Target Description

Type Detail
Target ID T53ZQH
Protein Name Growth/differentiation factor 8
Uniprot ID O14793
Protein Name Alias GDF-8;  Myostatin
Gene ID 2660
Gene Symbol MSTN
Gene Alias GDF8
TTD T87749: Clinical Trial target
Pfam PF00019 ; PF00688
GO
0033574:response to testosterone

0014732:skeletal muscle atrophy

0071549:cellular response to dexamethasone stimulus

0051898:negative regulation of protein kinase B signaling

1902723:negative regulation of skeletal muscle satellite cell proliferation

0048632:negative regulation of skeletal muscle tissue growth

0008083:growth factor activity

0042803:protein homodimerization activity

0043627:response to estrogen

0060395:SMAD protein signal transduction

0042802:identical protein binding

0005615:extracellular space

0022602:ovulation cycle process

0005125:cytokine activity

0010759:positive regulation of macrophage chemotaxis

0045893:positive regulation of transcription, DNA-templated

0014741:negative regulation of muscle hypertrophy

0010592:positive regulation of lamellipodium assembly

0046627:negative regulation of insulin receptor signaling pathway

0045471:response to ethanol

2000818:negative regulation of myoblast proliferation

0005102:signaling receptor binding

0045662:negative regulation of myoblast differentiation

0007517:muscle organ development

0014839:myoblast migration involved in skeletal muscle regeneration

0033673:negative regulation of kinase activity

0007179:transforming growth factor beta receptor signaling pathway

0046716:muscle cell cellular homeostasis

0014850:response to muscle activity

0009408:response to heat

1902725:negative regulation of satellite cell differentiation

0005737:cytoplasm

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0008201:heparin binding

0051602:response to electrical stimulus

0009629:response to gravity

PDB 5F3B ; 5NTU ; 5NXS ; 6UMX ; 5F3H
Drugbank DB05915
KEGG hsa:2660

Related Compounds  (Total: 1)

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C0325
Name: Progesterone


Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica