:nucleus 0019901:protein kinase binding 0051879:Hsp90 protein binding 0003779:actin binding 0008017:microtubule binding 0031116:positive regulation of microtubule polymerization 0010506:regulation of autophagy 0021954:central nervous system neuron development 1990416:cellular response to brain-derived neurotrophic factor stimulus 0046785:microtubule polymerization 0010917:negative regulation of mitochondrial membrane potential 0005829:cytosol 0048699:generation of neurons 0031175:neuron projection development 1903829:positive regulation of cellular protein localization 0036464:cytoplasmic ribonucleoprotein granule 0030674:protein-macromolecule adaptor activity 0034185:apolipoprotein binding 0007267:cell-cell signaling 0003697:single-stranded DNA binding 0034452:dynactin binding 0043005:neuron projection 1901216:positive regulation of neuron death 0007611:learning or memory 0005737:cytoplasm 0045773:positive regulation of axon extension 0090258:negative regulation of mitochondrial fission 0016607:nuclear speck 0036477:somatodendritic compartment 0032930:positive regulation of superoxide anion generation 0031113:regulation of microtubule polymerization 0045121:membrane raft 1900452:regulation of long-term synaptic depression
PDB	4Y32 ; 6GK7 ; 6QJH ; 5DMG ; 6VHA ; 5ZV3 ; 6FBW ; 5K7N ; 6DCA ; 6BB4 ; 6TJX ; 5N5B ; 6DC8 ; 5V5B ; 4E0O ; 5N5A ; 4GLR ; 6ODG ; 4NP8 ; 4TQE ; 6QJP ; 5O3T ; 2ON9 ; 3OVL ; 5MP3 ; 6GX5 ; 6LRA ; 5O3L ; 6N4P ; 6VI3 ; 6GK8 ; 4FL5 ; 6DC9 ; 6HRE ; 6NWP ; 6NWQ ; 5ZIA ; 5HF3 ; 6FI5 ; 5E2W ; 4E0M ; 5E2V ; 6VHL ; 1I8H ; 4Y5I ; 6NK4 ; 5MO3 ; 6QJM ; 6QJQ ; 6XLI ; 6TJO ; 6HRF ; 6H06 ; 5MP1 ; 6VH7 ; 4Y3B ; 4E0N ; 6CVJ ; 6PXR ; 5O3O ; 5NVB ; 6CVN ; 5V5C ; 5MP5 ; 2MZ7
Drugbank	DB00448 ; DB01248 ; DB01229 ; DB00637 ; DB14914
KEGG	hsa:4137

Type

Detail

Target ID

T93LMN

Protein Name

Microtubule-associated protein tau

Uniprot ID

P10636

Protein Name Alias

Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Gene ID

4137

Gene Symbol

MAPT

Gene Alias

MAPTL; MTBT1; TAU

TTD

T45593: Clinical Trial target

Pfam

PF00418

0033044:regulation of chromosome organization

0010629:negative regulation of gene expression

0051258:protein polymerization

0071813:lipoprotein particle binding

0098930:axonal transport

0005576:extracellular region

0051260:protein homooligomerization

0030673:axolemma

0010288:response to lead ion

0019896:axonal transport of mitochondrion

0044304:main axon

0006475:internal protein amino acid acetylation

1990000:amyloid fibril formation

1904115:axon cytoplasm

0007613:memory

1902988:neurofibrillary tangle assembly

0070507:regulation of microtubule cytoskeleton organization

0031110:regulation of microtubule polymerization or depolymerization

0061564:axon development

0003690:double-stranded DNA binding

0031122:cytoplasmic microtubule organization

0051087:chaperone binding

1902474:positive regulation of protein localization to synapse

0030425:dendrite

0097418:neurofibrillary tangle

0043025:neuronal cell body

0001774:microglial cell activation

0050848:regulation of calcium-mediated signaling

0003680:minor groove of adenine-thymine-rich DNA binding

0030426:growth cone

0034063:stress granule assembly

0042802:identical protein binding

0097386:glial cell projection

1903748:negative regulation of establishment of protein localization to mitochondrion

0019899:enzyme binding

0035091:phosphatidylinositol binding

0097435:supramolecular fiber organization

0003723:RNA binding

0048167:regulation of synaptic plasticity

0099609:microtubule lateral binding

0034399:nuclear periphery

0090140:regulation of mitochondrial fission

0030424:axon

0048312:intracellular distribution of mitochondria

0034614:cellular response to reactive oxygen species

0099077:histone-dependent DNA binding

0048143:astrocyte activation

1905689:positive regulation of diacylglycerol kinase activity

1900034:regulation of cellular response to heat

0044297:cell body

0051721:protein phosphatase 2A binding

0033673:negative regulation of kinase activity

0072386:plus-end-directed organelle transport along microtubule

0043197:dendritic spine

2001020:regulation of response to DNA damage stimulus

0050808:synapse organization

1902936:phosphatidylinositol bisphosphate binding

0000226:microtubule cytoskeleton organization

1904428:negative regulation of tubulin deacetylation

0016072:rRNA metabolic process

0005874:microtubule

0034605:cellular response to heat

1990090:cellular response to nerve growth factor stimulus

0005886:plasma membrane

0043565:sequence-specific DNA binding

0007416:synapse assembly

0003677:DNA binding

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0015630:microtubule cytoskeleton

0017124:SH3 domain binding

0045298:tubulin complex

0005739:mitochondrion

0005634:nucleus

0019901:protein kinase binding

0051879:Hsp90 protein binding

0003779:actin binding

0008017:microtubule binding

0031116:positive regulation of microtubule polymerization

0010506:regulation of autophagy

0021954:central nervous system neuron development

1990416:cellular response to brain-derived neurotrophic factor stimulus

0046785:microtubule polymerization

0010917:negative regulation of mitochondrial membrane potential

0005829:cytosol

0048699:generation of neurons

0031175:neuron projection development

1903829:positive regulation of cellular protein localization

0036464:cytoplasmic ribonucleoprotein granule

0030674:protein-macromolecule adaptor activity

0034185:apolipoprotein binding

0007267:cell-cell signaling

0003697:single-stranded DNA binding

0034452:dynactin binding

0043005:neuron projection

1901216:positive regulation of neuron death

0007611:learning or memory

0005737:cytoplasm

0045773:positive regulation of axon extension

0090258:negative regulation of mitochondrial fission

0016607:nuclear speck

0036477:somatodendritic compartment

0032930:positive regulation of superoxide anion generation

0031113:regulation of microtubule polymerization

0045121:membrane raft

1900452:regulation of long-term synaptic depression

PDB

4Y32 ; 6GK7 ; 6QJH ; 5DMG ; 6VHA ; 5ZV3 ; 6FBW ; 5K7N ; 6DCA ; 6BB4 ; 6TJX ; 5N5B ; 6DC8 ; 5V5B ; 4E0O ; 5N5A ; 4GLR ; 6ODG ; 4NP8 ; 4TQE ; 6QJP ; 5O3T ; 2ON9 ; 3OVL ; 5MP3 ; 6GX5 ; 6LRA ; 5O3L ; 6N4P ; 6VI3 ; 6GK8 ; 4FL5 ; 6DC9 ; 6HRE ; 6NWP ; 6NWQ ; 5ZIA ; 5HF3 ; 6FI5 ; 5E2W ; 4E0M ; 5E2V ; 6VHL ; 1I8H ; 4Y5I ; 6NK4 ; 5MO3 ; 6QJM ; 6QJQ ; 6XLI ; 6TJO ; 6HRF ; 6H06 ; 5MP1 ; 6VH7 ; 4Y3B ; 4E0N ; 6CVJ ; 6PXR ; 5O3O ; 5NVB ; 6CVN ; 5V5C ; 5MP5 ; 2MZ7

Drugbank

DB00448 ; DB01248 ; DB01229 ; DB00637 ; DB14914

KEGG

hsa:4137

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Name: Progesterone

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Name: Ginsenoside Rg1

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Name: ginsenoside rb1

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0378	San Qi	三七	Sanchi	Panax notoginseng
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 11)