Target Description

Type Detail
Target ID T68OE2
Protein Name Pro-neuregulin-1, membrane-bound isoform
Uniprot ID Q02297
Protein Name Alias Pro-NRG1
Gene ID 3084
Gene Symbol NRG1
Gene Alias GGF;  HGL;  HRGA;  NDF;  SMDF
TTD T65198: Clinical Trial target
Pfam PF00008 ; PF02158 ; PF07679
GO
2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0008283:cell population proliferation

0005178:integrin binding

0043125:ErbB-3 class receptor binding

0007399:nervous system development

1900086:positive regulation of peptidyl-tyrosine autophosphorylation

0035556:intracellular signal transduction

0060379:cardiac muscle cell myoblast differentiation

0000165:MAPK cascade

0005615:extracellular space

0016021:integral component of membrane

0045499:chemorepellent activity

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0014032:neural crest cell development

0016020:membrane

0099061:integral component of postsynaptic density membrane

0045785:positive regulation of cell adhesion

0051048:negative regulation of secretion

0005102:signaling receptor binding

0038128:ERBB2 signaling pathway

0099059:integral component of presynaptic active zone membrane

0003712:transcription coregulator activity

0005576:extracellular region

0030154:cell differentiation

0008083:growth factor activity

0010667:negative regulation of cardiac muscle cell apoptotic process

0030307:positive regulation of cell growth

0030296:protein tyrosine kinase activator activity

0005886:plasma membrane

0030297:transmembrane receptor protein tyrosine kinase activator activity

0038129:ERBB3 signaling pathway

0005654:nucleoplasm

0098978:glutamatergic synapse

2000145:regulation of cell motility

0055012:ventricular cardiac muscle cell differentiation

0003222:ventricular trabecula myocardium morphogenesis

0060045:positive regulation of cardiac muscle cell proliferation

0005125:cytokine activity

0099560:synaptic membrane adhesion

0007154:cell communication

0038130:ERBB4 signaling pathway

0030971:receptor tyrosine kinase binding

0099149:regulation of postsynaptic neurotransmitter receptor internalization

0031334:positive regulation of protein-containing complex assembly

0008284:positive regulation of cell population proliferation

0051155:positive regulation of striated muscle cell differentiation

0043624:cellular protein complex disassembly

0038127:ERBB signaling pathway

0042060:wound healing

0032148:activation of protein kinase B activity

0045892:negative regulation of transcription, DNA-templated

0007171:activation of transmembrane receptor protein tyrosine kinase activity

0048513:animal organ development

0055007:cardiac muscle cell differentiation

0000187:activation of MAPK activity

0030879:mammary gland development

0060956:endocardial cell differentiation

0051897:positive regulation of protein kinase B signaling

0016324:apical plasma membrane

PDB 1HAE ; 1HRE ; 1HAF ; 3U7U ; 1HRF
Drugbank NA
KEGG hsa:3084

Related Compounds  (Total: 3)

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C0048
Name: Epinephrine
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C0325
Name: Progesterone
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C1113
Name: heparin


Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica